SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gqc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4PWD_A_NVPA901_1 (HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT)	2gqc	RHOMBOID INTRAMEMBRANE PROTEASE (Pseudomonas aeruginosa)	4 / 8	PRO A 59 LEU A 25 VAL A 42 LEU A 21	None	0.95A	4pwdA-2gqcA: undetectable	4pwdA-2gqcA: 8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6AN0_A_HISA520_0 (HISTIDINOL DEHYDROGENASE)	2gqc	RHOMBOID INTRAMEMBRANE PROTEASE (Pseudomonas aeruginosa)	4 / 6	GLU A 68 ARG A 57 GLU A 60 ALA A 70	None	1.23A	6an0A-2gqcA: undetectable	6an0A-2gqcA: 9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6ELI_A_T27A701_1 (REVERSE TRANSCRIPTASE)	2gqc	RHOMBOID INTRAMEMBRANE PROTEASE (Pseudomonas aeruginosa)	5 / 12	PRO A 10 VAL A 42 VAL A 6 PRO A 28 LEU A 22	None	1.49A	6eliA-2gqcA: undetectable	6eliA-2gqcA: 20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6EXI_D_ADND502_1 (ADENOSYLHOMOCYSTEINA SE)	2gqc	RHOMBOID INTRAMEMBRANE PROTEASE (Pseudomonas aeruginosa)	3 / 3	LEU A 47 ASN A 26 LEU A 40	None	0.60A	6exiD-2gqcA: undetectable	6exiD-2gqcA: 24.36

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["4PWD_A_NVPA901_1","HIV-1 REVERSE TRANSCRIPTASE, P66 SUBUNIT","2gqc","RHOMBOID INTRAMEMBRANE PROTEASE","Pseudomonas aeruginosa",4,"PRO A  59;LEU A  25;VAL A  42;LEU A  21","None","0.95A","4pwdA-2gqcA:undetectable","4pwdA-2gqcA:8.45"],["6AN0_A_HISA520_0","HISTIDINOL DEHYDROGENASE","2gqc","RHOMBOID INTRAMEMBRANE PROTEASE","Pseudomonas aeruginosa",4,"GLU A  68;ARG A  57;GLU A  60;ALA A  70","None","1.23A","6an0A-2gqcA:undetectable","6an0A-2gqcA:9.40"],["6ELI_A_T27A701_1","REVERSE TRANSCRIPTASE","2gqc","RHOMBOID INTRAMEMBRANE PROTEASE","Pseudomonas aeruginosa",5,"PRO A  10;VAL A  42;VAL A   6;PRO A  28;LEU A  22","None","1.49A","6eliA-2gqcA:undetectable","6eliA-2gqcA:20.83"],["6EXI_D_ADND502_1","ADENOSYLHOMOCYSTEINASE","2gqc","RHOMBOID INTRAMEMBRANE PROTEASE","Pseudomonas aeruginosa",3,"LEU A  47;ASN A  26;LEU A  40","None","0.60A","6exiD-2gqcA:undetectable","6exiD-2gqcA:24.36"]]