SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2glw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_0
(WNT INHIBITORY
FACTOR 1)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
5 / 12 LEU A  84
ILE A  39
ILE A  37
PHE A  52
PHE A   7
None
0.94A 2ygoA-2glwA:
undetectable
2ygoA-2glwA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DEU_A_SALA305_1
(TRANSCRIPTIONAL
REGULATOR SLYA)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
4 / 7 VAL A  62
ILE A  64
ILE A  39
THR A   9
None
0.88A 3deuA-2glwA:
undetectable
3deuA-2glwA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKV_A_478A200_2
(PROTEASE)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
5 / 9 ALA A  54
GLY A  60
ILE A  18
VAL A  82
ILE A  37
None
1.00A 3ekvB-2glwA:
undetectable
3ekvB-2glwA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU4_B_478B401_1
(PROTEASE)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
5 / 9 ALA A  54
GLY A  60
ILE A  18
VAL A  82
ILE A  37
None
0.98A 3nu4A-2glwA:
undetectable
3nu4A-2glwA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU6_B_478B401_1
(PROTEASE)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
5 / 10 ALA A  54
GLY A  60
ILE A  18
VAL A  82
ILE A  37
None
0.98A 3nu6A-2glwA:
undetectable
3nu6A-2glwA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUJ_B_478B401_1
(PROTEASE)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
5 / 10 ALA A  54
GLY A  60
ILE A  18
VAL A  82
ILE A  37
None
1.02A 3nujA-2glwA:
undetectable
3nujA-2glwA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NUO_B_478B478_1
(PROTEASE)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
5 / 9 ALA A  54
GLY A  60
ILE A  18
VAL A  82
ILE A  37
None
1.01A 3nuoA-2glwA:
undetectable
3nuoA-2glwA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
5 / 10 ALA A  54
GLY A  60
ILE A  18
VAL A  82
ILE A  37
None
1.08A 4dqcA-2glwA:
undetectable
4dqcA-2glwA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q1W_A_017A104_2
(ASPARTYL PROTEASE)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
5 / 10 ALA A  54
GLY A  60
ILE A  18
VAL A  82
ILE A  37
None
1.02A 4q1wB-2glwA:
undetectable
4q1wB-2glwA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
5 / 9 ALA A  54
GLY A  60
ILE A  18
VAL A  82
ILE A  37
None
0.99A 5kr0A-2glwA:
undetectable
5kr0A-2glwA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR0_A_478A101_1
(PROTEASE E35D-APV)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
5 / 9 ALA A  54
ILE A  29
GLY A  60
VAL A  82
ILE A  37
None
1.05A 5kr0A-2glwA:
undetectable
5kr0A-2glwA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CDU_G_EY4G501_0
(CHIMERIC ALPHA1GABAA
RECEPTOR)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
4 / 7 ILE A  19
VAL A  62
ILE A  37
THR A  53
None
0.94A 6cduF-2glwA:
undetectable
6cduG-2glwA:
undetectable
6cduF-2glwA:
12.92
6cduG-2glwA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii)
6 / 10 ALA A  54
ILE A  29
GLY A  60
ILE A  18
VAL A  82
ILE A  37
None
1.09A 6dj2A-2glwA:
undetectable
6dj2A-2glwA:
21.05