SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gop'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_1
(DIHYDROFOLATE
REDUCTASE)		 2gop TRILOBED PROTEASE
(Pyrococcus
furiosus) 		5 / 12 ILE A 297
LEU A 279
VAL A 265
LEU A 258
ILE A 294
 None
 0.99A 1df7A-2gopA:
undetectable		 1df7A-2gopA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_A_STRA1001_2
(MINERALOCORTICOID
RECEPTOR)		 2gop TRILOBED PROTEASE
(Pyrococcus
furiosus) 		4 / 4 LEU A 101
LEU A 109
SER A 108
LEU A 119
 None
 1.17A 1ya3A-2gopA:
undetectable		 1ya3A-2gopA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WM3_A_NFLA1301_1
(NMRA-LIKE FAMILY
DOMAIN CONTAINING
PROTEIN 1)		 2gop TRILOBED PROTEASE
(Pyrococcus
furiosus) 		4 / 6 LEU A 326
THR A 337
LEU A  31
ASP A  19
 None
 0.91A 2wm3A-2gopA:
undetectable		 2wm3A-2gopA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 2gop TRILOBED PROTEASE
(Pyrococcus
furiosus) 		4 / 8 ASP A 225
SER A 224
ASP A 272
ASP A 114
 None
 1.16A 3havA-2gopA:
undetectable		 3havA-2gopA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KMO_A_EAAA214_1
(GLUTATHIONE
S-TRANSFERASE P)		 2gop TRILOBED PROTEASE
(Pyrococcus
furiosus) 		5 / 9 PHE A 277
VAL A 265
GLY A 264
VAL A 275
ASN A 244
 None
 1.38A 3kmoA-2gopA:
undetectable		 3kmoA-2gopA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYT_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 2gop TRILOBED PROTEASE
(Pyrococcus
furiosus) 		4 / 5 PRO A  64
ASP A  19
ILE A  66
VAL A 314
 None
 1.36A 4hytA-2gopA:
undetectable		 4hytA-2gopA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 2gop TRILOBED PROTEASE
(Pyrococcus
furiosus) 		3 / 3 MET A 213
HIS A 179
GLY A 251
 None
 0.88A 5gwzB-2gopA:
undetectable		 5gwzB-2gopA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JKV_A_ASDA602_1
(AROMATASE)		 2gop TRILOBED PROTEASE
(Pyrococcus
furiosus) 		5 / 12 ILE A  66
ASP A 310
VAL A 314
LEU A 336
LEU A  50
 None
 1.20A 5jkvA-2gopA:
undetectable		 5jkvA-2gopA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 2gop TRILOBED PROTEASE
(Pyrococcus
furiosus) 		5 / 12 ALA A 268
GLU A 281
LEU A 287
ILE A 304
PHE A 280
 None
 1.33A 5vlmA-2gopA:
undetectable		 5vlmA-2gopA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WWS_B_SAMB501_0
(PUTATIVE
METHYLTRANSFERASE
NSUN6)		 2gop TRILOBED PROTEASE
(Pyrococcus
furiosus) 		5 / 12 GLY A 251
LYS A 252
LYS A 274
ASP A 291
GLY A 292
 None
 1.11A 5wwsB-2gopA:
undetectable		 5wwsB-2gopA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A93_B_8NUB3001_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2gop TRILOBED PROTEASE
(Pyrococcus
furiosus) 		4 / 5 ASP A 259
ILE A 294
PHE A 277
TYR A 247
 None
 1.25A 6a93B-2gopA:
undetectable		 6a93B-2gopA:
20.67