SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gmu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_2
(HIV-II PROTEASE)		 2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK
(Escherichia
coli) 		5 / 8 ASP A 106
ALA A  85
GLY A 336
ILE A 109
ILE A 107
 None
 1.18A 1hshD-2gmuA:
undetectable		 1hshD-2gmuA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK
(Escherichia
coli) 		4 / 5 LEU A  61
VAL A 249
TYR A 247
THR A  58
 None
 1.30A 1nw3A-2gmuA:
2.5		 1nw3A-2gmuA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_C_KLNC1499_1
(CYTOCHROME P450 3A4)		 2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK
(Escherichia
coli) 		4 / 7 LEU A 263
PHE A  45
ILE A 270
GLY A 259
 None
 0.92A 2v0mC-2gmuA:
undetectable		 2v0mC-2gmuA:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_A_LYAA514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK
(Escherichia
coli) 		5 / 12 THR A 335
ILE A 333
SER A 305
LEU A 136
TYR A  92
 None
 0.94A 3k2hA-2gmuA:
undetectable		 3k2hA-2gmuA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_2
(PROTEIN S100-A4)		 2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK
(Escherichia
coli) 		3 / 3 GLU A 278
LEU A 281
ASP A 282
 None
 0.37A 3ko0T-2gmuA:
undetectable		 3ko0T-2gmuA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3003_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK
(Escherichia
coli) 		4 / 6 ILE A 328
VAL A 369
LEU A 367
LEU A 319
 None
 0.87A 3kp6A-2gmuA:
undetectable
3kp6B-2gmuA:
undetectable		 3kp6A-2gmuA:
18.18
3kp6B-2gmuA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK
(Escherichia
coli) 		4 / 5 TYR A 206
ILE A 205
ASN A 225
ILE A 208
 None
 1.02A 4jtpA-2gmuA:
undetectable		 4jtpA-2gmuA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK
(Escherichia
coli) 		4 / 4 GLY A 195
ALA A 191
MET A 164
THR A  10
 None
 1.29A 5n0sB-2gmuA:
undetectable		 5n0sB-2gmuA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUD_A_ERMA2001_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2B,SOLUBLE
CYTOCHROME B562
CHIMERA)		 2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK
(Escherichia
coli) 		4 / 7 THR A 181
LEU A 135
ASN A 140
GLU A 295
 None
 0.96A 5tudA-2gmuA:
undetectable		 5tudA-2gmuA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FI4_B_DVAB8_0
(14-3-3 PROTEIN SIGMA
PRO-SEP-LEU-PRO-DVA)		 2gmu PUTATIVE
PYRIDOXAMINE
5-PHOSPHATE-DEPENDEN
T DEHYDRASE, WBDK
(Escherichia
coli) 		4 / 5 SER A 271
VAL A 272
LYS A 275
ASN A 276
 None
 0.96A 6fi4A-2gmuA:
undetectable
6fi4B-2gmuA:
undetectable		 6fi4A-2gmuA:
19.00
6fi4B-2gmuA:
60.00