SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gpr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SH9_B_RITB301_1
(POL POLYPROTEIN)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		5 / 8 ASP A  20
ASP A 153
ILE A  45
ILE A  23
GLY A 147
 None
 1.42A 1sh9A-2gprA:
undetectable		 1sh9A-2gprA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_A_MK1A901_2
(POL POLYPROTEIN)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		3 / 3 ASP A 103
VAL A 106
PRO A  55
 None
 0.75A 2avvA-2gprA:
undetectable		 2avvA-2gprA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_1
(PROTEASE)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		5 / 11 LEU A  60
ALA A  54
ILE A  80
ILE A  84
ILE A  72
 None
 1.02A 3ebzA-2gprA:
undetectable		 3ebzA-2gprA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		5 / 10 PRO A  47
LEU A  82
ILE A  84
SER A 126
GLY A  85
 None
 1.04A 3iluB-2gprA:
undetectable
3iluE-2gprA:
undetectable		 3iluB-2gprA:
20.92
3iluE-2gprA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		5 / 11 ILE A  84
SER A 126
GLY A  85
PRO A  47
LEU A  82
 None
 1.03A 3iluB-2gprA:
undetectable
3iluE-2gprA:
undetectable		 3iluB-2gprA:
20.92
3iluE-2gprA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KM6_A_EAAA222_1
(GLUTATHIONE
S-TRANSFERASE P)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		5 / 10 PHE A  34
GLY A  42
VAL A  33
ILE A  80
GLY A  40
 None
 1.30A 3km6A-2gprA:
undetectable		 3km6A-2gprA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA801_0
(GLUTAMATE RECEPTOR 2)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		4 / 8 ILE A  84
SER A 126
GLY A  85
PRO A  47
 None
 0.80A 3lslA-2gprA:
undetectable
3lslD-2gprA:
undetectable		 3lslA-2gprA:
20.92
3lslD-2gprA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID801_0
(GLUTAMATE RECEPTOR 2)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		4 / 8 PRO A  47
ILE A  84
SER A 126
GLY A  85
 None
 0.82A 3lslA-2gprA:
undetectable
3lslD-2gprA:
undetectable		 3lslA-2gprA:
20.92
3lslD-2gprA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SFE_C_TMGC1_1
(SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL
SUCCINATE
DEHYDROGENASE
CYTOCHROME B560
SUBUNIT,
MITOCHONDRIAL)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		4 / 8 PRO A  18
ILE A  45
SER A 129
ILE A  84
 None
 1.05A 3sfeB-2gprA:
undetectable
3sfeC-2gprA:
undetectable		 3sfeB-2gprA:
19.84
3sfeC-2gprA:
29.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		3 / 3 HIS A  68
VAL A  29
LEU A  86
 None
 0.77A 4m2vA-2gprA:
undetectable		 4m2vA-2gprA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y0Q_A_PX9A201_0
(BETA-LACTOGLOBULIN)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		5 / 12 VAL A 120
LEU A  82
ILE A  84
LYS A 123
VAL A 113
 None
 1.10A 4y0qA-2gprA:
undetectable		 4y0qA-2gprA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECL_D_ILED602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		4 / 6 ILE A 127
VAL A 115
VAL A 124
HIS A  68
 None
 0.90A 5eclD-2gprA:
undetectable		 5eclD-2gprA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5J4N_B_AG2B501_1
(ARGININE/AGMATINE
ANTIPORTER)		 2gpr GLUCOSE-PERMEASE IIA
COMPONENT
(Mycoplasma
capricolum) 		4 / 6 ILE A 127
GLY A  93
ASN A  94
ILE A  84
 None
 0.87A 5j4nB-2gprA:
undetectable		 5j4nB-2gprA:
15.32