SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gko'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C9S_V_TRPV81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
5 / 10 GLY A  77
THR A  73
GLY A 240
HIS A  41
ALA A 243
None
1.17A 1c9sL-2gkoA:
undetectable
1c9sV-2gkoA:
undetectable
1c9sL-2gkoA:
12.38
1c9sV-2gkoA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 166
ALA A 165
VAL A 233
ILE A 245
HIS A  74
None
PMS  A 601 ( 3.8A)
None
PMS  A 601 (-4.5A)
None
1.02A 1fm6U-2gkoA:
undetectable
1fm6U-2gkoA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JR1_B_MOAB1333_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 8 ASN A  47
GLY A  77
THR A 236
GLY A  88
None
0.68A 1jr1B-2gkoA:
undetectable
1jr1B-2gkoA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PBC_A_BHAA396_0
(P-HYDROXYBENZOATE
HYDROXYLASE)
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
5 / 10 GLY A  72
VAL A  37
LEU A  44
LEU A  80
ALA A 100
None
0.88A 1pbcA-2gkoA:
undetectable
1pbcA-2gkoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RL8_A_RITA9001_1
(PROTEASE RETROPEPSIN)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
6 / 12 GLY A 140
ASP A  34
VAL A 103
ILE A 162
ALA A 116
ILE A 115
None
1.40A 1rl8A-2gkoA:
undetectable
1rl8A-2gkoA:
15.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_U_TRPU81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
5 / 10 GLY A 240
HIS A  41
ALA A 243
GLY A  77
THR A  73
None
1.20A 1utdU-2gkoA:
undetectable
1utdV-2gkoA:
undetectable
1utdU-2gkoA:
12.38
1utdV-2gkoA:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 5 LEU A 288
ASP A 286
GLY A 215
ALA A 293
None
CA  A 612 (-3.1A)
None
None
0.97A 2aohA-2gkoA:
undetectable
2aohA-2gkoA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AXN_A_EDTA737_0
(6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
PHOSPHATASE 3
(6PF-2-K/FRU-
2,6-P2ASE
BRAIN/PLACENTA-TYPE
ISOZYME) (IPFK-2)
[INCLUDES: 6-
PHOSPHOFRUCTO-2-KINA
SE (EC 2.7.1.105)
FRUCTOSE-2,6-BISPHO
SPHATASE (EC
3.1.3.46)])
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
5 / 12 PRO A   7
THR A  22
GLY A  83
ALA A  81
TYR A 234
None
1.43A 2axnA-2gkoA:
undetectable
2axnA-2gkoA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_A_SAMA302_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
3 / 3 THR A  61
ASP A 106
SER A 109
None
0.83A 2nxeA-2gkoA:
undetectable
2nxeA-2gkoA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NXE_B_SAMB303_1
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
3 / 3 THR A  61
ASP A 106
SER A 109
None
0.80A 2nxeB-2gkoA:
undetectable
2nxeB-2gkoA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_A_ASDA1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 7 PHE A 205
ALA A 251
LEU A 191
ALA A 203
None
0.85A 2vcvA-2gkoA:
undetectable
2vcvA-2gkoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_F_ASDF1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 8 PHE A 205
ALA A 251
LEU A 191
ALA A 203
None
0.88A 2vcvF-2gkoA:
undetectable
2vcvF-2gkoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_G_ASDG1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 7 PHE A 205
ALA A 251
LEU A 191
ALA A 203
None
0.88A 2vcvG-2gkoA:
undetectable
2vcvG-2gkoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCV_L_ASDL1224_1
(GLUTATHIONE
S-TRANSFERASE A3)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 7 PHE A 205
ALA A 251
LEU A 191
ALA A 203
None
0.85A 2vcvL-2gkoA:
undetectable
2vcvL-2gkoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YVL_D_SAMD603_0
(HYPOTHETICAL PROTEIN)
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
5 / 12 GLY A 230
ALA A 232
ALA A 165
VAL A 188
VAL A  75
None
None
PMS  A 601 ( 3.8A)
None
None
1.16A 2yvlD-2gkoA:
2.2
2yvlD-2gkoA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA601_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 7 GLY A 209
ALA A 189
ALA A 187
VAL A 202
None
None
NA  A 614 ( 4.1A)
None
0.81A 3a2qA-2gkoA:
undetectable
3a2qA-2gkoA:
25.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ADS_A_IMNA2_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 6 ILE A 163
ILE A  10
TYR A  14
LEU A 161
None
0.98A 3adsA-2gkoA:
undetectable
3adsA-2gkoA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 8 SER A 206
VAL A 202
LEU A 191
ALA A 231
None
0.99A 3ax7A-2gkoA:
undetectable
3ax7A-2gkoA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_B_SAMB301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
5 / 12 GLY A  77
SER A 235
THR A 236
ILE A  30
ASP A  43
None
1.28A 3iv6B-2gkoA:
2.5
3iv6B-2gkoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 165
VAL A  75
GLY A  77
ALA A  76
LEU A  98
PMS  A 601 ( 3.8A)
None
None
None
None
0.96A 3ln1A-2gkoA:
undetectable
3ln1A-2gkoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 165
VAL A  75
GLY A  77
ALA A  76
LEU A  98
PMS  A 601 ( 3.8A)
None
None
None
None
0.95A 3ln1B-2gkoA:
undetectable
3ln1B-2gkoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 165
VAL A  75
GLY A  77
ALA A  76
LEU A  98
PMS  A 601 ( 3.8A)
None
None
None
None
0.96A 3ln1C-2gkoA:
undetectable
3ln1C-2gkoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 165
VAL A  75
GLY A  77
ALA A  76
LEU A  98
PMS  A 601 ( 3.8A)
None
None
None
None
0.94A 3ln1D-2gkoA:
0.7
3ln1D-2gkoA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S8P_B_SAMB500_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
3 / 3 HIS A  71
SER A 252
ASN A 168
PMS  A 601 (-3.1A)
None
PMS  A 601 (-3.0A)
0.87A 3s8pB-2gkoA:
undetectable
3s8pB-2gkoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DRJ_A_RAPA201_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4
SERINE/THREONINE-PRO
TEIN KINASE MTOR)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 8 LEU A 139
SER A 249
THR A  73
ASP A  67
None
PMS  A 601 (-1.7A)
None
None
1.08A 4drjB-2gkoA:
undetectable
4drjB-2gkoA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_A_MOAA502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 8 SER A 175
SER A 207
THR A 248
GLY A 140
None
None
PMS  A 601 (-4.7A)
None
0.90A 4fo4A-2gkoA:
undetectable
4fo4A-2gkoA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 8 ASN A  47
GLY A  77
THR A 236
GLY A  88
None
0.69A 4fo4B-2gkoA:
undetectable
4fo4B-2gkoA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FO4_B_MOAB502_1
(INOSINE
5'-MONOPHOSPHATE
DEHYDROGENASE)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 8 SER A 175
SER A 207
THR A 248
GLY A 140
None
None
PMS  A 601 (-4.7A)
None
0.84A 4fo4B-2gkoA:
undetectable
4fo4B-2gkoA:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 8 ALA A  96
GLY A  91
PRO A 253
ILE A  30
None
0.75A 4ll3A-2gkoA:
undetectable
4ll3A-2gkoA:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A  79
ILE A 262
GLY A  25
ALA A  96
VAL A 134
None
0.95A 4nkvA-2gkoA:
undetectable
4nkvA-2gkoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_B_AERB601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A  79
ILE A 262
GLY A  25
ALA A  96
VAL A 134
None
0.95A 4nkvB-2gkoA:
undetectable
4nkvB-2gkoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A  79
ILE A 262
GLY A  25
ALA A  96
VAL A 134
None
0.96A 4nkvC-2gkoA:
undetectable
4nkvC-2gkoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A  79
ILE A 262
GLY A  25
ALA A  96
VAL A 134
None
0.95A 4nkvD-2gkoA:
undetectable
4nkvD-2gkoA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R1Z_A_AERA601_1
(CYP17A1 PROTEIN)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 9 ALA A  79
ILE A 262
GLY A  25
ALA A  96
VAL A 134
None
1.17A 4r1zA-2gkoA:
undetectable
4r1zA-2gkoA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_A_RBFA201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 185
ALA A 116
ILE A 119
LEU A 139
MET A 137
NA  A 614 (-4.2A)
None
None
None
None
0.98A 4r38A-2gkoA:
undetectable
4r38A-2gkoA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_C_RBFC201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 185
ALA A 116
ILE A 119
LEU A 139
MET A 137
NA  A 614 (-4.2A)
None
None
None
None
0.97A 4r38C-2gkoA:
undetectable
4r38C-2gkoA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 185
ALA A 116
ILE A 119
LEU A 139
MET A 137
NA  A 614 (-4.2A)
None
None
None
None
0.97A 4r38D-2gkoA:
undetectable
4r38D-2gkoA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 185
ALA A 116
ILE A 119
LEU A 139
MET A 137
NA  A 614 (-4.2A)
None
None
None
None
1.02A 4r3aA-2gkoA:
undetectable
4r3aA-2gkoA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 8 ALA A 155
ALA A 122
ALA A 118
ALA A 116
None
0.80A 4twdF-2gkoA:
undetectable
4twdG-2gkoA:
undetectable
4twdH-2gkoA:
undetectable
4twdI-2gkoA:
undetectable
4twdJ-2gkoA:
undetectable
4twdF-2gkoA:
22.19
4twdG-2gkoA:
22.19
4twdH-2gkoA:
22.19
4twdI-2gkoA:
22.19
4twdJ-2gkoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
4 / 8 ALA A 155
ALA A 122
ALA A 118
ALA A 116
None
0.80A 4twdF-2gkoA:
undetectable
4twdG-2gkoA:
undetectable
4twdH-2gkoA:
undetectable
4twdI-2gkoA:
undetectable
4twdJ-2gkoA:
undetectable
4twdF-2gkoA:
22.19
4twdG-2gkoA:
22.19
4twdH-2gkoA:
22.19
4twdI-2gkoA:
22.19
4twdJ-2gkoA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CPR_B_SAMB402_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1)
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
3 / 3 HIS A  71
SER A 252
ASN A 168
PMS  A 601 (-3.1A)
None
PMS  A 601 (-3.0A)
0.90A 5cprB-2gkoA:
undetectable
5cprB-2gkoA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWJ_D_QELD503_1
(NMDA GLUTAMATE
RECEPTOR SUBUNIT
GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 PRO A 173
ALA A 300
ILE A 299
THR A 194
GLU A 192
None
1.45A 5ewjC-2gkoA:
3.2
5ewjD-2gkoA:
5.1
5ewjC-2gkoA:
21.32
5ewjD-2gkoA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 165
VAL A  75
GLY A  77
ALA A  76
LEU A  98
PMS  A 601 ( 3.8A)
None
None
None
None
0.98A 5jw1A-2gkoA:
undetectable
5jw1A-2gkoA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
3 / 3 GLN A 220
THR A 213
ASP A 223
CA  A 611 (-2.9A)
CA  A 611 (-4.8A)
CA  A 611 (-2.8A)
0.76A 5k9dA-2gkoA:
undetectable
5k9dA-2gkoA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_A_RCXA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 165
VAL A  75
GLY A  77
ALA A  76
LEU A  98
PMS  A 601 ( 3.8A)
None
None
None
None
0.92A 5kirA-2gkoA:
undetectable
5kirA-2gkoA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KIR_B_RCXB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 165
VAL A  75
GLY A  77
ALA A  76
LEU A  98
PMS  A 601 ( 3.8A)
None
None
None
None
0.92A 5kirB-2gkoA:
undetectable
5kirB-2gkoA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 VAL A 188
GLU A 225
LEU A 139
ALA A 164
GLY A 222
None
1.16A 5m5cB-2gkoA:
undetectable
5m5cB-2gkoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 10 VAL A 188
GLU A 225
LEU A 139
ALA A 164
GLY A 222
None
1.16A 5m5cE-2gkoA:
undetectable
5m5cE-2gkoA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 ALA A 255
GLY A 180
ALA A 185
SER A 206
VAL A 224
None
NA  A 614 (-4.5A)
NA  A 614 (-4.2A)
None
None
0.94A 5w4zB-2gkoA:
0.8
5w4zB-2gkoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)
2gko SUBTILISIN
MICROBIAL SERINE
PROTEINASES

(Bacillus
subtilis)
5 / 12 SER A 227
ALA A 165
GLY A 247
GLY A 290
ALA A 293
None
PMS  A 601 ( 3.8A)
PMS  A 601 ( 3.8A)
None
None
0.91A 5w4zB-2gkoA:
0.8
5w4zB-2gkoA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_C_SAMC901_0
(MRNA CAPPING ENZYME
P5)
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
5 / 11 VAL A  37
GLY A  72
SER A 138
ALA A 100
LEU A  98
None
1.23A 5x6yC-2gkoA:
undetectable
5x6yC-2gkoA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DK1_B_GM4B301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)
2gko MICROBIAL SERINE
PROTEINASES
SUBTILISIN

(Bacillus
subtilis)
5 / 11 VAL A 188
ALA A 251
LEU A 278
ALA A 228
LEU A 191
None
1.29A 6dk1B-2gkoA:
undetectable
6dk1B-2gkoA:
20.06