SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gpy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DIT_P_2PPP1_1
(ALPHA-THROMBIN
PEPTIDE INHIBITOR
CVS995)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		4 / 6 LEU A  76
ILE A  81
ASP A 128
PRO A  55
 None
 1.23A 1ditH-2gpyA:
undetectable
1ditP-2gpyA:
undetectable		 1ditH-2gpyA:
21.09
1ditP-2gpyA:
6.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JG4_A_SAMA500_1
(PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		4 / 8 GLU A  60
GLY A  62
GLU A  85
ASP A 113
 None
None
None
ZN  A 306 ( 4.7A)
 0.54A 1jg4A-2gpyA:
11.9		 1jg4A-2gpyA:
25.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ADM_A_SAMA500_0
(ADENINE-N6-DNA-METHY
LTRANSFERASE TAQI)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 11 GLU A  60
GLU A  85
ASP A  87
ASP A 113
PHE A 142
 None
None
None
ZN  A 306 ( 4.7A)
None
 0.66A 2admA-2gpyA:
11.6		 2admA-2gpyA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX7_A_SALA1336_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		4 / 8 SER A  68
ARG A  71
LEU A  50
ALA A  75
 None
 0.91A 3ax7A-2gpyA:
undetectable		 3ax7A-2gpyA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DXY_A_SAMA1_0
(TRNA
(GUANINE-N(7)-)-METH
YLTRANSFERASE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		6 / 11 GLU A  60
GLY A  62
ILE A  84
GLU A  85
ASP A 113
ALA A 114
 None
None
None
None
ZN  A 306 ( 4.7A)
None
 0.70A 3dxyA-2gpyA:
12.5		 3dxyA-2gpyA:
27.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FUU_A_ADNA0_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 12 GLY A  62
GLU A  85
ASP A  87
ASP A 113
ALA A 114
 None
None
None
ZN  A 306 ( 4.7A)
None
 0.50A 3fuuA-2gpyA:
14.3		 3fuuA-2gpyA:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRV_A_ADNA300_1
(DIMETHYLADENOSINE
TRANSFERASE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 11 GLY A  62
GLU A  85
ASP A  87
ASP A 113
ALA A 114
 None
None
None
ZN  A 306 ( 4.7A)
None
 0.49A 3grvA-2gpyA:
13.8		 3grvA-2gpyA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GRY_A_SAMA300_0
(DIMETHYLADENOSINE
TRANSFERASE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		6 / 12 GLU A  60
GLY A  62
GLU A  85
ASP A  87
ASP A 113
ALA A 114
 None
None
None
None
ZN  A 306 ( 4.7A)
None
 0.50A 3gryA-2gpyA:
13.9		 3gryA-2gpyA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_B_SAMB301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 11 GLY A  62
GLU A  85
ASP A 113
ALA A 114
GLN A 138
 None
None
ZN  A 306 ( 4.7A)
None
None
 0.99A 3id5B-2gpyA:
14.2		 3id5B-2gpyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID5_F_SAMF301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 11 GLY A  62
GLU A  85
ASP A 113
ALA A 114
GLN A 138
 None
None
ZN  A 306 ( 4.7A)
None
None
 0.99A 3id5F-2gpyA:
14.2		 3id5F-2gpyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 12 GLY A  62
ALA A  64
ASP A 113
ALA A 114
ASP A 133
 None
None
ZN  A 306 ( 4.7A)
None
None
 0.77A 3id6C-2gpyA:
14.3		 3id6C-2gpyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ID6_C_SAMC301_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 12 GLY A  62
ALA A  64
GLU A  85
ASP A 113
ALA A 114
 None
None
None
ZN  A 306 ( 4.7A)
None
 0.38A 3id6C-2gpyA:
14.3		 3id6C-2gpyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_H_PZIH800_0
(GLUTAMATE RECEPTOR 2)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		4 / 8 TYR A  67
PRO A  17
LEU A  40
ASP A  39
 None
 0.98A 3lsfH-2gpyA:
undetectable		 3lsfH-2gpyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_F_SAMF228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		6 / 12 GLY A  62
ALA A  64
GLU A  85
ASP A 113
ALA A 114
ASP A 133
 None
None
None
ZN  A 306 ( 4.7A)
None
None
 0.82A 3nmuA-2gpyA:
undetectable
3nmuF-2gpyA:
10.8		 3nmuA-2gpyA:
20.93
3nmuF-2gpyA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 11 GLY A  62
ALA A  64
GLU A  85
ALA A 114
ASP A 133
 None
 0.73A 3nmuB-2gpyA:
undetectable
3nmuJ-2gpyA:
13.4		 3nmuB-2gpyA:
20.93
3nmuJ-2gpyA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NMU_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 11 GLY A  62
ALA A  64
ILE A  84
GLU A  85
ASP A 133
 None
 0.79A 3nmuB-2gpyA:
undetectable
3nmuJ-2gpyA:
13.4		 3nmuB-2gpyA:
20.93
3nmuJ-2gpyA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_L_PM6L1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		4 / 8 SER A  68
ARG A  71
LEU A  50
ALA A  75
 None
 0.96A 3ns1L-2gpyA:
undetectable		 3ns1L-2gpyA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_I_SAMI228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 12 GLY A  62
ALA A  64
ILE A  84
ASP A 113
ASP A 133
 None
None
None
ZN  A 306 ( 4.7A)
None
 0.93A 3nvkI-2gpyA:
13.8		 3nvkI-2gpyA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NVK_J_SAMJ228_0
(FIBRILLARIN-LIKE
RRNA/TRNA
2'-O-METHYLTRANSFERA
SE
NOP5/NOP56 RELATED
PROTEIN)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 12 GLY A  62
ALA A  64
GLU A  85
ASP A 113
ALA A 114
 None
None
None
ZN  A 306 ( 4.7A)
None
 0.72A 3nvkF-2gpyA:
undetectable
3nvkJ-2gpyA:
14.0		 3nvkF-2gpyA:
24.85
3nvkJ-2gpyA:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_SAMA401_1
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		3 / 3 GLU A  85
ASP A  87
ASP A 113
 None
None
ZN  A 306 ( 4.7A)
 0.58A 4gc9A-2gpyA:
9.8		 4gc9A-2gpyA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 12 MET A  26
TYR A  67
ILE A 107
ALA A  94
TYR A  91
 None
 1.03A 5kvaA-2gpyA:
21.0		 5kvaA-2gpyA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 12 MET A  26
TYR A  67
ILE A 107
ALA A  94
TYR A  91
 None
 1.06A 5kvaB-2gpyA:
20.9		 5kvaB-2gpyA:
26.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_A_SAMA306_0
(METHYLTRANSFERASE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 12 GLU A  60
GLY A  62
TYR A  67
ALA A 114
PHE A 131
 None
 0.66A 5n5dA-2gpyA:
20.7		 5n5dA-2gpyA:
29.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N5D_B_SAMB303_0
(METHYLTRANSFERASE)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		5 / 12 GLU A  60
TYR A  67
ILE A  84
ALA A 114
PHE A 131
 None
 0.72A 5n5dB-2gpyA:
20.7		 5n5dB-2gpyA:
29.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		8 / 12 PRO A  36
ILE A  37
GLU A  60
GLY A  62
ALA A  64
TYR A  67
ALA A 114
PHE A 142
 None
 0.70A 5zw4A-2gpyA:
26.8		 5zw4A-2gpyA:
49.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZW4_A_SAMA302_0
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		7 / 12 PRO A  36
ILE A  37
MET A  38
GLU A  60
GLY A  62
ALA A  64
TYR A  67
 None
 0.68A 5zw4A-2gpyA:
26.8		 5zw4A-2gpyA:
49.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		4 / 6 GLU A  85
ARG A  90
ASP A 113
ASP A 133
 None
None
ZN  A 306 ( 4.7A)
None
 0.75A 5zw4A-2gpyA:
26.8		 5zw4A-2gpyA:
49.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ZW4_A_SAMA302_1
(PUTATIVE
O-METHYLTRANSFERASE
YRRM)		 2gpy O-METHYLTRANSFERASE
(Bacillus
halodurans) 		4 / 6 SER A  68
GLU A  85
ARG A  90
ASP A 113
 None
None
None
ZN  A 306 ( 4.7A)
 0.79A 5zw4A-2gpyA:
26.8		 5zw4A-2gpyA:
49.79