SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2glj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		5 / 10 CYH A 433
ASP A 266
THR A 418
THR A 373
ILE A 431
 None
MN  A6002 ( 4.9A)
None
None
None
 1.32A 1i18A-2gljA:
undetectable
1i18B-2gljA:
undetectable		 1i18A-2gljA:
14.93
1i18B-2gljA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_B_RBFB99_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		5 / 10 ILE A 431
CYH A 433
ASP A 266
THR A 418
THR A 373
 None
None
MN  A6002 ( 4.9A)
None
None
 1.31A 1i18A-2gljA:
undetectable
1i18B-2gljA:
undetectable		 1i18A-2gljA:
14.93
1i18B-2gljA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		3 / 3 GLU A 128
GLU A 233
LEU A 202
 None
 0.77A 1v8bB-2gljA:
undetectable		 1v8bB-2gljA:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		4 / 5 PRO A 245
GLY A 263
ASN A  37
GLY A 261
 None
 1.09A 1zlqA-2gljA:
undetectable		 1zlqA-2gljA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B9E_A_SAMA1201_0
(NOL1/NOP2/SUN DOMAIN
FAMILY, MEMBER 5
ISOFORM 2)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		5 / 12 GLY A 366
ASN A 402
LEU A 438
ASP A 348
PHE A 347
 None
 1.34A 2b9eA-2gljA:
undetectable		 2b9eA-2gljA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		5 / 10 ILE A 221
ILE A 201
LEU A 225
ASN A 220
VAL A 163
 None
 1.11A 2nnhB-2gljA:
undetectable		 2nnhB-2gljA:
23.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBU_D_ADND504_1
(UNCHARACTERIZED
CONSERVED PROTEIN)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		3 / 3 PHE A 309
ASN A 312
PHE A  88
 None
 1.05A 2zbuD-2gljA:
undetectable		 2zbuD-2gljA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AVP_A_MV2A313_1
(PANTOTHENATE KINASE)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		4 / 7 ASP A 342
HIS A 105
LEU A 437
TYR A 262
 MN  A6002 (-2.0A)
MN  A6002 (-3.4A)
None
None
 1.03A 3avpA-2gljA:
undetectable		 3avpA-2gljA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_A_SAMA1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		5 / 12 THR A 157
VAL A 152
ILE A 151
ILE A 231
SER A 232
 None
 1.17A 3kpbA-2gljA:
undetectable		 3kpbA-2gljA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_C_SAMC1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		5 / 12 THR A 157
VAL A 152
ILE A 151
ILE A 231
SER A 232
 None
 1.19A 3kpbC-2gljA:
undetectable		 3kpbC-2gljA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		4 / 8 SER A 299
ILE A 422
SER A 340
ASP A 107
 None
 0.71A 3pwwA-2gljA:
undetectable		 3pwwA-2gljA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		4 / 8 PHE A  88
ALA A  78
ASN A 312
PHE A 309
 None
 1.00A 3t3sF-2gljA:
undetectable		 3t3sF-2gljA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_4
(PROTEASE)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		4 / 4 ASP A 293
ASP A 107
GLY A 298
THR A 418
 None
 1.38A 3tl9B-2gljA:
undetectable		 3tl9B-2gljA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_B_CVIB301_0
(PUTATIVE REGULATORY
PROTEIN)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		5 / 12 LEU A 225
ILE A 151
ILE A 221
ALA A 125
LEU A 127
 None
 1.40A 3vw1B-2gljA:
undetectable		 3vw1B-2gljA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG306_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		3 / 3 ARG A 110
ARG A 267
ASP A 293
 None
 0.64A 3wipG-2gljA:
undetectable
3wipH-2gljA:
undetectable		 3wipG-2gljA:
17.77
3wipH-2gljA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HVR_A_SALA203_1
(3-HYDROXYANTHRANILAT
E 3,4-DIOXYGENASE)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		4 / 7 ASP A 265
GLU A 296
HIS A 441
GLU A 295
 MN  A6002 ( 2.9A)
MN  A6001 ( 2.2A)
MN  A6001 (-4.1A)
MN  A6002 (-3.1A)
 1.01A 4hvrA-2gljA:
undetectable		 4hvrA-2gljA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J7X_A_SASA806_1
(SEPIAPTERIN
REDUCTASE)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		5 / 12 LEU A 438
GLN A 404
ALA A 406
ASP A 342
GLY A 434
 None
None
None
MN  A6002 (-2.0A)
None
 1.41A 4j7xA-2gljA:
undetectable		 4j7xA-2gljA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		6 / 11 HIS A 105
ASP A 265
GLU A 295
GLU A 296
GLY A 416
HIS A 441
 MN  A6002 (-3.4A)
MN  A6002 ( 2.9A)
MN  A6002 (-3.1A)
MN  A6001 ( 2.2A)
None
MN  A6001 (-4.1A)
 0.78A 4pqaA-2gljA:
19.7		 4pqaA-2gljA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PQA_A_X8ZA401_1
(SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		6 / 11 HIS A 105
ASP A 265
GLU A 295
GLY A 415
GLY A 416
HIS A 441
 MN  A6002 (-3.4A)
MN  A6002 ( 2.9A)
MN  A6002 (-3.1A)
None
None
MN  A6001 (-4.1A)
 1.22A 4pqaA-2gljA:
19.7		 4pqaA-2gljA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		4 / 9 SER A 273
ALA A 276
GLU A 279
ILE A 452
 None
 0.81A 4xtaA-2gljA:
undetectable		 4xtaA-2gljA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AMI_B_EF2B151_1
(CEREBLON ISOFORM 4)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		4 / 8 ASN A 116
PRO A 117
PHE A 236
SER A 238
 None
 1.38A 5amiB-2gljA:
undetectable		 5amiB-2gljA:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		3 / 3 LEU A 118
LEU A 225
ARG A  42
 None
 0.60A 5hnzB-2gljA:
undetectable		 5hnzB-2gljA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 2glj PROBABLE M18-FAMILY
AMINOPEPTIDASE 1
(Clostridium
acetobutylicum) 		4 / 5 SER A 344
ASN A  33
GLN A 264
ASP A  29
 None
 1.48A 5kpcA-2gljA:
undetectable		 5kpcA-2gljA:
22.33