SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gq3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1D8C_A_SORA4000_0
(MALATE SYNTHASE G)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 GLN A  61
HIS A 469
PRO A 706
 None
 0.10A 1d8cA-2gq3A:
52.7		 1d8cA-2gq3A:
57.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_C_EAAC223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 8 TYR A 608
GLY A 618
ARG A 634
VAL A 118
 None
None
None
COA  A 800 (-3.9A)
 0.93A 1gsfC-2gq3A:
2.1		 1gsfC-2gq3A:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_M_TRPM81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 11 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.12A 1gtnM-2gq3A:
undetectable
1gtnN-2gq3A:
undetectable		 1gtnM-2gq3A:
7.86
1gtnN-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_U_TRPU81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.07A 1gtnU-2gq3A:
undetectable
1gtnV-2gq3A:
undetectable		 1gtnU-2gq3A:
7.86
1gtnV-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_3
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 5 ILE A 581
LEU A 579
VAL A 440
ALA A 444
 None
 0.92A 1mz9C-2gq3A:
undetectable		 1mz9C-2gq3A:
6.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QU2_A_MRCA1993_2
(ISOLEUCYL-TRNA
SYNTHETASE)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 597
TRP A 647
LYS A 513
 None
 1.06A 1qu2A-2gq3A:
undetectable		 1qu2A-2gq3A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UTD_T_TRPT81_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.10A 1utdT-2gq3A:
undetectable
1utdU-2gq3A:
undetectable		 1utdT-2gq3A:
7.86
1utdU-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 511
GLY A 512
THR A 458
ASP A 494
 None
 0.87A 2a1mA-2gq3A:
undetectable		 2a1mA-2gq3A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IDW_B_017B401_1
(PROTEASE)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 11 ALA A 509
ILE A 456
GLY A 430
ALA A 450
ILE A 100
 None
 1.01A 2idwA-2gq3A:
undetectable		 2idwA-2gq3A:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J1G_F_SC2F1290_1
(FICOLIN-2)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 LEU A 344
LEU A  54
THR A 409
ARG A  57
GLU A 405
 None
 1.45A 2j1gE-2gq3A:
0.0
2j1gF-2gq3A:
0.0		 2j1gE-2gq3A:
15.32
2j1gF-2gq3A:
15.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LBD_A_REAA500_1
(RETINOIC ACID
RECEPTOR GAMMA)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 12 PHE A 367
ILE A  12
ARG A   4
GLY A  38
LEU A 420
 None
 1.26A 2lbdA-2gq3A:
undetectable		 2lbdA-2gq3A:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTH_A_IMNA301_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 ASP A 140
TYR A 139
LYS A 258
 None
 1.17A 2othA-2gq3A:
undetectable		 2othA-2gq3A:
9.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNJ_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 429
ARG A 452
GLY A 369
TRP A 291
 None
 1.07A 2pnjB-2gq3A:
undetectable		 2pnjB-2gq3A:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 115
ALA A 265
ALA A 535
ALA A 531
THR A 528
 None
 1.18A 2x2nA-2gq3A:
undetectable		 2x2nA-2gq3A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 12 PRO A 115
ALA A 265
ALA A 535
ALA A 531
THR A 528
 None
 1.18A 2x2nB-2gq3A:
undetectable		 2x2nB-2gq3A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 6 HIS A 551
GLN A 510
ALA A 265
THR A 268
 None
 1.03A 2xfhA-2gq3A:
undetectable		 2xfhA-2gq3A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_1
(PROTEASE)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 ALA A 509
ILE A 456
GLY A 430
ALA A 450
ILE A 100
 None
 0.97A 3ekwA-2gq3A:
undetectable		 3ekwA-2gq3A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL9_A_DR7A100_2
(PROTEASE)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 GLY A 475
ALA A 474
ILE A  64
ILE A 468
THR A 580
 None
 0.91A 3el9B-2gq3A:
undetectable		 3el9B-2gq3A:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 339
GLU A 360
ASP A 280
 MLT  A 900 (-2.9A)
None
None
 0.88A 3g2oA-2gq3A:
undetectable		 3g2oA-2gq3A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GP0_A_NILA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 11)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 118
LEU A 122
LEU A 128
ILE A 269
 COA  A 800 (-3.9A)
EPE  A5000 (-4.1A)
None
None
 0.71A 3gp0A-2gq3A:
undetectable		 3gp0A-2gq3A:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCN_B_CHDB2_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 294
LEU A 299
ARG A 312
 None
None
COA  A 800 (-2.7A)
 0.55A 3hcnB-2gq3A:
undetectable		 3hcnB-2gq3A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK3_A_0LIA1_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 442
ILE A 489
MET A 432
ARG A 534
 None
 1.32A 3ik3A-2gq3A:
undetectable		 3ik3A-2gq3A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB3_A_SAMA1102_1
(STRUCTURAL PROTEIN
VP3)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 680
ASP A 670
ASP A 614
 None
 0.85A 3jb3A-2gq3A:
0.5		 3jb3A-2gq3A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 114
VAL A 558
PRO A 533
GLY A 236
ALA A 265
 None
 0.86A 3ku1H-2gq3A:
undetectable		 3ku1H-2gq3A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L2W_A_ELVA397_1
(INTEGRASE)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 5 ASP A 462
ASP A 274
PRO A 398
GLU A 434
 MG  A1000 ( 2.9A)
MG  A1000 ( 4.9A)
None
MG  A1000 ( 2.7A)
 1.40A 3l2wA-2gq3A:
0.0		 3l2wA-2gq3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O14_A_NIOA300_1
(ANTI-ECFSIGMA
FACTOR, CHRR)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 141
VAL A 526
VAL A 147
LEU A 142
 None
 0.51A 3o14A-2gq3A:
undetectable		 3o14A-2gq3A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 597
LEU A 643
LEU A 698
 None
 0.75A 3ohtA-2gq3A:
undetectable		 3ohtA-2gq3A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 GLU A 597
LEU A 643
LEU A 698
 None
 0.74A 3ohtB-2gq3A:
undetectable		 3ohtB-2gq3A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 6 ASN A 315
TYR A 320
GLU A 240
ILE A 261
 None
 1.08A 3q5sA-2gq3A:
undetectable		 3q5sA-2gq3A:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 8 ILE A 429
ARG A 452
GLY A 369
TRP A 291
 None
 0.88A 3w1wA-2gq3A:
undetectable		 3w1wA-2gq3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1507_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 638
LYS A 399
ARG A 634
 None
MG  A1000 ( 4.2A)
None
 1.12A 3w1wA-2gq3A:
0.4
3w1wB-2gq3A:
0.3		 3w1wA-2gq3A:
19.75
3w1wB-2gq3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB506_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 ARG A 634
ARG A 638
LYS A 399
 None
None
MG  A1000 ( 4.2A)
 1.10A 3w1wA-2gq3A:
0.3
3w1wB-2gq3A:
0.3		 3w1wA-2gq3A:
19.75
3w1wB-2gq3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_C_SVRC301_1
(NUCLEOCAPSID PROTEIN)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 8 GLY A 293
ASN A 295
LYS A 296
PHE A  19
 None
 0.92A 4j4vC-2gq3A:
undetectable		 4j4vC-2gq3A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M11_A_MXMA606_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 12 ILE A 653
VAL A 658
LEU A 662
LEU A 648
LEU A 643
 None
 1.41A 4m11A-2gq3A:
undetectable		 4m11A-2gq3A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA7_A_P2ZA301_1
(MAJOR PRION PROTEIN)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 644
ILE A 468
GLN A 642
THR A 710
 None
 0.83A 4ma7A-2gq3A:
undetectable		 4ma7A-2gq3A:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 12 GLY A 651
VAL A 652
ILE A 653
LEU A 643
ILE A 605
 None
 1.08A 4pd4C-2gq3A:
2.2		 4pd4C-2gq3A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 11 GLY A 500
ILE A 456
GLY A 507
ILE A 100
PHE A  98
 None
 0.94A 4qoiA-2gq3A:
undetectable
4qoiB-2gq3A:
undetectable		 4qoiA-2gq3A:
15.31
4qoiB-2gq3A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCK_B_SAMB2409_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 6 SER A 640
GLY A 607
GLU A 632
ASP A 670
 None
 1.04A 4uckB-2gq3A:
undetectable		 4uckB-2gq3A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 11 LEU A 714
PHE A 721
GLY A 607
LEU A 698
ALA A 694
 None
 1.10A 4wnuA-2gq3A:
undetectable		 4wnuA-2gq3A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_B_PAUB601_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 7 ALA A 540
GLU A 493
GLY A 512
GLY A 536
 None
 0.81A 5e26A-2gq3A:
undetectable
5e26B-2gq3A:
undetectable		 5e26A-2gq3A:
19.75
5e26B-2gq3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E26_C_PAUC602_0
(PANTOTHENATE KINASE
2, MITOCHONDRIAL)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 7 GLU A 493
GLY A 512
GLY A 536
ALA A 540
 None
 0.78A 5e26C-2gq3A:
undetectable
5e26D-2gq3A:
undetectable		 5e26C-2gq3A:
19.75
5e26D-2gq3A:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 448
HIS A 343
ALA A 449
THR A 409
ILE A 429
 None
 0.98A 5eeuI-2gq3A:
undetectable
5eeuJ-2gq3A:
undetectable		 5eeuI-2gq3A:
7.86
5eeuJ-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEU_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.11A 5eeuO-2gq3A:
undetectable
5eeuP-2gq3A:
undetectable		 5eeuO-2gq3A:
7.86
5eeuP-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 448
HIS A 343
ALA A 449
THR A 409
ILE A 429
 None
 0.98A 5eevI-2gq3A:
undetectable
5eevJ-2gq3A:
undetectable		 5eevI-2gq3A:
7.86
5eevJ-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEV_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.11A 5eevO-2gq3A:
undetectable
5eevP-2gq3A:
undetectable		 5eevO-2gq3A:
7.86
5eevP-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_I_TRPI101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 12 ALA A 448
HIS A 343
ALA A 449
THR A 409
ILE A 429
 None
 0.98A 5eewI-2gq3A:
undetectable
5eewJ-2gq3A:
undetectable		 5eewI-2gq3A:
7.86
5eewJ-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEW_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.11A 5eewO-2gq3A:
undetectable
5eewP-2gq3A:
undetectable		 5eewO-2gq3A:
7.86
5eewP-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEX_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.11A 5eexO-2gq3A:
undetectable
5eexP-2gq3A:
undetectable		 5eexO-2gq3A:
7.86
5eexP-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEY_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.11A 5eeyO-2gq3A:
undetectable
5eeyP-2gq3A:
undetectable		 5eeyO-2gq3A:
7.86
5eeyP-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EEZ_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.11A 5eezO-2gq3A:
undetectable
5eezP-2gq3A:
undetectable		 5eezO-2gq3A:
7.86
5eezP-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF0_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.11A 5ef0O-2gq3A:
undetectable
5ef0P-2gq3A:
undetectable		 5ef0O-2gq3A:
7.86
5ef0P-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF1_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.11A 5ef1O-2gq3A:
undetectable
5ef1P-2gq3A:
undetectable		 5ef1O-2gq3A:
7.86
5ef1P-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF2_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.11A 5ef2O-2gq3A:
undetectable
5ef2P-2gq3A:
undetectable		 5ef2O-2gq3A:
7.86
5ef2P-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_P_TRPP101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 HIS A 343
ALA A 449
THR A 409
ILE A 429
ALA A 448
 None
 1.11A 5ef3O-2gq3A:
undetectable
5ef3P-2gq3A:
undetectable		 5ef3O-2gq3A:
7.86
5ef3P-2gq3A:
7.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 8 LEU A 335
ILE A 386
GLY A 391
THR A 426
 None
 0.73A 5eseA-2gq3A:
undetectable		 5eseA-2gq3A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_B_X2NB590_1
(CYP51 VARIANT1)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 12 TYR A 555
GLN A 557
ILE A 639
THR A 517
HIS A 551
 None
 1.23A 5fsaB-2gq3A:
undetectable		 5fsaB-2gq3A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQC_D_51GD600_1
(BIFUNCTIONAL AAC/APH)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 ASP A  58
TYR A 709
GLU A 711
GLU A 434
GLU A 405
 None
None
None
MG  A1000 ( 2.7A)
None
 1.49A 5iqcD-2gq3A:
2.5		 5iqcD-2gq3A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IQE_D_NMYD600_1
(BIFUNCTIONAL AAC/APH)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 12 ASP A  58
TYR A 709
GLU A 711
GLU A 434
GLU A 405
 None
None
None
MG  A1000 ( 2.7A)
None
 1.45A 5iqeD-2gq3A:
0.1		 5iqeD-2gq3A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JH7_B_6K9B503_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 7 LEU A 370
VAL A 419
ILE A 350
VAL A  39
 None
 1.19A 5jh7C-2gq3A:
undetectable		 5jh7C-2gq3A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_A_SAMA501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 11 PRO A 582
GLU A 473
GLY A 475
LEU A 579
GLN A  61
 None
 1.14A 5o96A-2gq3A:
2.7
5o96B-2gq3A:
2.5		 5o96A-2gq3A:
16.45
5o96B-2gq3A:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UUN_A_ACTA305_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 THR A 470
MET A 472
HIS A  68
 None
 0.82A 5uunA-2gq3A:
2.0		 5uunA-2gq3A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 501
THR A 458
ASN A 457
 None
 0.69A 6baaE-2gq3A:
undetectable		 6baaE-2gq3A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 501
THR A 458
ASN A 457
 None
 0.68A 6baaF-2gq3A:
undetectable		 6baaF-2gq3A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 501
THR A 458
ASN A 457
 None
 0.69A 6baaG-2gq3A:
undetectable		 6baaG-2gq3A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		3 / 3 LEU A 501
THR A 458
ASN A 457
 None
 0.69A 6baaH-2gq3A:
undetectable		 6baaH-2gq3A:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D9H_R_ADNR400_1
(CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 10 VAL A 396
LEU A 335
ASN A 387
ILE A 109
THR A 267
 None
 1.41A 6d9hR-2gq3A:
undetectable		 6d9hR-2gq3A:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 7 VAL A 542
ILE A 269
GLY A 297
ALA A 131
 None
 0.91A 6hd6B-2gq3A:
undetectable		 6hd6B-2gq3A:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6J20_A_GBQA1201_1
(SUBSTANCE-P
RECEPTOR,ENDOLYSIN)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 7 ILE A 269
GLN A 116
VAL A 396
TRP A 291
 None
 0.95A 6j20A-2gq3A:
0.0		 6j20A-2gq3A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_B_FK5B201_0
(PEPTIDYLPROLYL
ISOMERASE)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		5 / 12 TYR A  81
ARG A 436
TRP A  67
PHE A  84
ILE A 468
 None
 1.15A 6mkeB-2gq3A:
undetectable
6mkeC-2gq3A:
undetectable		 6mkeB-2gq3A:
8.79
6mkeC-2gq3A:
8.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 2gq3 MALATE SYNTHASE G
(Mycobacterium
tuberculosis) 		4 / 8 TRP A 612
HIS A 715
ARG A 638
GLU A 434
 None
None
None
MG  A1000 ( 2.7A)
 1.07A 6mn4C-2gq3A:
undetectable		 6mn4C-2gq3A:
19.38