SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gkp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LII_A_ADNA699_1
(ADENOSINE KINASE)		 2gkp HYPOTHETICAL PROTEIN
NMB0488
(Neisseria
meningitidis) 		5 / 12 ILE A 152
LEU A 115
GLY A 153
GLY A  52
LEU A 145
 None
 1.04A 1liiA-2gkpA:
undetectable		 1liiA-2gkpA:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9P_A_DESA459_1
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 2gkp HYPOTHETICAL PROTEIN
NMB0488
(Neisseria
meningitidis) 		5 / 12 LEU A  59
LEU A  56
GLU A  49
LEU A 143
ILE A 113
 None
 1.01A 1s9pA-2gkpA:
undetectable		 1s9pA-2gkpA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ONN_A_ACTA271_0
(PROTEIN SSM1)		 2gkp HYPOTHETICAL PROTEIN
NMB0488
(Neisseria
meningitidis) 		4 / 5 GLY A  52
GLU A  49
GLY A 153
PRO A 149
 None
 1.07A 3onnA-2gkpA:
undetectable		 3onnA-2gkpA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PEO_F_CU9F301_2
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2gkp HYPOTHETICAL PROTEIN
NMB0488
(Neisseria
meningitidis) 		4 / 6 THR A  24
TYR A  37
GLN A  57
SER A  26
 None
 1.15A 3peoG-2gkpA:
undetectable		 3peoG-2gkpA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2gkp HYPOTHETICAL PROTEIN
NMB0488
(Neisseria
meningitidis) 		3 / 3 GLN A  57
THR A  24
ASN A  61
 None
 0.85A 3v4tE-2gkpA:
undetectable		 3v4tE-2gkpA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 2gkp HYPOTHETICAL PROTEIN
NMB0488
(Neisseria
meningitidis) 		4 / 6 LEU A  56
GLU A  49
ILE A 122
PRO A  43
 None
 1.05A 4xi3C-2gkpA:
undetectable		 4xi3C-2gkpA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_B_REAB602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 2gkp HYPOTHETICAL PROTEIN
NMB0488
(Neisseria
meningitidis) 		5 / 9 ILE A  22
GLY A  52
LEU A 156
LEU A  59
LEU A 120
 None
 1.42A 5fhzB-2gkpA:
undetectable		 5fhzB-2gkpA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUJ_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 2gkp HYPOTHETICAL PROTEIN
NMB0488
(Neisseria
meningitidis) 		4 / 8 ALA A  58
LEU A  51
ILE A 122
VAL A 111
 None
None
None
EDO  A 402 ( 4.7A)
 0.84A 5nujA-2gkpA:
undetectable		 5nujA-2gkpA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 2gkp HYPOTHETICAL PROTEIN
NMB0488
(Neisseria
meningitidis) 		3 / 3 TRP A  10
ILE A 113
ASP A 112
 None
None
EDO  A 402 (-3.1A)
 0.91A 6i0y7-2gkpA:
undetectable		 6i0y7-2gkpA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6I0Y_A_TRPA3001_0
(23S RIBOSOMAL RNA
TRYPTOPHANASE OPERON
LEADER PEPTIDE)		 2gkp HYPOTHETICAL PROTEIN
NMB0488
(Neisseria
meningitidis) 		3 / 3 TRP A  25
ILE A 113
ASP A 112
 NA  A 403 (-4.4A)
None
EDO  A 402 (-3.1A)
 0.67A 6i0y7-2gkpA:
undetectable		 6i0y7-2gkpA:
9.21