SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gm8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HZ4_A_BEZA784_0
(MALT REGULATORY
PROTEIN)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 6 LEU A  26
LEU A  31
PRO A  32
MET A  33
 None
 1.27A 1hz4A-2gm8A:
undetectable		 1hz4A-2gm8A:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 8 TYR A  85
LEU A  40
LEU A  96
GLU A  91
 None
 1.01A 1i7zA-2gm8A:
undetectable		 1i7zA-2gm8A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KXH_A_ACRA598_2
(ALPHA-AMYLASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		3 / 3 TRP A 160
TYR A 157
LEU A 149
 None
 0.94A 1kxhA-2gm8A:
undetectable		 1kxhA-2gm8A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 7 TYR A  85
TRP A 160
HIS A 145
TYR A  27
 None
 1.19A 1mxgA-2gm8A:
undetectable		 1mxgA-2gm8A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MXG_A_ACRA444_1
(ALPHA AMYLASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 7 TYR A  85
TRP A 160
TYR A  27
GLY A  29
 None
 1.22A 1mxgA-2gm8A:
undetectable		 1mxgA-2gm8A:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_B_ACTB1294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 7 TRP A 205
TYR A 138
TYR A 164
TYR A  85
 None
HMH  A 301 (-3.3A)
None
None
 1.37A 1nbhB-2gm8A:
undetectable		 1nbhB-2gm8A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBH_D_ACTD3294_0
(GLYCINE
N-METHYLTRANSFERASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 7 TRP A 205
TYR A 138
TYR A 164
TYR A  85
 None
HMH  A 301 (-3.3A)
None
None
 1.37A 1nbhD-2gm8A:
undetectable		 1nbhD-2gm8A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_A_SCKA901_1
(ACETYLCHOLINESTERASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 8 TYR A  46
ASP A  43
TYR A 138
HIS A  20
 HMH  A 301 (-3.6A)
HMH  A 301 (-2.6A)
HMH  A 301 (-3.3A)
None
 1.37A 2ha2A-2gm8A:
undetectable		 2ha2A-2gm8A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HA2_B_SCKB951_1
(ACETYLCHOLINESTERASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 8 TYR A  46
ASP A  43
TYR A 138
HIS A  20
 HMH  A 301 (-3.6A)
HMH  A 301 (-2.6A)
HMH  A 301 (-3.3A)
None
 1.38A 2ha2B-2gm8A:
undetectable		 2ha2B-2gm8A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W8Y_A_486A1000_2
(PROGESTERONE
RECEPTOR)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 7 LEU A 131
GLU A 122
LEU A 121
TYR A  46
 None
None
None
HMH  A 301 (-3.6A)
 1.21A 2w8yA-2gm8A:
undetectable		 2w8yA-2gm8A:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 8 SER A 183
LEU A 190
LEU A   6
VAL A   2
 None
 0.87A 3dcjB-2gm8A:
undetectable		 3dcjB-2gm8A:
26.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX1_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 8 GLU A 188
SER A 186
ARG A   8
VAL A   2
 None
 1.38A 3jx1A-2gm8A:
undetectable
3jx1B-2gm8A:
undetectable		 3jx1A-2gm8A:
19.25
3jx1B-2gm8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_H_TFPH202_1
(PROTEIN S100-A4)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		5 / 12 GLU A 140
LEU A  18
ILE A 141
PHE A 135
PHE A 194
 None
None
None
HMH  A 301 ( 4.9A)
None
 1.46A 3ko0G-2gm8A:
1.3
3ko0H-2gm8A:
1.3
3ko0I-2gm8A:
1.3
3ko0J-2gm8A:
1.3		 3ko0G-2gm8A:
20.23
3ko0H-2gm8A:
20.23
3ko0I-2gm8A:
20.23
3ko0J-2gm8A:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXV_A_478A200_1
(HIV-1 PROTEASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 6 TRP A  14
PRO A 133
ARG A   7
GLY A   4
 None
 1.41A 3oxvA-2gm8A:
undetectable		 3oxvA-2gm8A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S53_B_017B203_1
(PROTEASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 5 TRP A  14
PRO A 133
ARG A   7
GLY A   4
 None
 1.40A 3s53B-2gm8A:
undetectable		 3s53B-2gm8A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_A_9PLA1_1
(CYTOCHROME P450 2A13)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		5 / 9 PHE A 124
ALA A  57
PHE A 135
ALA A  74
THR A  77
 None
None
HMH  A 301 ( 4.9A)
None
None
 1.27A 3t3sA-2gm8A:
0.0		 3t3sA-2gm8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3S_F_9PLF1_1
(CYTOCHROME P450 2A13)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		5 / 8 PHE A 124
ALA A  57
PHE A 135
ALA A  74
THR A  77
 None
None
HMH  A 301 ( 4.9A)
None
None
 1.22A 3t3sF-2gm8A:
undetectable		 3t3sF-2gm8A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CAP_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 8 GLU A 188
SER A 186
ARG A   8
VAL A   2
 None
 1.39A 4capA-2gm8A:
1.4
4capB-2gm8A:
undetectable		 4capA-2gm8A:
19.25
4capB-2gm8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LG1_C_SAMC301_0
(PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21D)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		5 / 12 GLY A  80
GLY A  76
LEU A  47
TYR A 169
TYR A 164
 None
None
HMH  A 301 (-4.6A)
None
None
 1.16A 4lg1C-2gm8A:
undetectable		 4lg1C-2gm8A:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V3Y_B_H4BB760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 8 GLU A 188
SER A 186
ARG A   8
VAL A   2
 None
 1.38A 4v3yA-2gm8A:
undetectable
4v3yB-2gm8A:
1.0		 4v3yA-2gm8A:
19.25
4v3yB-2gm8A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC608_1
(ALPHA-AMYLASE)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		3 / 3 TYR A 114
ALA A 120
LEU A 121
 None
 0.68A 6ag0C-2gm8A:
undetectable		 6ag0C-2gm8A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BC9_A_ETSA302_2
(CARBONIC ANHYDRASE 2)		 2gm8 TENA HOMOLOG/THI-4
THIAMINASE
(Pyrobaculum
aerophilum) 		4 / 5 HIS A  -1
GLU A 140
LEU A 176
VAL A 173
 None
 1.17A 6bc9A-2gm8A:
undetectable		 6bc9A-2gm8A:
20.10