SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gkd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2gkd CALC
(Micromonospora
echinospora) 		4 / 7 ILE A 140
ARG A  82
ILE A  79
PHE A  23
 None
 0.91A 2q6hA-2gkdA:
undetectable		 2q6hA-2gkdA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_D_ASDD1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2gkd CALC
(Micromonospora
echinospora) 		4 / 7 ILE A 140
GLY A 136
LEU A  83
PHE A  65
 None
 0.89A 2vctD-2gkdA:
undetectable		 2vctD-2gkdA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4APJ_A_ACTA1635_0
(ANGIOTENSIN-CONVERTI
NG ENZYME
BRADYKININ-POTENTIAT
ING PEPTIDE B)		 2gkd CALC
(Micromonospora
echinospora) 		4 / 6 HIS A 117
HIS A 115
GLU A  96
SER A  94
 None
 1.36A 4apjA-2gkdA:
undetectable
4apjP-2gkdA:
undetectable		 4apjA-2gkdA:
15.63
4apjP-2gkdA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_C_NCTC501_1
(CYTOCHROME P450 2A6)		 2gkd CALC
(Micromonospora
echinospora) 		4 / 5 PHE A  27
PHE A  65
ILE A 140
GLY A 136
 None
 1.02A 4ejjC-2gkdA:
undetectable		 4ejjC-2gkdA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2gkd CALC
(Micromonospora
echinospora) 		3 / 3 GLY A  60
GLU A  62
THR A  38
 None
 0.53A 4kouA-2gkdA:
undetectable		 4kouA-2gkdA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XNX_A_41XA707_1
(TRANSPORTER)		 2gkd CALC
(Micromonospora
echinospora) 		5 / 11 VAL A  46
ASP A  47
TYR A  54
GLY A  80
GLY A  51
 None
 1.26A 4xnxA-2gkdA:
undetectable		 4xnxA-2gkdA:
12.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JGL_B_SAMB301_1
(UBIE/COQ5 FAMILY
METHYLTRANSFERASE,
PUTATIVE)		 2gkd CALC
(Micromonospora
echinospora) 		3 / 3 ASP A  90
ASN A 131
PHE A 118
 None
 0.93A 5jglB-2gkdA:
undetectable		 5jglB-2gkdA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_1
(RIFAMPIN
MONOOXYGENASE)		 2gkd CALC
(Micromonospora
echinospora) 		5 / 12 HIS A  63
LEU A  77
VAL A  71
PHE A  20
GLY A  45
 None
 1.40A 6brdA-2gkdA:
undetectable		 6brdA-2gkdA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2gkd CALC
(Micromonospora
echinospora) 		4 / 4 ASP A  47
ILE A  56
PRO A  43
LEU A  44
 None
 1.32A 6mkeB-2gkdA:
undetectable		 6mkeB-2gkdA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2gkd CALC
(Micromonospora
echinospora) 		4 / 4 ASP A  47
ILE A  56
PRO A  43
LEU A  44
 None
 1.34A 6mkeA-2gkdA:
undetectable		 6mkeA-2gkdA:
19.40