SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gr8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2gr8 ADHESIN
(Haemophilus
influenzae) 		5 / 12 GLN A1058
THR A1028
ALA A1031
GLY A1060
SER A1084
 None
 1.03A 1rjdA-2gr8A:
undetectable		 1rjdA-2gr8A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2gr8 ADHESIN
(Haemophilus
influenzae) 		5 / 12 GLN A1058
THR A1028
ALA A1031
GLY A1060
SER A1084
 None
 1.06A 1rjdB-2gr8A:
undetectable		 1rjdB-2gr8A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_0
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 2gr8 ADHESIN
(Haemophilus
influenzae) 		5 / 12 GLN A1058
THR A1028
ALA A1031
GLY A1060
SER A1084
 None
 1.05A 1rjdC-2gr8A:
undetectable		 1rjdC-2gr8A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_2
(HIV-1 PROTEASE)		 2gr8 ADHESIN
(Haemophilus
influenzae) 		4 / 8 ASN A1083
GLY A1027
ALA A1026
ASP A1025
 None
 0.76A 4eyrB-2gr8A:
undetectable		 4eyrB-2gr8A:
24.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQY_B_017B101_2
(PROTEASE E35D-DRV)		 2gr8 ADHESIN
(Haemophilus
influenzae) 		4 / 7 ASN A1083
GLY A1027
ALA A1026
ASP A1025
 None
 0.70A 5kqyB-2gr8A:
undetectable		 5kqyB-2gr8A:
24.30