SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gq0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ETA_1_T441128_1
(TRANSTHYRETIN)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 LEU A 399
GLU A 417
ALA A 397
LEU A 382
 None
 1.21A 1eta1-2gq0A:
undetectable		 1eta1-2gq0A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_C_STRC3001_1
(MINERALOCORTICOID
RECEPTOR)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 LEU A 357
LEU A 360
LEU A 363
ALA A 364
LEU A 400
 None
 0.75A 1ya3C-2gq0A:
undetectable		 1ya3C-2gq0A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YAJ_D_BEZD2385_0
(CES1 PROTEIN)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 LEU A 348
LEU A 299
LEU A 324
LEU A 330
 None
 0.87A 1yajD-2gq0A:
undetectable		 1yajD-2gq0A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXD_A_RWFA2001_1
(SERUM ALBUMIN)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 9 TYR A 371
PHE A 320
LEU A 382
ARG A 401
LEU A 400
 None
 0.93A 2bxdA-2gq0A:
undetectable		 2bxdA-2gq0A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIQ_A_STIA1001_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 VAL A 356
LEU A 360
MET A 468
ARG A 322
 None
 1.09A 2oiqA-2gq0A:
undetectable		 2oiqA-2gq0A:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 LEU A 382
THR A 353
VAL A 356
ALA A 395
 None
 0.97A 3ax9A-2gq0A:
undetectable		 3ax9A-2gq0A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_A_LEIA16_0
(COIL SER L16D-PEN)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 6 GLN A 358
LEU A 360
GLU A 361
LEU A 399
 None
 0.82A 3h5gA-2gq0A:
undetectable
3h5gC-2gq0A:
undetectable		 3h5gA-2gq0A:
8.33
3h5gC-2gq0A:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 8 ASP A 476
PRO A 479
GLN A 393
GLU A 394
 None
 0.90A 3oyaA-2gq0A:
undetectable		 3oyaA-2gq0A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 6 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.98A 3wg7P-2gq0A:
undetectable
3wg7W-2gq0A:
undetectable		 3wg7P-2gq0A:
20.30
3wg7W-2gq0A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.97A 3x2qP-2gq0A:
undetectable
3x2qW-2gq0A:
undetectable		 3x2qP-2gq0A:
20.30
3x2qW-2gq0A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AQL_A_TXCA1452_2
(GUANINE DEAMINASE)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 HIS A 265
LEU A 348
LEU A 299
ASP A 329
 None
 1.30A 4aqlA-2gq0A:
undetectable		 4aqlA-2gq0A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.95A 5b1aC-2gq0A:
undetectable
5b1aJ-2gq0A:
undetectable		 5b1aC-2gq0A:
20.30
5b1aJ-2gq0A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.91A 5b1aP-2gq0A:
undetectable
5b1aW-2gq0A:
undetectable		 5b1aP-2gq0A:
20.30
5b1aW-2gq0A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.94A 5b1bP-2gq0A:
undetectable
5b1bW-2gq0A:
undetectable		 5b1bP-2gq0A:
20.30
5b1bW-2gq0A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.94A 5b3sC-2gq0A:
undetectable
5b3sJ-2gq0A:
undetectable		 5b3sC-2gq0A:
20.30
5b3sJ-2gq0A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.92A 5b3sP-2gq0A:
undetectable		 5b3sP-2gq0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 12 PHE A 320
ILE A 280
LEU A 318
LEU A 357
PHE A 374
 None
 1.24A 5im2A-2gq0A:
undetectable		 5im2A-2gq0A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V02_R_657R201_0
(CALMODULIN-1
SMALL CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL
PROTEIN 2)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		5 / 10 LEU A 382
VAL A 381
LEU A 360
VAL A 321
ILE A 280
 None
 1.08A 5v02B-2gq0A:
undetectable
5v02R-2gq0A:
undetectable		 5v02B-2gq0A:
19.14
5v02R-2gq0A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1B_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 5 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 1.02A 5x1bP-2gq0A:
undetectable		 5x1bP-2gq0A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		4 / 7 LEU A 382
PHE A 378
PHE A 374
LEU A 360
 None
 0.94A 5zcqP-2gq0A:
undetectable
5zcqW-2gq0A:
undetectable		 5zcqP-2gq0A:
20.30
5zcqW-2gq0A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2gq0 CHAPERONE PROTEIN
HTPG
(Escherichia
coli) 		3 / 3 ASP A 367
LEU A 363
ARG A 401
 None
 0.90A 7dfrA-2gq0A:
undetectable		 7dfrA-2gq0A:
18.33