SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2go7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I18_A_RBFA98_1
(RIBOFLAVIN SYNTHASE
ALPHA CHAIN)		 2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 10 LEU A  14
LEU A  93
ILE A 101
PHE A 182
ILE A 180
 None
 1.40A 1i18A-2go7A:
undetectable
1i18B-2go7A:
undetectable		 1i18A-2go7A:
21.36
1i18B-2go7A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6K_A_ADNA699_1
(CHLORINASE)		 2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 7 PHE A 126
TYR A 161
TYR A 106
THR A 107
 None
None
CL  A 210 ( 4.3A)
CL  A 212 (-4.1A)
 1.44A 2q6kA-2go7A:
2.1		 2q6kA-2go7A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA502_0
(CHORISMATE SYNTHASE)		 2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		3 / 3 GLY A 163
ASP A 168
SER A 179
 None
MG  A 207 ( 4.5A)
None
 0.73A 2qhfA-2go7A:
undetectable		 2qhfA-2go7A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_A_TDZA201_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 12 VAL A  83
SER A 132
THR A 131
ALA A 113
ARG A  72
 None
None
None
None
CL  A 209 (-4.2A)
 1.46A 2qm9A-2go7A:
undetectable		 2qm9A-2go7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QM9_B_TDZB202_1
(FATTY ACID-BINDING
PROTEIN, ADIPOCYTE)		 2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 12 VAL A  83
SER A 132
THR A 131
ALA A 113
ARG A  72
 None
None
None
None
CL  A 209 (-4.2A)
 1.39A 2qm9B-2go7A:
undetectable		 2qm9B-2go7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXO_B_TACB1211_1
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		5 / 11 LEU A  76
LEU A  54
VAL A  50
ILE A  34
VAL A  41
 CL  A 209 ( 4.9A)
None
CL  A 209 ( 4.5A)
None
None
 1.02A 2uxoB-2go7A:
undetectable		 2uxoB-2go7A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_2
(NUCLEAR RECEPTOR
ROR-GAMMA)		 2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		3 / 3 LEU A 120
VAL A  92
ARG A  90
 None
 0.84A 3b0wB-2go7A:
undetectable		 3b0wB-2go7A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K13_C_THHC643_1
(5-METHYLTETRAHYDROFO
LATE-HOMOCYSTEINE
METHYLTRANSFERASE)		 2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		3 / 3 ASN A 181
ASP A   9
ARG A  42
 None
MG  A 207 ( 2.4A)
None
 0.91A 3k13C-2go7A:
undetectable		 3k13C-2go7A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DC3_B_2FAB401_2
(ADENOSINE KINASE)		 2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 5 LEU A  93
ILE A 199
ALA A  96
PHE A   6
 None
 1.04A 4dc3B-2go7A:
3.7		 4dc3B-2go7A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UIG_A_EDTA501_0
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 6 ASN A 112
THR A 115
ASN A  80
GLU A  78
 None
 1.16A 5uigA-2go7A:
undetectable		 5uigA-2go7A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD4_B_STIB602_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2go7 HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY
(Streptococcus
pneumoniae) 		4 / 6 LEU A  93
VAL A 169
MET A  86
GLY A  88
 None
 1.02A 6hd4B-2go7A:
undetectable		 6hd4B-2go7A:
16.34