SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gli'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 2gli PROTEIN (FIVE-FINGER
GLI)
(Homo
sapiens) 		3 / 3 ARG A 183
VAL A 122
THR A 165
 None
 0.78A 3cyxA-2gliA:
undetectable		 3cyxA-2gliA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 2gli PROTEIN (FIVE-FINGER
GLI)
(Homo
sapiens) 		3 / 3 SER A 117
PHE A 115
LYS A 103
 None
 1.01A 3u88A-2gliA:
undetectable		 3u88A-2gliA:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 2gli PROTEIN (FIVE-FINGER
GLI)
(Homo
sapiens) 		4 / 5 LEU A 148
HIS A 140
HIS A 160
HIS A 164
 None
None
CO  A 259 (-3.2A)
CO  A 259 (-3.1A)
 1.20A 4a7bB-2gliA:
undetectable		 4a7bB-2gliA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V9J_B_SAMB1301_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1)		 2gli PROTEIN (FIVE-FINGER
GLI)
(Homo
sapiens) 		5 / 12 GLY A 166
SER A 117
HIS A 124
CYH A 106
ARG A 107
 None
None
CO  A 258 (-3.2A)
CO  A 258 (-2.2A)
None
 1.33A 5v9jB-2gliA:
undetectable		 5v9jB-2gliA:
18.75