SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2go4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1501_0
(FERROCHELATASE)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A  62
PHE A  39
LEU A 249
HIS A 265
LEU A 243
 None
None
None
TUX  A 901 (-4.1A)
None
 1.17A 1hrkA-2go4A:
undetectable		 1hrkA-2go4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		4 / 7 VAL A  96
ILE A  94
GLU A  78
LEU A 249
 None
None
TUX  A 901 (-3.6A)
None
 0.95A 1j96B-2go4A:
undetectable		 1j96B-2go4A:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_B_CTXB1283_1
(CES1 PROTEIN)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		4 / 7 PRO A 235
LEU A 229
GLY A 228
LEU A 218
 None
 0.93A 1ya4B-2go4A:
undetectable		 1ya4B-2go4A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_A_PNXA1435_1
(CHITINASE)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		4 / 6 GLY A 263
PHE A 261
SER A 260
ARG A 143
 None
 1.25A 2a3cA-2go4A:
undetectable		 2a3cA-2go4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3C_B_PNXB2434_1
(CHITINASE)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		4 / 6 GLY A 263
PHE A 261
SER A 260
ARG A 143
 None
 1.28A 2a3cB-2go4A:
undetectable		 2a3cB-2go4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 VAL A 138
LEU A 271
VAL A 272
THR A  60
GLY A 263
 None
 1.11A 2cbrA-2go4A:
undetectable		 2cbrA-2go4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD3_A_CHDA501_0
(FERROCHELATASE)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		6 / 11 LEU A 250
LEU A 247
LEU A 243
LYS A 278
THR A 156
VAL A 138
 None
 1.46A 2qd3A-2go4A:
undetectable		 2qd3A-2go4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1359_1
(PROSTAGLANDIN
REDUCTASE 2)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		4 / 6 THR A  93
GLU A  95
LYS A  25
ILE A  74
 None
 1.38A 2w98B-2go4A:
undetectable		 2w98B-2go4A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_0
(UNCHARACTERIZED
PROTEIN MJ0883)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 TYR A  23
GLY A  17
ILE A  74
ASN A  99
LEU A  26
 None
 1.23A 2zzmA-2go4A:
undetectable		 2zzmA-2go4A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_C_SAMC302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 247
VAL A  77
LEU A  81
ILE A 145
LEU A 275
 None
 0.93A 3cjtC-2go4A:
undetectable		 3cjtC-2go4A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CJT_O_SAMO302_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 247
VAL A  77
LEU A  81
ILE A 145
LEU A 275
 None
 0.92A 3cjtO-2go4A:
undetectable		 3cjtO-2go4A:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 10 ILE A  94
ILE A  80
VAL A  83
GLY A 245
LEU A  62
 None
 1.28A 3elzC-2go4A:
undetectable		 3elzC-2go4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_0
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 GLU A  22
GLY A  21
ASN A  99
GLY A  17
ASN A 214
 None
 1.25A 3ps9A-2go4A:
undetectable		 3ps9A-2go4A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TI1_A_B49A299_1
(CYCLIN-DEPENDENT
KINASE 2)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 9 ILE A 145
ALA A 147
VAL A 254
ASP A 246
LEU A 247
 None
 1.31A 3ti1A-2go4A:
undetectable		 3ti1A-2go4A:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		4 / 8 ILE A  28
ILE A  80
GLU A 113
LEU A  87
 None
 0.86A 3ua5A-2go4A:
undetectable		 3ua5A-2go4A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 10 ILE A  80
GLY A 108
ASP A 105
GLU A 110
GLY A 106
 None
 1.17A 4bwlC-2go4A:
undetectable		 4bwlC-2go4A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 250
LEU A 247
LEU A 243
THR A 156
VAL A 138
 None
 0.89A 4f4dA-2go4A:
undetectable		 4f4dA-2go4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 250
LEU A 247
LEU A 243
THR A 156
VAL A 138
 None
 0.98A 4f4dB-2go4A:
undetectable		 4f4dB-2go4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		4 / 7 ALA A 147
PRO A 135
LEU A 275
LEU A 271
 None
 0.90A 4iomA-2go4A:
undetectable		 4iomA-2go4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		4 / 8 ALA A 147
PRO A 135
LEU A 275
LEU A 271
 None
 0.90A 4jjkA-2go4A:
undetectable		 4jjkA-2go4A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KLA_A_CHDA502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		4 / 8 LEU A 250
LEU A 247
LEU A 243
VAL A 138
 None
 0.84A 4klaA-2go4A:
undetectable		 4klaA-2go4A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_1
(ADENOSINE KINASE)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 206
GLY A 264
ASN A 268
GLY A 245
ASP A 246
 None
 1.01A 4n09B-2go4A:
undetectable		 4n09B-2go4A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RVG_A_SAMA503_0
(D-MYCAROSE
3-C-METHYLTRANSFERAS
E)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 THR A  60
ILE A 244
GLY A 245
HIS A 238
ILE A 186
 None
None
None
ZN  A 601 ( 3.2A)
None
 0.99A 4rvgA-2go4A:
undetectable		 4rvgA-2go4A:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 ILE A  18
GLY A 210
ASP A 242
HIS A  79
ARG A 190
 TUX  A 901 ( 4.9A)
TUX  A 901 ( 3.9A)
ZN  A 601 ( 2.2A)
ZN  A 601 ( 3.3A)
None
 1.12A 5igvA-2go4A:
undetectable		 5igvA-2go4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 ILE A  18
GLY A 210
ASP A 242
HIS A  79
ARG A 190
 TUX  A 901 ( 4.9A)
TUX  A 901 ( 3.9A)
ZN  A 601 ( 2.2A)
ZN  A 601 ( 3.3A)
None
 1.19A 5igwA-2go4A:
undetectable		 5igwA-2go4A:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_I_Z80I401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		4 / 9 ILE A 201
THR A 191
ASN A 214
ILE A  18
 TUX  A 901 (-4.7A)
TUX  A 901 (-2.9A)
None
TUX  A 901 ( 4.9A)
 0.98A 5lg3I-2go4A:
undetectable		 5lg3I-2go4A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 229
PHE A 167
PHE A 194
ALA A 193
GLY A 159
 None
None
None
TUX  A 901 ( 3.9A)
None
 1.00A 5veuA-2go4A:
undetectable		 5veuA-2go4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_B_RITB602_1
(CYTOCHROME P450 3A5)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 229
PHE A 167
PHE A 194
ALA A 193
GLY A 159
 None
None
None
TUX  A 901 ( 3.9A)
None
 1.01A 5veuB-2go4A:
undetectable		 5veuB-2go4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		5 / 12 LEU A 229
PHE A 167
PHE A 194
ALA A 193
GLY A 159
 None
None
None
TUX  A 901 ( 3.9A)
None
 1.00A 5veuH-2go4A:
undetectable		 5veuH-2go4A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		4 / 4 ASP A  61
ILE A  46
PRO A  47
LEU A  62
 None
 1.43A 6mkeB-2go4A:
undetectable		 6mkeB-2go4A:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2go4 UDP-3-O-[3-HYDROXYMY
RISTOYL]
N-ACETYLGLUCOSAMINE
DEACETYLASE
(Aquifex
aeolicus) 		4 / 4 ASP A  61
ILE A  46
PRO A  47
LEU A  62
 None
 1.39A 6mkeA-2go4A:
undetectable		 6mkeA-2go4A:
12.73