SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gki'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XL6_B_SPMB3001_1
(INWARD RECTIFIER
POTASSIUM CHANNEL)		 2gki NUCLEASE
(Mus
musculus) 		4 / 5 ALA A 122
TYR A 123
ALA A 128
TYR A 127
 None
 0.67A 1xl6A-2gkiA:
2.8
1xl6B-2gkiA:
2.7		 1xl6A-2gkiA:
19.88
1xl6B-2gkiA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2L8M_A_CAMA415_0
(CAMPHOR
5-MONOOXYGENASE)		 2gki NUCLEASE
(Mus
musculus) 		5 / 9 THR A 266
LEU A 169
VAL A 171
ILE A 239
VAL A 242
 None
 1.46A 2l8mA-2gkiA:
undetectable		 2l8mA-2gkiA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 2gki NUCLEASE
(Mus
musculus) 		4 / 4 ALA A 122
TYR A 123
ALA A 128
TYR A 127
 None
 0.70A 2wlkA-2gkiA:
2.9
2wlkB-2gkiA:
2.5		 2wlkA-2gkiA:
19.88
2wlkB-2gkiA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_A_1GNA607_1
(PHIAB6 TAILSPIKE)		 2gki NUCLEASE
(Mus
musculus) 		3 / 3 THR A  50
SER A  53
TYR A  54
 None
 0.82A 5jsdA-2gkiA:
2.4		 5jsdA-2gkiA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_B_1GNB618_1
(PHIAB6 TAILSPIKE)		 2gki NUCLEASE
(Mus
musculus) 		3 / 3 THR A  50
SER A  53
TYR A  54
 None
 0.82A 5jsdB-2gkiA:
undetectable		 5jsdB-2gkiA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSD_C_1GNC608_1
(PHIAB6 TAILSPIKE)		 2gki NUCLEASE
(Mus
musculus) 		3 / 3 THR A  50
SER A  53
TYR A  54
 None
 0.82A 5jsdC-2gkiA:
undetectable		 5jsdC-2gkiA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_A_1GNA608_1
(PHIAB6 TAILSPIKE)		 2gki NUCLEASE
(Mus
musculus) 		3 / 3 THR A  50
SER A  53
TYR A  54
 None
 0.84A 5jseA-2gkiA:
2.4		 5jseA-2gkiA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_B_1GNB611_1
(PHIAB6 TAILSPIKE)		 2gki NUCLEASE
(Mus
musculus) 		3 / 3 THR A  50
SER A  53
TYR A  54
 None
 0.83A 5jseB-2gkiA:
undetectable		 5jseB-2gkiA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JSE_C_1GNC611_1
(PHIAB6 TAILSPIKE)		 2gki NUCLEASE
(Mus
musculus) 		3 / 3 THR A  50
SER A  53
TYR A  54
 None
 0.83A 5jseC-2gkiA:
undetectable		 5jseC-2gkiA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BEC_C_RBTC601_1
(SCAFFOLD PROTEIN D13)		 2gki NUCLEASE
(Mus
musculus) 		5 / 12 VAL A 171
VAL A 222
GLN A 206
ILE A 212
PHE A 226
 None
 1.27A 6becA-2gkiA:
1.9
6becB-2gkiA:
2.7
6becC-2gkiA:
undetectable		 6becA-2gkiA:
17.19
6becB-2gkiA:
17.19
6becC-2gkiA:
17.19