SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gp4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_A_SALA710_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 VAL A 437
VAL A 546
LEU A 553
ALA A 521
 None
 0.89A 1pthA-2gp4A:
undetectable		 1pthA-2gp4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PTH_B_SALB711_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 VAL A 437
VAL A 546
LEU A 553
ALA A 521
 None
 0.88A 1pthB-2gp4A:
0.2		 1pthB-2gp4A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_A_CLMA1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.78A 1usqA-2gp4A:
undetectable		 1usqA-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_B_CLMB1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.78A 1usqB-2gp4A:
undetectable		 1usqB-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.77A 1usqC-2gp4A:
undetectable		 1usqC-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_D_CLMD1142_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.79A 1usqD-2gp4A:
undetectable		 1usqD-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.81A 1usqE-2gp4A:
undetectable		 1usqE-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1USQ_F_CLMF1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.77A 1usqF-2gp4A:
undetectable		 1usqF-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UWH_B_BAXB1723_2
(B-RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 ILE A 287
VAL A 282
VAL A 101
ILE A 157
 None
 0.87A 1uwhB-2gp4A:
undetectable		 1uwhB-2gp4A:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_A_9CRA801_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 12 ILE A 291
LEU A 366
LEU A 295
ALA A 296
VAL A 318
 None
 0.96A 1xlsA-2gp4A:
undetectable		 1xlsA-2gp4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_B_9CRB802_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 12 ILE A 291
LEU A 366
LEU A 295
ALA A 296
VAL A 318
 None
 0.96A 1xlsB-2gp4A:
undetectable		 1xlsB-2gp4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_C_9CRC803_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 12 ILE A 291
LEU A 366
LEU A 295
ALA A 296
VAL A 318
 None
 0.96A 1xlsC-2gp4A:
undetectable		 1xlsC-2gp4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XLS_D_9CRD804_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 12 ILE A 291
LEU A 366
LEU A 295
ALA A 296
VAL A 318
 None
 0.95A 1xlsD-2gp4A:
undetectable		 1xlsD-2gp4A:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2COJ_A_GBNA420_1
(BRANCHED CHAIN
AMINOTRANSFERASE 1,
CYTOSOLIC)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 11 THR A 304
MET A 305
GLY A 597
THR A 596
VAL A 431
 None
 1.03A 2cojA-2gp4A:
undetectable
2cojB-2gp4A:
undetectable		 2cojA-2gp4A:
20.59
2cojB-2gp4A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.83A 2jkjA-2gp4A:
undetectable		 2jkjA-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.83A 2jkjB-2gp4A:
undetectable		 2jkjB-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.83A 2jkjC-2gp4A:
undetectable		 2jkjC-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_E_CLME1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.82A 2jkjE-2gp4A:
undetectable		 2jkjE-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_A_CLMA1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.79A 2jklA-2gp4A:
undetectable		 2jklA-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.80A 2jklB-2gp4A:
undetectable		 2jklB-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_C_CLMC1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.79A 2jklC-2gp4A:
undetectable		 2jklC-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_D_CLMD1145_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.80A 2jklD-2gp4A:
undetectable		 2jklD-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_E_CLME1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.80A 2jklE-2gp4A:
undetectable		 2jklE-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_F_CLMF1143_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 PRO A 177
GLY A 179
PRO A 180
ILE A 344
 None
 0.80A 2jklF-2gp4A:
undetectable		 2jklF-2gp4A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 8 ALA A 313
ILE A 316
GLY A 279
ILE A 278
 None
 0.76A 2o4nB-2gp4A:
undetectable		 2o4nB-2gp4A:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 TRP A 394
GLY A 375
THR A 372
GLN A 264
 None
 0.75A 2qx4A-2gp4A:
undetectable
2qx4B-2gp4A:
undetectable		 2qx4A-2gp4A:
16.22
2qx4B-2gp4A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7B_A_BEZA1529_0
(BENZOATE-COENZYME A
LIGASE)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 9 ALA A 314
ALA A 165
GLY A 164
GLY A 169
ILE A 278
 None
 1.27A 2v7bA-2gp4A:
2.6		 2v7bA-2gp4A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A7E_A_SAMA216_0
(CATECHOL
O-METHYLTRANSFERASE)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 12 GLU A 384
TYR A 215
ASN A 248
SER A 245
GLN A 231
 None
 1.39A 3a7eA-2gp4A:
1.4		 3a7eA-2gp4A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H0A_A_9RAA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 12 LEU A 366
LEU A 295
ALA A 296
VAL A 318
ILE A  12
 None
 0.83A 3h0aA-2gp4A:
undetectable		 3h0aA-2gp4A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 4 LEU A 365
PRO A 331
LEU A 360
ARG A 379
 None
 1.47A 3hcoA-2gp4A:
undetectable		 3hcoA-2gp4A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V1N_A_BEZA288_0
(2-HYDROXY-6-OXO-6-PH
ENYLHEXA-2,4-DIENOAT
E HYDROLASE)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 8 GLY A 351
GLY A 352
ILE A 344
LEU A 232
VAL A 336
 None
 1.42A 3v1nA-2gp4A:
undetectable		 3v1nA-2gp4A:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 ASP A 321
THR A   9
ILE A  12
PHE A 323
 None
 0.91A 4acbC-2gp4A:
2.6		 4acbC-2gp4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_A_GAIA407_0
(PROTEIN (ARGINASE))		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 ARG A  11
GLU A 595
LEU A 422
ASP A 322
 None
 1.44A 4cevA-2gp4A:
undetectable
4cevB-2gp4A:
undetectable		 4cevA-2gp4A:
19.49
4cevB-2gp4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_C_GAIC409_0
(PROTEIN (ARGINASE))		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 ASP A 322
ARG A  11
GLU A 595
LEU A 422
 None
 1.43A 4cevA-2gp4A:
undetectable
4cevC-2gp4A:
undetectable		 4cevA-2gp4A:
19.49
4cevC-2gp4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_D_GAID410_0
(PROTEIN (ARGINASE))		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 ARG A  11
GLU A 595
LEU A 422
ASP A 322
 None
 1.44A 4cevD-2gp4A:
undetectable
4cevE-2gp4A:
undetectable		 4cevD-2gp4A:
19.49
4cevE-2gp4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CEV_F_GAIF411_0
(PROTEIN (ARGINASE))		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 6 ARG A  11
GLU A 595
LEU A 422
ASP A 322
 None
 1.43A 4cevE-2gp4A:
undetectable
4cevF-2gp4A:
undetectable		 4cevE-2gp4A:
19.49
4cevF-2gp4A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_A_BEZA1000_0
(BENZOATE-COENZYME A
LIGASE)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 7 ALA A 314
ALA A 165
GLY A 164
GLY A 169
ILE A 278
 None
 1.18A 4eatA-2gp4A:
2.5		 4eatA-2gp4A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 12 PRO A 120
GLY A 121
GLY A 118
ASP A 509
GLY A 510
 None
 1.02A 4fp9D-2gp4A:
undetectable		 4fp9D-2gp4A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FWD_A_BO2A801_1
(TTC1975 PEPTIDASE)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 9 VAL A 473
VAL A 472
VAL A 546
ILE A 544
GLY A 541
 None
 1.16A 4fwdA-2gp4A:
undetectable		 4fwdA-2gp4A:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_0
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 12 PRO A 120
GLY A 121
GLY A 118
ASP A 509
GLY A 510
 None
 1.00A 4fzvA-2gp4A:
undetectable		 4fzvA-2gp4A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G0V_A_MIXA1301_1
(DNA TOPOISOMERASE
2-BETA)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 GLY A 476
ILE A 530
GLU A 528
GLN A 454
 None
 1.10A 4g0vA-2gp4A:
undetectable		 4g0vA-2gp4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_A_SAMA602_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 12 ALA A 314
GLY A 315
SER A  16
ASN A 283
GLY A 169
 None
 1.05A 4obwA-2gp4A:
undetectable		 4obwA-2gp4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I71_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 12 ALA A 334
PHE A 223
GLY A 219
GLY A 352
LEU A 356
 None
 0.96A 5i71A-2gp4A:
undetectable		 5i71A-2gp4A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 12 VAL A 281
PRO A 177
LEU A 174
LEU A 241
VAL A 373
 None
 1.18A 5im2A-2gp4A:
undetectable		 5im2A-2gp4A:
23.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JI0_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		5 / 11 ILE A 291
LEU A 366
LEU A 295
ALA A 296
VAL A 318
 None
 1.00A 5ji0A-2gp4A:
undetectable		 5ji0A-2gp4A:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 2gp4 6-PHOSPHOGLUCONATE
DEHYDRATASE
(Shewanella
oneidensis) 		4 / 7 VAL A 282
LEU A  24
GLY A 315
GLY A 164
 None
 0.69A 6eu9D-2gp4A:
undetectable		 6eu9D-2gp4A:
9.29