SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gks'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PJ7_A_FFOA2887_1
(N,N-DIMETHYLGLYCINE
OXIDASE)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		3 / 3 ASP A  19
THR A  60
GLU A 103
 None
 0.76A 1pj7A-2gksA:
undetectable		 1pj7A-2gksA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		5 / 12 ALA A  27
LEU A 237
ILE A  57
ARG A  15
ILE A  59
 None
 1.08A 1ra3A-2gksA:
undetectable		 1ra3A-2gksA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TUV_A_VK3A4558_1
(PROTEIN YGIN)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		4 / 7 TYR A 281
HIS A 115
LEU A 117
ILE A  57
 None
 1.14A 1tuvA-2gksA:
undetectable		 1tuvA-2gksA:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AA5_B_STRB302_1
(MINERALOCORTICOID
RECEPTOR)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		5 / 12 LEU A 108
ALA A 269
GLN A 170
LEU A 237
ARG A 254
 None
ADP  A 902 (-4.4A)
ADP  A 902 (-3.6A)
None
None
 1.35A 2aa5B-2gksA:
undetectable		 2aa5B-2gksA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJF_B_ADNB2002_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		4 / 6 ARG A 266
GLU A 285
PRO A 244
ALA A 247
 ADP  A 902 (-4.3A)
None
None
None
 0.96A 2ejfB-2gksA:
undetectable		 2ejfB-2gksA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJG_A_ADNA1501_1
(235AA LONG
HYPOTHETICAL
BIOTIN--[ACETYL-COA-
CARBOXYLASE] LIGASE)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		4 / 7 ARG A 266
GLU A 285
PRO A 244
ALA A 247
 ADP  A 902 (-4.3A)
None
None
None
 1.04A 2ejgA-2gksA:
undetectable		 2ejgA-2gksA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_D_SNLD4001_1
(MINERALOCORTICOID
RECEPTOR)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		5 / 12 LEU A 108
ALA A 269
GLN A 170
LEU A 237
ARG A 254
 None
ADP  A 902 (-4.4A)
ADP  A 902 (-3.6A)
None
None
 1.36A 2oaxD-2gksA:
undetectable		 2oaxD-2gksA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_E_SNLE5001_1
(MINERALOCORTICOID
RECEPTOR)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		5 / 12 LEU A 108
ALA A 269
GLN A 170
LEU A 237
ARG A 254
 None
ADP  A 902 (-4.4A)
ADP  A 902 (-3.6A)
None
None
 1.31A 2oaxE-2gksA:
undetectable		 2oaxE-2gksA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BVB_B_017B401_1
(PROTEASE
(RETROPEPSIN))		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		6 / 12 LEU A   7
GLY A  74
ILE A 129
GLY A 131
VAL A  78
ILE A  77
 None
 1.15A 3bvbA-2gksA:
undetectable		 3bvbA-2gksA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		4 / 6 TYR A 221
THR A 230
LEU A 194
GLU A 157
 None
 0.88A 3ps9A-2gksA:
undetectable		 3ps9A-2gksA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VHU_A_SNLA1001_1
(MINERALOCORTICOID
RECEPTOR)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		5 / 12 LEU A 108
ALA A 269
GLN A 170
LEU A 237
ARG A 254
 None
ADP  A 902 (-4.4A)
ADP  A 902 (-3.6A)
None
None
 1.40A 3vhuA-2gksA:
undetectable		 3vhuA-2gksA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		4 / 7 PHE A 471
VAL A 462
ILE A 430
GLU A 517
 None
 1.12A 4a97H-2gksA:
undetectable		 4a97H-2gksA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC0_A_MIYA1204_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS B FROM
TRANSPOSON TN1 0)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		5 / 12 HIS A 197
HIS A 250
ARG A 240
LEU A  22
LEU A  31
 None
 1.47A 4ac0A-2gksA:
0.0		 4ac0A-2gksA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DUZ_A_SRYA1601_1
(16S RRNA
RIBOSOMAL PROTEIN
S12)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		3 / 3 LYS A 370
PRO A 367
LYS A 545
 None
 1.27A 4duzL-2gksA:
0.0		 4duzL-2gksA:
13.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		4 / 6 ASN A  42
GLU A  37
TYR A  40
GLU A  45
 None
 1.38A 4mi4A-2gksA:
undetectable		 4mi4A-2gksA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R21_B_STRB601_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		5 / 9 ILE A 430
GLY A 434
ALA A 437
ILE A 448
VAL A 411
 None
 1.10A 4r21B-2gksA:
undetectable		 4r21B-2gksA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R82_A_ACTA205_0
(OXIDOREDUCTASE)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		4 / 5 SER A 130
GLY A  36
ARG A  33
GLU A  93
 None
 1.33A 4r82A-2gksA:
1.7
4r82B-2gksA:
undetectable		 4r82A-2gksA:
15.68
4r82B-2gksA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		3 / 3 TYR A 127
LYS A  69
LYS A  65
 None
 0.95A 5dbyA-2gksA:
undetectable		 5dbyA-2gksA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DPD_A_SAMA601_0
(PROTEIN LYSINE
METHYLTRANSFERASE 1)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		5 / 12 GLU A  64
LEU A  79
GLN A  11
ILE A 129
VAL A  92
 None
 1.09A 5dpdA-2gksA:
undetectable		 5dpdA-2gksA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		4 / 6 TYR A 141
TYR A 211
GLY A 201
ASP A  19
 None
 1.20A 5emlA-2gksA:
2.8		 5emlA-2gksA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 2gks BIFUNCTIONAL SAT/APS
KINASE
(Aquifex
aeolicus) 		5 / 10 LEU A 535
ILE A 544
ARG A 399
PHE A 373
VAL A 375
 None
 1.29A 5m0oA-2gksA:
undetectable		 5m0oA-2gksA:
22.38