SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gno'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 8 LEU A  45
TYR A  92
ILE A  28
ARG A  90
ILE A  19
 None
 1.17A 2bu8A-2gnoA:
undetectable		 2bu8A-2gnoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 8 LEU A  45
TYR A  92
ILE A  28
ILE A  20
ILE A  19
 None
 1.46A 2bu8A-2gnoA:
undetectable		 2bu8A-2gnoA:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OCU_A_TYLA3001_1
(LACTOTRANSFERRIN)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		3 / 3 LEU A 154
TYR A 180
GLY A 183
 None
 0.64A 2ocuA-2gnoA:
undetectable		 2ocuA-2gnoA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 6 LEU A  16
ILE A  28
ILE A  74
LEU A  60
 None
 0.91A 2xkwB-2gnoA:
undetectable		 2xkwB-2gnoA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 4 VAL A 239
ARG A 302
ILE A 259
THR A 199
 None
 1.11A 3cl9A-2gnoA:
undetectable		 3cl9A-2gnoA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_4
(HIV-1 PROTEASE)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 4 ARG A  75
ASP A  63
GLY A  66
THR A 102
 None
 1.47A 3k4vB-2gnoA:
undetectable		 3k4vB-2gnoA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_B_TFPB202_2
(PROTEIN S100-A4)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 6 LEU A 277
SER A 275
PHE A 276
ILE A 300
 None
 0.90A 3ko0B-2gnoA:
2.1		 3ko0B-2gnoA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 6 LEU A 277
SER A 275
PHE A 276
ILE A 300
 None
 0.82A 3ko0S-2gnoA:
2.0		 3ko0S-2gnoA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 9 PRO A  46
ILE A  94
VAL A 121
ILE A  30
ILE A  28
 None
 1.23A 3p4wB-2gnoA:
undetectable		 3p4wB-2gnoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_D_DSFD319_1
(GLR4197 PROTEIN)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 10 PRO A  46
ILE A  94
VAL A 121
ILE A  30
ILE A  28
 None
 1.22A 3p4wD-2gnoA:
undetectable		 3p4wD-2gnoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_E_DSFE319_1
(GLR4197 PROTEIN)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 10 PRO A  46
ILE A  94
VAL A 121
ILE A  30
ILE A  28
 None
 1.23A 3p4wE-2gnoA:
undetectable		 3p4wE-2gnoA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		5 / 12 LEU A 202
VAL A 206
THR A 256
ILE A 280
VAL A 239
 None
 1.15A 3sp9B-2gnoA:
undetectable		 3sp9B-2gnoA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MGH_A_ACTA1320_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 5 VAL A 143
LEU A  16
ILE A  28
LEU A  29
 None
 0.85A 4mghA-2gnoA:
undetectable		 4mghA-2gnoA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		3 / 3 ASP A 278
ARG A 127
ARG A 171
 None
 0.99A 4x5iA-2gnoA:
undetectable		 4x5iA-2gnoA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_C_29SC601_2
(ESTROGEN RECEPTOR)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		4 / 6 LEU A 220
GLU A 222
ILE A 297
PRO A 167
 None
 1.04A 4xi3C-2gnoA:
undetectable		 4xi3C-2gnoA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA617_0
(SERUM ALBUMIN)		 2gno DNA POLYMERASE III,
GAMMA
SUBUNIT-RELATED
PROTEIN
(Thermotoga
maritima) 		3 / 3 TRP A 163
ARG A 152
LEU A 154
 None
 0.98A 5dbyA-2gnoA:
undetectable		 5dbyA-2gnoA:
20.48