SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gn4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		4 / 6 ARG A 258
ASP A 132
ASP A 149
GLU A 261
 UD1  A 335 (-3.0A)
UD1  A 335 (-2.6A)
None
UD1  A 335 (-2.7A)
 1.24A 1rjdC-2gn4A:
6.4		 1rjdC-2gn4A:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CWK_A_REAA300_1
(CELLULAR RETINOIC
ACID-BINDING PROTEIN
2)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 12 LEU A  90
ALA A  89
ALA A  87
VAL A  41
VAL A  68
 None
NDP  A 334 (-3.2A)
NDP  A 334 (-4.1A)
None
NDP  A 334 (-3.5A)
 1.19A 3cwkA-2gn4A:
undetectable		 3cwkA-2gn4A:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZ0_B_CLYB900_1
(LINCOSAMIDE
NUCLEOTIDYLTRANSFERA
SE)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		4 / 8 GLU A  51
PHE A  63
SER A  43
ILE A  65
 None
None
NDP  A 334 (-3.8A)
None
 1.08A 3jz0B-2gn4A:
undetectable		 3jz0B-2gn4A:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OGQ_A_AB1A200_2
(FIV PROTEASE)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 12 ARG A  73
GLY A  80
ASP A  82
ILE A  83
LEU A  14
 None
 0.92A 3ogqB-2gn4A:
undetectable		 3ogqB-2gn4A:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AF0_A_MOAA1526_1
(INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		4 / 8 SER A 316
SER A 317
ASN A 320
GLY A 172
 None
None
None
UD1  A 335 ( 4.0A)
 0.87A 4af0A-2gn4A:
undetectable		 4af0A-2gn4A:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AWU_A_4CHA502_0
(OXIDOREDUCTASE,
FMN-BINDING)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		4 / 7 THR A 164
ASN A 121
LEU A  78
PHE A 166
 None
 1.34A 4awuA-2gn4A:
undetectable		 4awuA-2gn4A:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 12 ASN A 107
SER A 148
LEU A 151
ILE A 115
CYH A 118
 None
 1.30A 4k36A-2gn4A:
undetectable		 4k36A-2gn4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 12 MET A 237
LEU A 324
VAL A 182
LEU A 242
LEU A 332
 None
 1.34A 4m11A-2gn4A:
undetectable		 4m11A-2gn4A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 8 ILE A 284
GLU A 228
LEU A 218
LEU A 302
PHE A 279
 None
 1.37A 4r38B-2gn4A:
undetectable		 4r38B-2gn4A:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 10 GLY A 176
VAL A 175
VAL A 182
MET A 239
LEU A 242
 None
None
None
UD1  A 335 (-3.2A)
None
 1.17A 4yb6A-2gn4A:
undetectable
4yb6E-2gn4A:
undetectable		 4yb6A-2gn4A:
23.45
4yb6E-2gn4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 10 GLY A 176
VAL A 175
VAL A 182
MET A 239
LEU A 242
 None
None
None
UD1  A 335 (-3.2A)
None
 1.16A 4yb6B-2gn4A:
1.3
4yb6C-2gn4A:
undetectable		 4yb6B-2gn4A:
23.45
4yb6C-2gn4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 10 GLY A 176
VAL A 175
VAL A 182
MET A 239
LEU A 242
 None
None
None
UD1  A 335 (-3.2A)
None
 1.23A 4yb6C-2gn4A:
undetectable
4yb6F-2gn4A:
undetectable		 4yb6C-2gn4A:
23.45
4yb6F-2gn4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 10 MET A 239
LEU A 242
GLY A 176
VAL A 175
VAL A 182
 UD1  A 335 (-3.2A)
None
None
None
None
 1.22A 4yb6A-2gn4A:
undetectable
4yb6D-2gn4A:
undetectable		 4yb6A-2gn4A:
23.45
4yb6D-2gn4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 10 MET A 239
LEU A 242
GLY A 176
VAL A 175
VAL A 182
 UD1  A 335 (-3.2A)
None
None
None
None
 1.23A 4yb6D-2gn4A:
undetectable
4yb6E-2gn4A:
undetectable		 4yb6D-2gn4A:
23.45
4yb6E-2gn4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 10 MET A 239
LEU A 242
GLY A 176
VAL A 175
VAL A 182
 UD1  A 335 (-3.2A)
None
None
None
None
 1.15A 4yb6B-2gn4A:
undetectable
4yb6F-2gn4A:
undetectable		 4yb6B-2gn4A:
23.45
4yb6F-2gn4A:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE1_A_X2NA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 12 GLY A 110
MET A 109
GLY A 172
LEU A 129
HIS A  86
 None
None
UD1  A 335 ( 4.0A)
NDP  A 334 (-3.8A)
None
 1.23A 4ze1A-2gn4A:
undetectable		 4ze1A-2gn4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 2gn4 UDP-GLCNAC C6
DEHYDRATASE
(Helicobacter
pylori) 		5 / 9 VAL A  93
HIS A  92
LEU A 146
ALA A 134
ASP A 132
 UD1  A 335 ( 4.9A)
UD1  A 335 (-3.7A)
None
None
UD1  A 335 (-2.6A)
 1.36A 6c2mB-2gn4A:
undetectable		 6c2mB-2gn4A:
11.05