SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gnw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1868_0
(FPRA)		 2gnw NON-SYMBIOTIC
HEMOGLOBIN 1
(Oryza
sativa) 		3 / 3 ALA A 116
HIS A 117
VAL A 120
 None
HEM  A 166 (-4.8A)
None
 0.48A 1lqtB-2gnwA:
undetectable		 1lqtB-2gnwA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQU_B_ACTB1425_0
(FPRA)		 2gnw NON-SYMBIOTIC
HEMOGLOBIN 1
(Oryza
sativa) 		3 / 3 ALA A 116
HIS A 117
VAL A 120
 None
HEM  A 166 (-4.8A)
None
 0.50A 1lquB-2gnwA:
undetectable		 1lquB-2gnwA:
16.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JST_A_HLTA101_1
(FOUR-ALPHA-HELIX
BUNDLE)		 2gnw NON-SYMBIOTIC
HEMOGLOBIN 1
(Oryza
sativa) 		4 / 5 ALA A  74
TRP A  40
LEU A  64
ALA A  36
 None
 1.15A 2jstA-2gnwA:
1.6
2jstB-2gnwA:
1.6		 2jstA-2gnwA:
18.79
2jstB-2gnwA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2KOT_B_ANWB99_0
(PROTEIN S100-A13)		 2gnw NON-SYMBIOTIC
HEMOGLOBIN 1
(Oryza
sativa) 		4 / 8 ALA A  36
THR A 128
LYS A  29
ASP A  31
 None
 1.16A 2kotB-2gnwA:
undetectable		 2kotB-2gnwA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2gnw NON-SYMBIOTIC
HEMOGLOBIN 1
(Oryza
sativa) 		5 / 12 GLN A  87
LEU A 101
ALA A 156
VAL A 154
LEU A 126
 None
None
None
HEM  A 166 (-4.4A)
None
 1.29A 3b0wB-2gnwA:
undetectable		 3b0wB-2gnwA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC150_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2gnw NON-SYMBIOTIC
HEMOGLOBIN 1
(Oryza
sativa) 		5 / 12 PHE A  54
VAL A 121
LEU A 125
ILE A  43
THR A 128
 HEM  A 166 (-3.9A)
HEM  A 166 (-4.4A)
None
None
None
 1.44A 3elzC-2gnwA:
undetectable		 3elzC-2gnwA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_A_IPHA101_0
(INSULIN)		 2gnw NON-SYMBIOTIC
HEMOGLOBIN 1
(Oryza
sativa) 		5 / 10 LEU A 101
HIS A 152
LEU A 153
ALA A 156
LEU A  88
 None
None
HEM  A 166 ( 4.7A)
None
None
 1.10A 4p65A-2gnwA:
undetectable
4p65B-2gnwA:
undetectable
4p65F-2gnwA:
undetectable
4p65H-2gnwA:
undetectable		 4p65A-2gnwA:
5.45
4p65B-2gnwA:
9.70
4p65F-2gnwA:
9.70
4p65H-2gnwA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_C_IPHC101_0
(INSULIN)		 2gnw NON-SYMBIOTIC
HEMOGLOBIN 1
(Oryza
sativa) 		5 / 11 LEU A 101
HIS A 152
LEU A 153
ALA A 156
LEU A  88
 None
None
HEM  A 166 ( 4.7A)
None
None
 1.08A 4p65C-2gnwA:
undetectable
4p65D-2gnwA:
undetectable
4p65J-2gnwA:
undetectable
4p65L-2gnwA:
undetectable		 4p65C-2gnwA:
5.45
4p65D-2gnwA:
9.70
4p65J-2gnwA:
9.70
4p65L-2gnwA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_E_IPHE101_0
(INSULIN)		 2gnw NON-SYMBIOTIC
HEMOGLOBIN 1
(Oryza
sativa) 		5 / 11 LEU A 101
HIS A 152
LEU A 153
ALA A 156
LEU A  88
 None
None
HEM  A 166 ( 4.7A)
None
None
 1.08A 4p65E-2gnwA:
undetectable
4p65F-2gnwA:
undetectable
4p65J-2gnwA:
undetectable
4p65L-2gnwA:
undetectable		 4p65E-2gnwA:
5.45
4p65F-2gnwA:
9.70
4p65J-2gnwA:
9.70
4p65L-2gnwA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P65_G_IPHG101_0
(INSULIN)		 2gnw NON-SYMBIOTIC
HEMOGLOBIN 1
(Oryza
sativa) 		5 / 11 LEU A  88
LEU A 101
HIS A 152
LEU A 153
ALA A 156
 None
None
None
HEM  A 166 ( 4.7A)
None
 1.13A 4p65B-2gnwA:
undetectable
4p65D-2gnwA:
undetectable
4p65G-2gnwA:
undetectable
4p65H-2gnwA:
undetectable		 4p65B-2gnwA:
9.70
4p65D-2gnwA:
9.70
4p65G-2gnwA:
5.45
4p65H-2gnwA:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X20_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2gnw NON-SYMBIOTIC
HEMOGLOBIN 1
(Oryza
sativa) 		3 / 3 SER A  12
ALA A  10
VAL A   9
 None
 0.63A 4x20C-2gnwA:
undetectable		 4x20C-2gnwA:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M24_A_9CRA501_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2gnw NON-SYMBIOTIC
HEMOGLOBIN 1
(Oryza
sativa) 		5 / 12 TRP A  40
PHE A  39
ALA A 124
ILE A 129
PHE A  78
 None
 1.07A 5m24A-2gnwA:
undetectable		 5m24A-2gnwA:
21.91