SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gml'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1WRL_B_TFPB203_1 (TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES)	2gml	RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE F (Escherichia coli)	4 / 6	PHE A 112 VAL A 74 LEU A 138 PHE A 84	None	1.00A	1wrlB-2gmlA: undetectable	1wrlB-2gmlA: 17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1XZX_X_T3X500_1 (THYROID HORMONE RECEPTOR BETA-1)	2gml	RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE F (Escherichia coli)	5 / 12	ILE A 171 ILE A 61 ALA A 64 MET A 144 LEU A 159	None	1.21A	1xzxX-2gmlA: undetectable	1xzxX-2gmlA: 24.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2N27_A_4DYA205_1 (CALMODULIN)	2gml	RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE F (Escherichia coli)	5 / 11	LEU A 116 ILE A 124 LEU A 159 VAL A 146 MET A 144	None	1.32A	2n27A-2gmlA: undetectable	2n27A-2gmlA: 21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM4_A_DR7A100_2 (PROTEASE)	2gml	RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE F (Escherichia coli)	5 / 9	ASP A 42 GLY A 47 LEU A 48 VAL A 29 ILE A 25	None	1.07A	3em4B-2gmlA: undetectable	3em4B-2gmlA: 18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3EM4_V_DR7V100_2 (PROTEASE)	2gml	RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE F (Escherichia coli)	5 / 10	ASP A 42 GLY A 47 LEU A 48 VAL A 29 ILE A 25	None	1.04A	3em4V-2gmlA: undetectable	3em4V-2gmlA: 18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5NFJ_A_SAMA501_0 (MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1)	2gml	RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE F (Escherichia coli)	5 / 12	GLY A 39 LEU A 4 LEU A 2 LEU A 57 LEU A 62	None	0.91A	5nfjA-2gmlA: undetectable	5nfjA-2gmlA: 20.16

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1WRL_B_TFPB203_1","TROPONIN C, SLOW SKELETAL AND CARDIAC MUSCLES","2gml","RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE F","Escherichia coli",4,"PHE A 112;VAL A  74;LEU A 138;PHE A  84","None","1.00A","1wrlB-2gmlA:undetectable","1wrlB-2gmlA:17.65"],["1XZX_X_T3X500_1","THYROID HORMONE RECEPTOR BETA-1","2gml","RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE F","Escherichia coli",5,"ILE A 171;ILE A  61;ALA A  64;MET A 144;LEU A 159","None","1.21A","1xzxX-2gmlA:undetectable","1xzxX-2gmlA:24.57"],["2N27_A_4DYA205_1","CALMODULIN","2gml","RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE F","Escherichia coli",5,"LEU A 116;ILE A 124;LEU A 159;VAL A 146;MET A 144","None","1.32A","2n27A-2gmlA:undetectable","2n27A-2gmlA:21.16"],["3EM4_A_DR7A100_2","PROTEASE;PROTEASE","2gml","RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE F","Escherichia coli",5,"ASP A  42;GLY A  47;LEU A  48;VAL A  29;ILE A  25","None","1.07A","3em4B-2gmlA:undetectable","3em4B-2gmlA:18.49"],["3EM4_V_DR7V100_2","PROTEASE","2gml","RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE F","Escherichia coli",5,"ASP A  42;GLY A  47;LEU A  48;VAL A  29;ILE A  25","None","1.04A","3em4V-2gmlA:undetectable","3em4V-2gmlA:18.49"],["5NFJ_A_SAMA501_0","MITOCHONDRIAL RIBONUCLEASE P PROTEIN 1","2gml","RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE F","Escherichia coli",5,"GLY A  39;LEU A   4;LEU A   2;LEU A  57;LEU A  62","None","0.91A","5nfjA-2gmlA:undetectable","5nfjA-2gmlA:20.16"]]