SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gqi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_A_T44A428_1
(TRANSTHYRETIN
THR119MET VARIANT)		 2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 4 LYS A  29
LEU A  14
ALA A  12
LEU A  61
 None
 1.48A 1f86A-2gqiA:
undetectable		 1f86A-2gqiA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_A_9CRA131_1
(TRANSTHYRETIN)		 2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 6 LYS A  29
LEU A  14
ALA A  12
LEU A  61
 None
 1.31A 1tyrA-2gqiA:
undetectable		 1tyrA-2gqiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ROX_A_T44A128_1
(TRANSTHYRETIN)		 2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 4 LYS A  29
LEU A  14
ALA A  12
LEU A  61
 None
 1.27A 2roxA-2gqiA:
undetectable		 2roxA-2gqiA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 8 LYS A  18
SER A  26
THR A  51
ASP A  23
 None
 1.19A 5t8sB-2gqiA:
undetectable		 5t8sB-2gqiA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_A_6J3A201_0
(TRANSTHYRETIN)		 2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 4 LYS A  29
LEU A  14
ALA A  12
LEU A  61
 None
 1.27A 6gnrA-2gqiA:
undetectable		 6gnrA-2gqiA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNR_B_6J3B201_0
(TRANSTHYRETIN)		 2gqi RAS
GTPASE-ACTIVATING
PROTEIN 1
(Homo
sapiens) 		4 / 4 LYS A  29
LEU A  14
ALA A  12
LEU A  61
 None
 1.26A 6gnrB-2gqiA:
undetectable		 6gnrB-2gqiA:
21.74