SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gp6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA156_1
(CALMODULIN)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 8 ILE A 305
LEU A 330
ILE A 291
GLU A 322
ILE A 399
 None
 1.47A 1linA-2gp6A:
undetectable		 1linA-2gp6A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 311
GLY A 352
GLU A 355
VAL A 197
VAL A 354
 None
 1.26A 1n2xA-2gp6A:
undetectable		 1n2xA-2gp6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V2X_A_SAMA400_0
(TRNA (GM18)
METHYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  63
GLY A 345
GLY A  61
MET A  85
ALA A 350
 None
 0.94A 1v2xA-2gp6A:
undetectable		 1v2xA-2gp6A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 339
PRO A 369
GLU A 355
PRO A 229
PHE A 230
 None
 1.31A 2admA-2gp6A:
undetectable		 2admA-2gp6A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_B_SAMB500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 339
PRO A 369
GLU A 355
PRO A 229
PHE A 230
 None
 1.30A 2admB-2gp6A:
undetectable		 2admB-2gp6A:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_B_SAMB1002_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 230
ALA A 325
ALA A 279
GLY A 404
GLY A 407
 None
 1.00A 2igtB-2gp6A:
undetectable		 2igtB-2gp6A:
24.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 9 ILE A 248
VAL A  15
THR A  16
ALA A  97
LEU A  93
 None
 1.14A 2m9qA-2gp6A:
undetectable		 2m9qA-2gp6A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 9 GLY A 195
SER A 110
ILE A 412
THR A   6
ILE A 184
 None
 1.25A 2nnhB-2gp6A:
undetectable		 2nnhB-2gp6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 9 GLU A 198
GLY A  60
PHE A 239
GLU A 202
ILE A 201
 None
 1.39A 2w98A-2gp6A:
undetectable		 2w98A-2gp6A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1353_1
(PROSTAGLANDIN
REDUCTASE 2)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 9 GLU A 198
GLY A  61
PHE A 239
GLU A 202
ILE A 201
 None
 1.39A 2w98A-2gp6A:
undetectable		 2w98A-2gp6A:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_C_CHDC151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 265
ILE A 412
GLY A 352
PRO A 340
LEU A 246
 None
 1.19A 3elzC-2gp6A:
undetectable		 3elzC-2gp6A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 7 GLY A 195
THR A 165
GLU A 156
ALA A 149
 None
 0.81A 3fpjB-2gp6A:
undetectable		 3fpjB-2gp6A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KKZ_A_SAMA301_0
(UNCHARACTERIZED
PROTEIN Q5LES9)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 173
GLY A 349
SER A 110
GLU A 355
ALA A 174
 None
 1.17A 3kkzA-2gp6A:
undetectable		 3kkzA-2gp6A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		3 / 3 GLU A  29
GLU A  95
ASN A  96
 None
 0.89A 3lp9B-2gp6A:
undetectable
3lp9D-2gp6A:
undetectable		 3lp9B-2gp6A:
17.87
3lp9D-2gp6A:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P5N_B_RBFB190_1
(RIBOFLAVIN UPTAKE
PROTEIN)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 LEU A 245
ASN A 400
GLY A 173
ALA A 176
ALA A 180
 None
 0.75A 3p5nB-2gp6A:
undetectable		 3p5nB-2gp6A:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		3 / 3 THR A 271
SER A 272
ARG A 286
 None
 0.66A 3phnA-2gp6A:
undetectable		 3phnA-2gp6A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_A_SAMA258_0
(PUTATIVE
METHYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 173
GLY A 349
SER A 110
GLU A 355
ALA A 174
 None
 1.22A 3sxjA-2gp6A:
undetectable		 3sxjA-2gp6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SXJ_B_SAMB258_0
(PUTATIVE
METHYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 173
GLY A 349
SER A 110
GLU A 355
ALA A 174
 None
 1.21A 3sxjB-2gp6A:
undetectable		 3sxjB-2gp6A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 173
GLY A 349
SER A 110
GLU A 355
ALA A 174
 None
 1.13A 3t7sA-2gp6A:
undetectable		 3t7sA-2gp6A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 173
GLY A 349
SER A 110
GLU A 355
ALA A 174
 None
 1.13A 3t7sB-2gp6A:
undetectable		 3t7sB-2gp6A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_C_SAMC300_0
(PUTATIVE
METHYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 173
GLY A 349
SER A 110
GLU A 355
ALA A 174
 None
 1.15A 3t7sC-2gp6A:
undetectable		 3t7sC-2gp6A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 173
GLY A 349
SER A 110
GLU A 355
ALA A 174
 None
 1.15A 3t7sD-2gp6A:
undetectable		 3t7sD-2gp6A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UR0_C_SVRC516_1
(RNA-DEPENDENT RNA
POLYMERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 9 PRO A 100
GLY A  98
ALA A  97
ALA A  19
LEU A 247
 None
 1.38A 3ur0C-2gp6A:
undetectable		 3ur0C-2gp6A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_A_C2FA302_0
(THYMIDYLATE SYNTHASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 11 SER A 356
ILE A 412
GLY A 415
PHE A 414
TYR A  12
 None
 1.30A 4fogA-2gp6A:
undetectable		 4fogA-2gp6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_C_C2FC302_0
(THYMIDYLATE SYNTHASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 11 SER A 356
ILE A 412
GLY A 415
PHE A 414
TYR A  12
 None
 1.35A 4fogC-2gp6A:
undetectable		 4fogC-2gp6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_E_D16E301_1
(THYMIDYLATE SYNTHASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 SER A 356
ILE A 412
GLY A 415
PHE A 414
TYR A  12
 None
 1.36A 4foxE-2gp6A:
undetectable		 4foxE-2gp6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOX_H_D16H301_1
(THYMIDYLATE SYNTHASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 11 SER A 356
ILE A 412
GLY A 415
PHE A 414
TYR A  12
 None
 1.37A 4foxH-2gp6A:
undetectable		 4foxH-2gp6A:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GH8_A_MTXA201_2
(DIHYDROFOLATE
REDUCTASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		3 / 3 LYS A 341
ILE A  42
THR A  31
 None
 0.88A 4gh8A-2gp6A:
undetectable		 4gh8A-2gp6A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L78_A_ACTA1327_0
(PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 4 VAL A  14
THR A 250
GLU A 251
GLU A 252
 None
 0.96A 4l78A-2gp6A:
1.2		 4l78A-2gp6A:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_A_ADNA402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		6 / 10 ALA A 329
ILE A 305
VAL A 308
ALA A 411
ALA A 294
ILE A 399
 None
 1.42A 4lbgA-2gp6A:
undetectable		 4lbgA-2gp6A:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBG_B_ADNB402_1
(PROBABLE SUGAR
KINASE PROTEIN)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		6 / 9 ALA A 329
ILE A 305
VAL A 308
ALA A 411
ALA A 294
ILE A 399
 None
 1.42A 4lbgB-2gp6A:
undetectable		 4lbgB-2gp6A:
25.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		7 / 12 ALA A 169
CYH A 170
PHE A 209
HIS A 311
THR A 313
HIS A 346
GLY A 404
 None
 0.83A 4ls7A-2gp6A:
59.7		 4ls7A-2gp6A:
36.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		8 / 12 GLY A 114
ALA A 169
CYH A 170
GLU A 198
HIS A 311
THR A 313
HIS A 346
GLY A 404
 None
 0.71A 4ls7A-2gp6A:
59.7		 4ls7A-2gp6A:
36.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_A_1X9A504_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 114
ALA A 169
GLU A 198
GLY A 404
PHE A 405
 None
 0.68A 4ls7A-2gp6A:
59.7		 4ls7A-2gp6A:
36.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4LS7_B_1X9B503_1
(3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		7 / 12 ALA A 169
CYH A 170
PHE A 209
HIS A 311
THR A 313
HIS A 346
GLY A 404
 None
 0.85A 4ls7A-2gp6A:
59.7
4ls7B-2gp6A:
59.6		 4ls7A-2gp6A:
36.76
4ls7B-2gp6A:
36.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 6 GLU A 198
GLU A 241
GLU A 202
GLU A 119
 None
 0.85A 4mi4A-2gp6A:
undetectable		 4mi4A-2gp6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 198
GLU A 241
GLU A 202
GLU A 119
 None
 0.84A 4mi4B-2gp6A:
undetectable
4mi4C-2gp6A:
undetectable		 4mi4B-2gp6A:
19.86
4mi4C-2gp6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MI4_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 198
GLU A 241
GLU A 202
GLU A 119
 None
 0.83A 4mi4A-2gp6A:
undetectable
4mi4C-2gp6A:
undetectable		 4mi4A-2gp6A:
19.86
4mi4C-2gp6A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_A_SPMA201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 198
GLU A 241
GLU A 202
GLU A 119
 None
 0.81A 4mj8A-2gp6A:
undetectable
4mj8C-2gp6A:
undetectable		 4mj8A-2gp6A:
17.40
4mj8C-2gp6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_B_SPMB201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 8 GLU A 198
GLU A 241
GLU A 202
GLU A 119
 None
 0.85A 4mj8B-2gp6A:
undetectable
4mj8C-2gp6A:
undetectable		 4mj8B-2gp6A:
17.40
4mj8C-2gp6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJ8_C_SPMC201_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 198
GLU A 241
GLU A 202
GLU A 119
 None
 0.99A 4mj8C-2gp6A:
undetectable		 4mj8C-2gp6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 12 HIS A 307
GLY A 318
ASP A 319
PHE A 230
THR A 371
 None
 1.41A 4mubA-2gp6A:
undetectable		 4mubA-2gp6A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 8 THR A  22
LEU A 358
LEU A 246
GLY A 243
 None
 0.88A 4r3aA-2gp6A:
undetectable		 4r3aA-2gp6A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_E_SPME202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 5 GLU A 198
GLU A 241
GLU A 202
GLU A 119
 None
 0.86A 4r87E-2gp6A:
undetectable		 4r87E-2gp6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R87_I_SPMI202_1
(SPERMIDINE
N1-ACETYLTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 198
GLU A 241
GLU A 202
GLU A 119
 None
 1.03A 4r87I-2gp6A:
undetectable		 4r87I-2gp6A:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_A_377A402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 9 ALA A 178
ALA A 174
ALA A 353
SER A 356
ALA A 180
 None
 1.28A 4twdA-2gp6A:
undetectable
4twdB-2gp6A:
undetectable
4twdC-2gp6A:
undetectable
4twdD-2gp6A:
undetectable
4twdE-2gp6A:
undetectable		 4twdA-2gp6A:
21.16
4twdB-2gp6A:
21.16
4twdC-2gp6A:
21.16
4twdD-2gp6A:
21.16
4twdE-2gp6A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 8 ALA A 178
ALA A 176
ILE A 177
ALA A 191
LEU A 246
 None
 1.41A 4v1fA-2gp6A:
undetectable
4v1fB-2gp6A:
undetectable		 4v1fA-2gp6A:
12.21
4v1fB-2gp6A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 154
VAL A 153
GLU A 156
SER A  90
LEU A 245
 None
 1.18A 4yb6A-2gp6A:
undetectable
4yb6E-2gp6A:
undetectable		 4yb6A-2gp6A:
20.85
4yb6E-2gp6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 154
VAL A 153
LEU A 107
SER A  90
LEU A 245
 None
 1.17A 4yb6A-2gp6A:
undetectable
4yb6E-2gp6A:
undetectable		 4yb6A-2gp6A:
20.85
4yb6E-2gp6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 154
VAL A 153
GLU A 156
SER A  90
LEU A 245
 None
 1.19A 4yb6B-2gp6A:
undetectable
4yb6C-2gp6A:
undetectable		 4yb6B-2gp6A:
20.85
4yb6C-2gp6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 154
VAL A 153
LEU A 107
SER A  90
LEU A 245
 None
 1.16A 4yb6B-2gp6A:
undetectable
4yb6C-2gp6A:
undetectable		 4yb6B-2gp6A:
20.85
4yb6C-2gp6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 154
VAL A 153
GLU A 156
SER A  90
LEU A 245
 None
 1.14A 4yb6C-2gp6A:
undetectable
4yb6F-2gp6A:
undetectable		 4yb6C-2gp6A:
20.85
4yb6F-2gp6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_C_HISC302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 154
VAL A 153
LEU A 107
SER A  90
LEU A 245
 None
 1.10A 4yb6C-2gp6A:
undetectable
4yb6F-2gp6A:
undetectable		 4yb6C-2gp6A:
20.85
4yb6F-2gp6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 107
SER A  90
LEU A 245
GLY A 154
VAL A 153
 None
 1.13A 4yb6A-2gp6A:
undetectable
4yb6D-2gp6A:
undetectable		 4yb6A-2gp6A:
20.85
4yb6D-2gp6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_D_HISD302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 SER A  90
LEU A 245
GLY A 154
VAL A 153
GLU A 156
 None
 1.16A 4yb6A-2gp6A:
undetectable
4yb6D-2gp6A:
undetectable		 4yb6A-2gp6A:
20.85
4yb6D-2gp6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 107
SER A  90
LEU A 245
GLY A 154
VAL A 153
 None
 1.09A 4yb6D-2gp6A:
undetectable
4yb6E-2gp6A:
0.6		 4yb6D-2gp6A:
20.85
4yb6E-2gp6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_E_HISE302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 SER A  90
LEU A 245
GLY A 154
VAL A 153
GLU A 156
 None
 1.14A 4yb6D-2gp6A:
undetectable
4yb6E-2gp6A:
0.6		 4yb6D-2gp6A:
20.85
4yb6E-2gp6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 107
SER A  90
LEU A 245
GLY A 154
VAL A 153
 None
 1.16A 4yb6B-2gp6A:
undetectable
4yb6F-2gp6A:
0.8		 4yb6B-2gp6A:
20.85
4yb6F-2gp6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 SER A  90
LEU A 245
GLY A 154
VAL A 153
GLU A 156
 None
 1.19A 4yb6B-2gp6A:
undetectable
4yb6F-2gp6A:
0.8		 4yb6B-2gp6A:
20.85
4yb6F-2gp6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 7 LEU A  64
THR A  30
LEU A  34
THR A  26
 None
 0.85A 4z91F-2gp6A:
undetectable
4z91G-2gp6A:
undetectable
4z91H-2gp6A:
undetectable
4z91I-2gp6A:
undetectable
4z91J-2gp6A:
undetectable		 4z91F-2gp6A:
20.69
4z91G-2gp6A:
20.69
4z91H-2gp6A:
20.69
4z91I-2gp6A:
20.69
4z91J-2gp6A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HIE_C_P06C801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 357
ILE A 261
CYH A 194
ASN A 400
 None
 0.89A 5hieC-2gp6A:
undetectable		 5hieC-2gp6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HPW_A_3CJA609_1
(LACTOPEROXIDASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 5 GLN A  70
HIS A  69
GLU A  65
ARG A  84
 None
 0.93A 5hpwA-2gp6A:
0.0		 5hpwA-2gp6A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TIX_B_OQRB302_0
(SULFOTRANSFERASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 10 ILE A 265
VAL A 410
PHE A 414
SER A 356
GLU A 355
 None
 1.45A 5tixB-2gp6A:
undetectable		 5tixB-2gp6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW9_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		4 / 8 SER A 402
GLY A 173
ALA A 171
GLU A 355
 None
 0.65A 5vw9A-2gp6A:
undetectable		 5vw9A-2gp6A:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_A_ACRA606_0
(ALPHA-AMYLASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		5 / 7 GLY A 242
GLY A 243
GLY A 196
GLY A 173
GLY A 352
 None
 1.09A 6ag0A-2gp6A:
undetectable		 6ag0A-2gp6A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2gp6 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2
(Mycobacterium
tuberculosis) 		3 / 3 ASP A  37
LEU A  34
ARG A  43
 None
 0.74A 7dfrA-2gp6A:
undetectable		 7dfrA-2gp6A:
17.42