SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gl5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		5 / 8 ILE A  57
LEU A  60
MET A  97
ILE A 100
ILE A  28
 None
 1.38A 1linA-2gl5A:
undetectable		 1linA-2gl5A:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_B_DIFB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		5 / 9 LEU A  60
VAL A  92
GLY A  96
ALA A  95
SER A  98
 None
 1.22A 1pxxB-2gl5A:
undetectable		 1pxxB-2gl5A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UKB_A_BEZA1300_0
(2-HYDROXY-6-OXO-7-ME
THYLOCTA-2,4-DIENOAT
E HYDROLASE)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		5 / 11 GLY A  96
ALA A  99
ALA A 103
LEU A 104
VAL A   8
 None
 1.12A 1ukbA-2gl5A:
undetectable		 1ukbA-2gl5A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DXR_A_SORA1002_0
(LACTOTRANSFERRIN)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		3 / 3 THR A 272
PRO A 296
TYR A 282
 None
 0.90A 2dxrA-2gl5A:
undetectable		 2dxrA-2gl5A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		5 / 8 TYR A 164
GLY A 138
GLY A 140
ALA A 159
ALA A 158
 None
 1.29A 2ej3C-2gl5A:
undetectable		 2ej3C-2gl5A:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B235_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 6 PHE A  80
TRP A  76
GLY A  90
GLY A  89
 None
 1.00A 2qr2A-2gl5A:
undetectable
2qr2B-2gl5A:
undetectable		 2qr2A-2gl5A:
21.60
2qr2B-2gl5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QR2_B_VK3B236_1
(PROTEIN (QUINONE
REDUCTASE TYPE 2))		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 5 TRP A  76
GLY A  90
GLY A  89
PHE A  80
 None
 1.02A 2qr2A-2gl5A:
undetectable
2qr2B-2gl5A:
undetectable		 2qr2A-2gl5A:
21.60
2qr2B-2gl5A:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEY_A_EV1A1771_1
(CAMP AND
CAMP-INHIBITED CGMP
3', 5'-CYCLIC
PHOSPHODIESTERASE)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		5 / 12 LEU A 194
LEU A 172
ILE A 239
TYR A 242
GLU A 240
 None
 1.24A 2weyA-2gl5A:
undetectable		 2weyA-2gl5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 5 ALA A 341
GLY A 307
CYH A 311
LYS A 309
 None
 1.32A 2yldA-2gl5A:
undetectable		 2yldA-2gl5A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 5 ALA A 341
GLY A 307
CYH A 311
LYS A 309
 None
 1.31A 2ylgA-2gl5A:
undetectable		 2ylgA-2gl5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		3 / 3 MET A  20
CYH A 326
PRO A  25
 None
 1.16A 3h52C-2gl5A:
undetectable		 3h52C-2gl5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		5 / 12 GLY A  43
GLY A  96
ALA A  50
GLY A  49
ILE A  56
 None
 0.94A 3ku1C-2gl5A:
undetectable		 3ku1C-2gl5A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_A_BEZA264_0
(ECHA1_1)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 8 ILE A 206
ALA A 156
ALA A 155
MET A 213
 None
 0.58A 3r9tA-2gl5A:
1.5		 3r9tA-2gl5A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9T_B_BEZB264_0
(ECHA1_1)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 7 ILE A 206
ALA A 156
ALA A 155
MET A 213
 None
 0.62A 3r9tB-2gl5A:
1.5		 3r9tB-2gl5A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_A_ROCA201_2
(PROTEASE)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		5 / 9 LEU A  60
GLY A  40
ILE A 102
ILE A  56
ILE A  57
 None
 1.11A 3s56B-2gl5A:
undetectable		 3s56B-2gl5A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 5 ALA A 341
GLY A 307
CYH A 311
LYS A 309
 None
 1.36A 3zwiA-2gl5A:
undetectable		 3zwiA-2gl5A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 8 LEU A 194
ILE A 223
VAL A 221
GLY A 202
 None
 0.86A 4eq4B-2gl5A:
undetectable		 4eq4B-2gl5A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LB2_A_DM5A601_1
(SERUM ALBUMIN)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 7 LEU A 128
VAL A 375
PRO A 377
GLU A 339
 None
 1.01A 4lb2A-2gl5A:
undetectable		 4lb2A-2gl5A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_1
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		5 / 12 ASP A 170
VAL A 169
PHE A 137
ASP A 180
GLY A 138
 None
 1.34A 4pevC-2gl5A:
undetectable		 4pevC-2gl5A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_ACTC202_0
(RETINOL-BINDING
PROTEIN 2)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 6 TYR A 277
GLU A 249
THR A 272
LEU A 300
 None
 1.42A 4qzuC-2gl5A:
undetectable		 4qzuC-2gl5A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 5 GLU A 389
GLU A 393
TYR A 394
GLU A 361
 None
 0.99A 4r87E-2gl5A:
undetectable		 4r87E-2gl5A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 7 GLU A 389
GLU A 393
TYR A 394
GLU A 361
 None
 1.06A 4r87I-2gl5A:
1.7		 4r87I-2gl5A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_1
(HYDG PROTEIN)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		3 / 3 GLU A 274
ARG A 275
GLN A 134
 MG  A 699 (-2.6A)
None
MG  A 699 ( 4.9A)
 0.90A 4rtbA-2gl5A:
5.4		 4rtbA-2gl5A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UW0_A_SAMA1506_0
(WBDD)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		5 / 12 GLY A  53
ALA A  50
ILE A  57
VAL A  42
ILE A  28
 None
 1.04A 4uw0A-2gl5A:
2.9		 4uw0A-2gl5A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 4 ILE A 244
ILE A 219
ARG A 210
LEU A 246
 None
 1.07A 5dzkh-2gl5A:
3.2
5dzkn-2gl5A:
3.3
5dzkv-2gl5A:
undetectable		 5dzkh-2gl5A:
20.25
5dzkn-2gl5A:
20.25
5dzkv-2gl5A:
1.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 5 ALA A 341
GLY A 307
CYH A 311
LYS A 309
 None
 1.28A 5jliA-2gl5A:
undetectable		 5jliA-2gl5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 5 ALA A 341
GLY A 307
CYH A 311
LYS A 309
 None
 1.29A 5jt4A-2gl5A:
undetectable		 5jt4A-2gl5A:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		5 / 12 ARG A 275
ILE A 310
ALA A 314
THR A 319
ALA A 271
 None
 1.13A 5veuA-2gl5A:
undetectable		 5veuA-2gl5A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA410_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 4 GLY A  40
LEU A  27
VAL A 330
GLU A  41
 None
 1.22A 5yw0A-2gl5A:
undetectable		 5yw0A-2gl5A:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6IFT_A_SAMA301_1
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE A)		 2gl5 PUTATIVE DEHYDRATASE
PROTEIN
(Salmonella
enterica) 		4 / 5 GLN A 134
GLU A 349
ASP A 297
TYR A  46
 MG  A 699 ( 4.9A)
None
None
None
 1.07A 6iftA-2gl5A:
0.0		 6iftA-2gl5A:
21.82