SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gmi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AKE_A_TRPA479_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		5 / 12 THR B  44
GLY B  43
GLY B  29
ILE B  45
CYH B  26
 None
 1.17A 2akeA-2gmiB:
undetectable		 2akeA-2gmiB:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_A_TRPA601_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		5 / 12 THR B  44
GLY B  43
GLY B  29
ILE B  45
CYH B  26
 None
 1.19A 2azxA-2gmiB:
undetectable		 2azxA-2gmiB:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AZX_B_TRPB603_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		5 / 12 THR B  44
GLY B  43
GLY B  29
ILE B  45
CYH B  26
 None
 1.18A 2azxB-2gmiB:
undetectable		 2azxB-2gmiB:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_A_IPHA2001_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13
(Saccharomyces
cerevisiae) 		4 / 5 HIS A  77
PRO A  78
TYR A  47
PRO A  46
 None
 1.43A 2ombA-2gmiA:
undetectable
2ombB-2gmiA:
undetectable		 2ombA-2gmiA:
21.52
2ombB-2gmiA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X9G_A_LYAA1270_2
(PTERIDINE REDUCTASE)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13
(Saccharomyces
cerevisiae) 		3 / 3 MET A  64
VAL A  69
GLU A  11
 None
 0.92A 2x9gA-2gmiA:
undetectable		 2x9gA-2gmiA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD201_1
(PROTEIN S100-A4)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		4 / 8 GLY B  43
CYH B  85
PHE B  77
PHE B 137
 None
 1.01A 3ko0D-2gmiB:
undetectable
3ko0E-2gmiB:
undetectable		 3ko0D-2gmiB:
20.15
3ko0E-2gmiB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_J_TFPJ201_1
(PROTEIN S100-A4)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		4 / 8 PHE B  77
PHE B 137
GLY B  43
CYH B  85
 None
 1.00A 3ko0B-2gmiB:
undetectable
3ko0J-2gmiB:
1.0		 3ko0B-2gmiB:
20.15
3ko0J-2gmiB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		4 / 7 GLY B  43
CYH B  85
PHE B  77
PHE B 137
 None
 0.94A 3ko0L-2gmiB:
undetectable
3ko0N-2gmiB:
undetectable		 3ko0L-2gmiB:
20.15
3ko0N-2gmiB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		4 / 8 GLY B  43
CYH B  85
PHE B  77
PHE B 137
 None
 0.96A 3ko0O-2gmiB:
undetectable
3ko0Q-2gmiB:
undetectable		 3ko0O-2gmiB:
20.15
3ko0Q-2gmiB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		4 / 7 PHE B  77
PHE B 137
GLY B  43
CYH B  85
 None
 0.98A 3ko0K-2gmiB:
1.1
3ko0S-2gmiB:
1.0		 3ko0K-2gmiB:
20.15
3ko0S-2gmiB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		4 / 7 PHE B  77
PHE B 137
GLY B  43
CYH B  85
 None
 0.92A 3ko0R-2gmiB:
undetectable
3ko0T-2gmiB:
1.2		 3ko0R-2gmiB:
20.15
3ko0T-2gmiB:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13
(Saccharomyces
cerevisiae) 		5 / 12 LEU A  91
ILE A   8
ILE A 101
VAL A 104
LEU A 105
 None
 1.06A 3w67B-2gmiA:
undetectable		 3w67B-2gmiA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_2
(ESTROGEN RECEPTOR)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13
(Saccharomyces
cerevisiae) 		4 / 6 LEU A  54
LEU A  91
PHE A  71
LEU A 111
 None
 0.94A 5gs4A-2gmiA:
undetectable		 5gs4A-2gmiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GTR_A_ESTA601_2
(ESTROGEN RECEPTOR)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13
(Saccharomyces
cerevisiae) 		4 / 5 LEU A  54
LEU A  91
PHE A  71
LEU A 111
 None
 0.91A 5gtrA-2gmiA:
undetectable		 5gtrA-2gmiA:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		5 / 6 THR B  90
GLY B  91
GLU B  92
PHE B  77
ILE B  62
 None
 1.44A 5kmfA-2gmiB:
undetectable
5kmfC-2gmiB:
undetectable		 5kmfA-2gmiB:
19.79
5kmfC-2gmiB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OH1_C_9UQC202_0
(CEREBLON ISOFORM 4)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13
(Saccharomyces
cerevisiae) 		4 / 8 ASN A 116
PRO A 117
GLU A 133
TYR A  47
 None
 0.98A 5oh1C-2gmiA:
undetectable		 5oh1C-2gmiA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA312_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME E2 13
(Saccharomyces
cerevisiae) 		3 / 3 ILE A  86
VAL A  69
PRO A  67
 None
 0.57A 5uunA-2gmiA:
undetectable		 5uunA-2gmiA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7Z_A_BHAA201_0
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		4 / 6 LEU B  60
VAL B  75
LEU B 112
VAL B  93
 None
 0.98A 5x7zA-2gmiB:
undetectable		 5x7zA-2gmiB:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_A_TRPA403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		4 / 8 ARG B 117
THR B 122
PRO B 123
PRO B  84
 None
 1.06A 6a4iA-2gmiB:
undetectable		 6a4iA-2gmiB:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A4I_B_TRPB403_0
(TRYPTOPHAN
2,3-DIOXYGENASE)		 2gmi UBIQUITIN-CONJUGATIN
G ENZYME VARIANT
MMS2
(Saccharomyces
cerevisiae) 		4 / 7 ARG B 117
THR B 122
PRO B 123
PRO B  84
 None
 1.04A 6a4iB-2gmiB:
undetectable		 6a4iB-2gmiB:
16.37