SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gkw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_C_9CRC502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
(Homo
sapiens) 		5 / 10 LEU A 444
PHE A 473
LEU A 407
PHE A 491
ILE A 490
 None
 1.00A 1g5yC-2gkwA:
undetectable		 1g5yC-2gkwA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XZX_X_T3X500_2
(THYROID HORMONE
RECEPTOR BETA-1)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
(Homo
sapiens) 		3 / 3 PHE A 426
ARG A 415
ASN A 465
 None
 0.93A 1xzxX-2gkwA:
undetectable		 1xzxX-2gkwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_A_SVRA508_1
(PHOSPHOLIPASE A2)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
13C
(;
Homo
sapiens) 		4 / 5 VAL B 174
GLN A 343
PHE A 381
ARG A 364
 None
 1.14A 3bjwE-2gkwB:
undetectable		 3bjwE-2gkwB:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_2
(PHOSPHOLIPASE A2)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
13C
(;
Homo
sapiens) 		4 / 6 VAL B 174
GLN A 343
PHE A 381
ARG A 364
 None
 1.20A 3bjwF-2gkwB:
undetectable		 3bjwF-2gkwB:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_F_SVRF502_2
(PHOSPHOLIPASE A2)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
13C
(;
Homo
sapiens) 		4 / 5 ILE A 466
SER A 468
PRO B 164
PRO B 162
 None
 1.31A 3bjwC-2gkwA:
undetectable		 3bjwC-2gkwA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
13C
(;
Homo
sapiens) 		5 / 12 LEU A 396
ALA A 392
ALA B 165
GLY A 398
ILE A 358
 None
 1.00A 3c6gA-2gkwA:
undetectable		 3c6gA-2gkwA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IXL_A_PACA5000_0
(ARYLMALONATE
DECARBOXYLASE)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
13C
(Homo
sapiens;
) 		5 / 10 THR B 166
TYR A 395
VAL A 472
GLY A 400
GLY A 402
 None
 1.19A 3ixlA-2gkwB:
undetectable		 3ixlA-2gkwB:
7.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_C_C2FC1410_0
(GLYCINE
N-METHYLTRANSFERASE)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
13C
(Homo
sapiens;
) 		3 / 3 ARG A 393
PRO B 164
PHE A 410
 None
 1.02A 3thrC-2gkwA:
undetectable		 3thrC-2gkwA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_A_RGZA601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
(Homo
sapiens) 		5 / 11 LEU A 396
LEU A 434
ILE A 485
GLN A 437
ILE A 358
 None
 1.49A 4a7aA-2gkwA:
undetectable		 4a7aA-2gkwA:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTA_G_MFXG101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
(Homo
sapiens) 		4 / 7 SER A 454
ASP A 419
GLY A 462
GLU A 463
 None
 0.99A 5btaA-2gkwA:
undetectable
5btaC-2gkwA:
undetectable
5btaD-2gkwA:
undetectable		 5btaA-2gkwA:
17.36
5btaC-2gkwA:
17.36
5btaD-2gkwA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BTF_F_GFNF101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
DNA SUBSTRATE 24-MER
TTACGTGCATAGTCATTCAT
GACC)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
(Homo
sapiens) 		4 / 7 SER A 454
ASP A 419
GLY A 462
GLU A 463
 None
 0.94A 5btfA-2gkwA:
undetectable
5btfB-2gkwA:
undetectable
5btfC-2gkwA:
undetectable		 5btfA-2gkwA:
17.36
5btfB-2gkwA:
22.43
5btfC-2gkwA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKL_B_SAMB8009_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN,HISTONE H3.1
PEPTIDE,ZINC FINGER
DOMAIN-CONTAINING
PROTEIN)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
(Homo
sapiens) 		5 / 12 LEU A 354
GLY A 352
TYR A 388
PHE A 448
LEU A 432
 None
 1.31A 5kklB-2gkwA:
undetectable		 5kklB-2gkwA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gkw TNF
RECEPTOR-ASSOCIATED
FACTOR 3
(Homo
sapiens) 		4 / 7 ILE A 492
LEU A 434
ARG A 393
LEU A 396
 None
 0.95A 6nmpA-2gkwA:
undetectable
6nmpJ-2gkwA:
undetectable		 6nmpA-2gkwA:
16.87
6nmpJ-2gkwA:
19.05