SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gnp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 8 SER A  76
GLU A  65
ILE A  79
ASP A  58
 None
 0.93A 1jg4A-2gnpA:
undetectable		 1jg4A-2gnpA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V55_P_CHDP4271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE III
CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 7 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 1.03A 1v55P-2gnpA:
undetectable
1v55W-2gnpA:
undetectable		 1v55P-2gnpA:
19.19
1v55W-2gnpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DYS_P_CHDP310_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 7 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 0.95A 2dysP-2gnpA:
undetectable
2dysW-2gnpA:
undetectable		 2dysP-2gnpA:
19.19
2dysW-2gnpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIJ_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 7 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 0.92A 2eijP-2gnpA:
undetectable
2eijW-2gnpA:
undetectable		 2eijP-2gnpA:
19.19
2eijW-2gnpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 8 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 0.86A 2eilP-2gnpA:
undetectable
2eilW-2gnpA:
undetectable		 2eilP-2gnpA:
19.19
2eilW-2gnpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HYY_A_STIA600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 6 LEU A  77
VAL A 239
VAL A 311
ILE A 210
 None
 0.91A 2hyyA-2gnpA:
undetectable		 2hyyA-2gnpA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_B_D16B409_1
(THYMIDYLATE SYNTHASE)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 8 ARG A 104
ILE A 107
GLY A 114
PHE A 138
 None
 0.87A 2tsrB-2gnpA:
undetectable		 2tsrB-2gnpA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_A_ASDA1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 8 ILE A 210
GLY A 209
LEU A 121
LEU A 124
 None
 0.78A 2vctA-2gnpA:
undetectable		 2vctA-2gnpA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_B_ASDB1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 8 ILE A 210
GLY A 209
LEU A 121
LEU A 124
 None
 0.78A 2vctB-2gnpA:
undetectable		 2vctB-2gnpA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VCT_C_ASDC1223_1
(GLUTATHIONE
S-TRANSFERASE A2)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 8 ILE A 210
GLY A 209
LEU A 121
LEU A 124
 None
 0.77A 2vctC-2gnpA:
undetectable		 2vctC-2gnpA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_0
(WNT INHIBITORY
FACTOR 1)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 ILE A 113
ILE A 205
ILE A 128
MET A 161
PHE A 115
 None
 1.01A 2ygnA-2gnpA:
undetectable		 2ygnA-2gnpA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG2_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 7 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 0.72A 3ag2P-2gnpA:
undetectable
3ag2W-2gnpA:
undetectable		 3ag2P-2gnpA:
19.19
3ag2W-2gnpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 4 LEU A 293
ASP A 317
VAL A 286
THR A 307
 None
 1.22A 3cyxB-2gnpA:
undetectable		 3cyxB-2gnpA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_1
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		5 / 10 VAL A 311
ILE A  95
LEU A  77
VAL A  68
LEU A 293
 None
 0.99A 3gwxA-2gnpA:
undetectable		 3gwxA-2gnpA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S56_B_ROCB203_1
(PROTEASE)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		5 / 7 LEU A 267
GLU A 253
LEU A 297
GLU A 241
ILE A 242
 None
 1.46A 3s56B-2gnpA:
undetectable		 3s56B-2gnpA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SP9_B_IL2B901_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR DELTA)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 LEU A 157
VAL A 125
ILE A  80
LEU A 277
VAL A 207
 None
 1.18A 3sp9B-2gnpA:
undetectable		 3sp9B-2gnpA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 7 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 0.88A 3x2qC-2gnpA:
undetectable
3x2qJ-2gnpA:
undetectable		 3x2qC-2gnpA:
19.19
3x2qJ-2gnpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 7 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 0.73A 3x2qP-2gnpA:
undetectable
3x2qW-2gnpA:
undetectable		 3x2qP-2gnpA:
19.19
3x2qW-2gnpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_E_ZPCE1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 6 GLU A 160
PHE A 115
HIS A 129
VAL A 133
 None
 1.19A 4a97E-2gnpA:
undetectable		 4a97E-2gnpA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DM8_A_REAA501_1
(RETINOIC ACID
RECEPTOR BETA)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		5 / 11 LEU A 312
LEU A 309
LEU A 290
LEU A 301
ILE A  79
 PEG  A 319 ( 4.7A)
None
None
None
None
 1.17A 4dm8A-2gnpA:
undetectable		 4dm8A-2gnpA:
24.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 8 VAL A 208
LEU A 141
ASP A 204
ILE A 205
 None
 0.86A 4lzrA-2gnpA:
undetectable		 4lzrA-2gnpA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_1
(BETA-LACTOGLOBULIN)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		3 / 3 LYS A 310
ILE A 308
ILE A  79
 None
 0.66A 4y0qA-2gnpA:
undetectable		 4y0qA-2gnpA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 7 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 0.85A 5b1aP-2gnpA:
undetectable
5b1aW-2gnpA:
undetectable		 5b1aP-2gnpA:
19.19
5b1aW-2gnpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 7 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 0.73A 5b3sC-2gnpA:
undetectable
5b3sJ-2gnpA:
undetectable		 5b3sC-2gnpA:
19.19
5b3sJ-2gnpA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 6 LYS A 310
ASP A 315
TYR A  67
LEU A  64
 None
None
PEG  A 319 ( 3.8A)
PEG  A 319 ( 4.9A)
 1.21A 5bmvB-2gnpA:
undetectable		 5bmvB-2gnpA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 PHE A 138
ILE A 107
LEU A 124
VAL A 125
PHE A 165
 None
 1.17A 5im2A-2gnpA:
undetectable		 5im2A-2gnpA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 7 LEU A 258
GLN A 259
LEU A 225
PHE A 230
 None
 0.92A 5iy5C-2gnpA:
undetectable
5iy5J-2gnpA:
undetectable		 5iy5C-2gnpA:
19.19
5iy5J-2gnpA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		4 / 8 ALA A 264
ILE A 187
ALA A 184
LEU A 188
 None
 0.82A 5te8B-2gnpA:
undetectable		 5te8B-2gnpA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_E_C2FE3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 GLY A 282
VAL A 298
LEU A 277
GLY A 209
ILE A 210
 None
 1.17A 5vooE-2gnpA:
undetectable		 5vooE-2gnpA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		5 / 12 GLY A 282
VAL A 298
LEU A 277
GLY A 209
ILE A 210
 None
 1.19A 5vooF-2gnpA:
undetectable		 5vooF-2gnpA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2gnp TRANSCRIPTIONAL
REGULATOR
(Streptococcus
pneumoniae) 		3 / 3 TYR A 281
ASN A  82
LEU A  91
 None
 0.83A 6b58A-2gnpA:
0.0		 6b58A-2gnpA:
18.58