SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gnx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2gnx HYPOTHETICAL PROTEIN
(Mus
musculus) 		3 / 3 THR A 403
LEU A 395
VAL A 382
 None
 0.65A 1mz9E-2gnxA:
undetectable		 1mz9E-2gnxA:
8.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA702_0
(FERROCHELATASE)		 2gnx HYPOTHETICAL PROTEIN
(Mus
musculus) 		4 / 7 ARG A 371
LEU A 375
PRO A 357
VAL A 405
 None
 1.19A 2hrcA-2gnxA:
undetectable		 2hrcA-2gnxA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_NIMA300_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2gnx HYPOTHETICAL PROTEIN
(Mus
musculus) 		4 / 5 LEU A 266
ALA A 200
ILE A 204
SER A 212
 None
 0.92A 2othA-2gnxA:
undetectable		 2othA-2gnxA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 2gnx HYPOTHETICAL PROTEIN
(Mus
musculus) 		4 / 5 PHE A 422
PHE A 304
PHE A 394
PHE A 408
 None
 1.45A 3ko0F-2gnxA:
undetectable
3ko0G-2gnxA:
undetectable		 3ko0F-2gnxA:
17.15
3ko0G-2gnxA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 2gnx HYPOTHETICAL PROTEIN
(Mus
musculus) 		5 / 9 ILE A 404
LEU A 426
LYS A 412
ILE A 420
PHE A 422
 None
 1.27A 3sj4X-2gnxA:
undetectable		 3sj4X-2gnxA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PSY_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2gnx HYPOTHETICAL PROTEIN
(Mus
musculus) 		5 / 12 ALA A 200
LEU A 266
ALA A 267
PHE A 269
LEU A 277
 None
 1.02A 4psyA-2gnxA:
undetectable		 4psyA-2gnxA:
16.72