SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gpc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DED_A_QPSA2001_1
(CYCLODEXTRIN
GLUCANOTRANSFERASE)		 2gpc IRON SUPEROXIDE
DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 TRP A 162
GLY A 145
ASN A  67
PRO A 147
 None
 1.26A 1dedA-2gpcA:
undetectable		 1dedA-2gpcA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OMB_D_IPHD2002_0
(BENCE JONES KWR
PROTEIN -
IMMUNOGLOBULIN LIGHT
CHAIN)		 2gpc IRON SUPEROXIDE
DISMUTASE
(Trypanosoma
cruzi) 		4 / 7 TYR A  28
HIS A  75
HIS A  31
TYR A  35
 None
FE2  A 195 (-3.2A)
None
None
 1.30A 2ombC-2gpcA:
undetectable
2ombD-2gpcA:
undetectable		 2ombC-2gpcA:
23.71
2ombD-2gpcA:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 2gpc IRON SUPEROXIDE
DISMUTASE
(Trypanosoma
cruzi) 		4 / 5 GLN A 193
PHE A  77
PHE A  73
TRP A 126
 None
 1.06A 2qmzA-2gpcA:
undetectable
2qmzB-2gpcA:
undetectable		 2qmzA-2gpcA:
20.59
2qmzB-2gpcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QX4_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2gpc IRON SUPEROXIDE
DISMUTASE
(Trypanosoma
cruzi) 		4 / 7 TRP A 126
GLN A 193
PHE A  77
PHE A  73
 None
 1.02A 2qx4A-2gpcA:
undetectable
2qx4B-2gpcA:
undetectable		 2qx4A-2gpcA:
20.59
2qx4B-2gpcA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DF2_A_4CHA506_0
(NADPH DEHYDROGENASE)		 2gpc IRON SUPEROXIDE
DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 TYR A 177
HIS A  27
HIS A  75
TYR A  78
 None
FE2  A 195 (-3.3A)
FE2  A 195 (-3.2A)
None
 1.48A 4df2A-2gpcA:
undetectable		 4df2A-2gpcA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA304_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2gpc IRON SUPEROXIDE
DISMUTASE
(Trypanosoma
cruzi) 		4 / 8 GLN A 193
PHE A  77
PHE A  73
TRP A 126
 None
 1.01A 4fgjA-2gpcA:
undetectable
4fgjB-2gpcA:
undetectable		 4fgjA-2gpcA:
20.92
4fgjB-2gpcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2gpc IRON SUPEROXIDE
DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 TRP A 126
GLN A 193
PHE A  77
PHE A  73
 None
 1.02A 4qogA-2gpcA:
undetectable
4qogB-2gpcA:
undetectable		 4qogA-2gpcA:
20.92
4qogB-2gpcA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 2gpc IRON SUPEROXIDE
DISMUTASE
(Trypanosoma
cruzi) 		4 / 6 VAL A 115
ALA A 125
VAL A 138
TYR A 139
 None
 0.99A 5i8fA-2gpcA:
undetectable		 5i8fA-2gpcA:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 2gpc IRON SUPEROXIDE
DISMUTASE
(Trypanosoma
cruzi) 		4 / 8 TYR A  78
PHE A 112
VAL A 185
SER A  81
 None
 1.11A 6huoC-2gpcA:
undetectable
6huoD-2gpcA:
undetectable		 6huoC-2gpcA:
17.02
6huoD-2gpcA:
18.97