SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gmn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 12 LEU A 210
HIS A 242
HIS A 101
TYR A 223
ILE A 219
 None
ZN  A 802 (-3.2A)
ZN  A 801 (-3.2A)
None
None
 1.39A 1fmlA-2gmnA:
undetectable		 1fmlA-2gmnA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 12 ILE A 113
ALA A 119
LEU A 164
LEU A  66
ILE A  94
 None
 1.26A 1g5yB-2gmnA:
undetectable		 1g5yB-2gmnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_A_DAHA382_1
(AMINE OXIDASE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 10 TYR A 136
ASP A 222
TYR A 223
HIS A 103
HIS A 101
 None
None
None
ZN  A 801 (-3.1A)
ZN  A 801 (-3.2A)
 1.43A 1ivvA-2gmnA:
undetectable		 1ivvA-2gmnA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IVV_B_DAHB382_1
(AMINE OXIDASE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 10 TYR A 136
ASP A 222
TYR A 223
HIS A 103
HIS A 101
 None
None
None
ZN  A 801 (-3.1A)
ZN  A 801 (-3.2A)
 1.45A 1ivvB-2gmnA:
undetectable		 1ivvB-2gmnA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_2
(ADENOSYLHOMOCYSTEINA
SE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		3 / 3 THR A 168
GLU A 196
HIS A 172
 None
None
ZN  A 805 (-3.1A)
 0.91A 1xwfA-2gmnA:
undetectable		 1xwfA-2gmnA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 6 LEU A  68
VAL A  57
ILE A  80
ILE A 113
 None
 0.79A 2piwA-2gmnA:
undetectable		 2piwA-2gmnA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 7 ILE A  55
TYR A 246
TYR A  58
TYR A  49
 None
 1.36A 2xz5D-2gmnA:
undetectable
2xz5E-2gmnA:
undetectable		 2xz5D-2gmnA:
22.02
2xz5E-2gmnA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GSS_B_EAAB211_1
(GLUTATHIONE
S-TRANSFERASE P1-1)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 7 VAL A 245
ILE A  55
THR A  71
GLY A 240
 None
 0.92A 3gssB-2gmnA:
undetectable		 3gssB-2gmnA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N2O_C_AG2C1002_1
(BIOSYNTHETIC
ARGININE
DECARBOXYLASE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 8 HIS A 242
ASP A 127
LEU A 131
ASP A  70
 ZN  A 802 (-3.2A)
None
None
None
 1.10A 3n2oC-2gmnA:
undetectable
3n2oD-2gmnA:
undetectable		 3n2oC-2gmnA:
19.56
3n2oD-2gmnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROX_A_TEPA266_1
(APOLIPOPROTEIN
A-I-BINDING PROTEIN)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 8 ALA A 111
VAL A 150
LEU A 131
LEU A 104
THR A 107
 None
 1.33A 3roxA-2gmnA:
undetectable		 3roxA-2gmnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RUK_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 12 ILE A  67
LEU A  96
ALA A 171
THR A 182
VAL A 122
 None
 0.97A 3rukA-2gmnA:
undetectable		 3rukA-2gmnA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1D_B_X8ZB350_1
(BETA-LACTAMASE CLASS
B VIM-2)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 10 HIS A 101
HIS A 103
ASP A 105
HIS A 177
HIS A 242
 ZN  A 801 (-3.2A)
ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 801 (-3.2A)
ZN  A 802 (-3.2A)
 0.89A 4c1dB-2gmnA:
18.3		 4c1dB-2gmnA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1F_A_X8ZA300_1
(BETA-LACTAMASE IMP-1)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 11 HIS A 101
HIS A 103
ASP A 105
HIS A 177
HIS A 242
 ZN  A 801 (-3.2A)
ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 801 (-3.2A)
ZN  A 802 (-3.2A)
 0.94A 4c1fA-2gmnA:
18.4
4c1fB-2gmnA:
17.9		 4c1fA-2gmnA:
24.82
4c1fB-2gmnA:
24.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 9 HIS A 101
HIS A 103
ASP A 105
HIS A 177
HIS A 242
 ZN  A 801 (-3.2A)
ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 801 (-3.2A)
ZN  A 802 (-3.2A)
 0.90A 4c1hA-2gmnA:
19.4		 4c1hA-2gmnA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 9 HIS A 103
ASP A 105
HIS A 101
GLY A 203
HIS A 242
 ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 801 (-3.2A)
None
ZN  A 802 (-3.2A)
 0.93A 4c1hA-2gmnA:
19.4		 4c1hA-2gmnA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C1H_A_X8ZA305_1
(BETA-LACTAMASE 2)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 9 TRP A  34
HIS A 103
ASP A 105
HIS A 101
GLY A 203
 None
ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 801 (-3.2A)
None
 1.18A 4c1hA-2gmnA:
19.4		 4c1hA-2gmnA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 8 HIS A 103
ASP A 105
HIS A 101
HIS A 242
 ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 801 (-3.2A)
ZN  A 802 (-3.2A)
 0.85A 4exsB-2gmnA:
17.5		 4exsB-2gmnA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EXS_B_X8ZB301_1
(BETA-LACTAMASE NDM-1)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 8 HIS A 103
ASP A 105
HIS A 177
HIS A 242
 ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 801 (-3.2A)
ZN  A 802 (-3.2A)
 0.81A 4exsB-2gmnA:
17.5		 4exsB-2gmnA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K0B_B_SAMB504_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 8 HIS A 242
PRO A 241
ALA A 206
SER A 202
 ZN  A 802 (-3.2A)
None
None
None
 1.05A 4k0bB-2gmnA:
undetectable		 4k0bB-2gmnA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L7I_B_SAMB501_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 8 HIS A 242
PRO A 241
ALA A 206
SER A 202
 ZN  A 802 (-3.2A)
None
None
None
 1.07A 4l7iB-2gmnA:
undetectable		 4l7iB-2gmnA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_D_ACTD201_0
(RETINOL-BINDING
PROTEIN 2)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		3 / 3 ASP A 105
HIS A 242
LYS A  29
 ZN  A 802 (-2.5A)
ZN  A 802 (-3.2A)
None
 0.89A 4qzuD-2gmnA:
undetectable		 4qzuD-2gmnA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTB_A_SAMA501_0
(HYDG PROTEIN)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 12 VAL A 188
LEU A 198
PHE A 199
LEU A  98
LEU A  96
 None
 1.15A 4rtbA-2gmnA:
undetectable		 4rtbA-2gmnA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 10 GLY A  51
VAL A  50
THR A  77
VAL A  57
LEU A  68
 None
 1.20A 4yb6B-2gmnA:
undetectable
4yb6C-2gmnA:
undetectable		 4yb6B-2gmnA:
23.48
4yb6C-2gmnA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 10 LEU A  68
GLY A  51
VAL A  50
THR A  77
VAL A  57
 None
 1.27A 4yb6D-2gmnA:
undetectable
4yb6E-2gmnA:
undetectable		 4yb6D-2gmnA:
23.48
4yb6E-2gmnA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		5 / 10 LEU A  68
GLY A  51
VAL A  50
THR A  77
VAL A  57
 None
 1.22A 4yb6B-2gmnA:
undetectable
4yb6F-2gmnA:
undetectable		 4yb6B-2gmnA:
23.48
4yb6F-2gmnA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 8 HIS A 103
ASP A 105
HIS A 101
HIS A 242
 ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 801 (-3.2A)
ZN  A 802 (-3.2A)
 0.91A 5a5zA-2gmnA:
17.5		 5a5zA-2gmnA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A5Z_A_WJZA304_0
(BETA-LACTAMASE NDM-1)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 8 HIS A 103
ASP A 105
HIS A 177
HIS A 242
 ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 801 (-3.2A)
ZN  A 802 (-3.2A)
 0.83A 5a5zA-2gmnA:
17.5		 5a5zA-2gmnA:
26.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		8 / 11 HIS A 101
HIS A 103
ASP A 105
HIS A 106
HIS A 177
THR A 204
HIS A 242
GLU A 244
 ZN  A 801 (-3.2A)
ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 802 (-3.2A)
ZN  A 801 (-3.2A)
None
ZN  A 802 (-3.2A)
None
 0.40A 5ayaA-2gmnA:
34.6		 5ayaA-2gmnA:
31.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		8 / 11 HIS A 101
HIS A 103
ASP A 105
HIS A 177
SER A 202
THR A 204
HIS A 242
GLU A 244
 ZN  A 801 (-3.2A)
ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 801 (-3.2A)
None
None
ZN  A 802 (-3.2A)
None
 0.71A 5ayaA-2gmnA:
34.6		 5ayaA-2gmnA:
31.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMF_A_6U9A1301_1
(ION TRANSPORT
PROTEIN)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 6 THR A  77
GLY A 109
GLU A 112
PHE A 110
 None
 0.92A 5kmfA-2gmnA:
undetectable
5kmfC-2gmnA:
undetectable		 5kmfA-2gmnA:
23.51
5kmfC-2gmnA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 8 HIS A 103
ASP A 105
HIS A 101
HIS A 242
 ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 801 (-3.2A)
ZN  A 802 (-3.2A)
 0.80A 5zj8A-2gmnA:
16.8		 5zj8A-2gmnA:
26.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJ8_A_9DCA303_0
(METALLO-BETA-LACTAMA
SE TYPE 2)		 2gmn METALLO-BETA-LACTAMA
SE
(Bradyrhizobium
diazoefficiens) 		4 / 8 HIS A 103
ASP A 105
HIS A 177
HIS A 242
 ZN  A 801 (-3.1A)
ZN  A 802 (-2.5A)
ZN  A 801 (-3.2A)
ZN  A 802 (-3.2A)
 0.88A 5zj8A-2gmnA:
16.8		 5zj8A-2gmnA:
26.91