SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gr9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		5 / 12 LEU A 153
LEU A  15
PHE A   5
VAL A  65
ALA A  69
 None
 1.16A 1n5xA-2gr9A:
undetectable		 1n5xA-2gr9A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		5 / 12 LEU A 153
LEU A  15
PHE A   5
VAL A  65
ALA A  69
 None
 1.16A 1n5xB-2gr9A:
undetectable		 1n5xB-2gr9A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q9R_A_BEZA203_0
(PROTEIN OF UNKNOWN
FUNCTION)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		4 / 5 LEU A  68
GLY A   7
ILE A  74
ILE A  75
 None
 0.79A 2q9rA-2gr9A:
undetectable		 2q9rA-2gr9A:
25.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FPJ_B_SAMB301_1
(PUTATIVE
UNCHARACTERIZED
PROTEIN)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		4 / 7 GLY A 177
GLY A 175
THR A 124
ALA A 179
 None
 0.87A 3fpjB-2gr9A:
5.6		 3fpjB-2gr9A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8I_A_RO7A1_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR ALPHA)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		4 / 7 LEU A 153
VAL A   3
LEU A 148
LEU A 108
 None
 0.80A 3g8iA-2gr9A:
undetectable		 3g8iA-2gr9A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_2
(CANDIDAPEPSIN-2)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		4 / 6 THR A  59
ILE A  75
ASP A  85
THR A  53
 None
 1.10A 3q70A-2gr9A:
undetectable		 3q70A-2gr9A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		5 / 6 GLY A   4
VAL A  60
HIS A  90
SER A  63
THR A  59
 None
 1.25A 3tj7A-2gr9A:
undetectable
3tj7B-2gr9A:
undetectable		 3tj7A-2gr9A:
19.64
3tj7B-2gr9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		5 / 6 GLY A   4
VAL A  60
HIS A  90
SER A  63
THR A  59
 None
 1.26A 3tj7C-2gr9A:
undetectable
3tj7D-2gr9A:
undetectable		 3tj7C-2gr9A:
19.64
3tj7D-2gr9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		5 / 6 VAL A  60
HIS A  90
SER A  63
THR A  59
GLY A   4
 None
 1.28A 3tj7C-2gr9A:
undetectable
3tj7D-2gr9A:
undetectable		 3tj7C-2gr9A:
19.64
3tj7D-2gr9A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z7F_C_FOLC201_0
(FOLATE ECF
TRANSPORTER)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		5 / 12 SER A  63
ALA A  12
PHE A  19
THR A  20
LEU A 153
 None
 1.49A 4z7fC-2gr9A:
undetectable		 4z7fC-2gr9A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_A_RBFA201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 LYS A  57
LEU A  68
ILE A  86
 None
 0.76A 5kc4A-2gr9A:
undetectable		 5kc4A-2gr9A:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 PHE A 182
ASP A 186
LEU A 253
 None
 0.78A 5uhbC-2gr9A:
undetectable		 5uhbC-2gr9A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 PHE A 182
ASP A 186
LEU A 253
 None
 0.71A 5uhcC-2gr9A:
undetectable		 5uhcC-2gr9A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_E_GBME2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 LEU A 185
THR A 124
ASN A 123
 None
 0.62A 6baaE-2gr9A:
undetectable		 6baaE-2gr9A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_F_GBMF2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 LEU A 185
THR A 124
ASN A 123
 None
 0.63A 6baaF-2gr9A:
undetectable		 6baaF-2gr9A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_G_GBMG2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 LEU A 185
THR A 124
ASN A 123
 None
 0.63A 6baaG-2gr9A:
undetectable		 6baaG-2gr9A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BAA_H_GBMH2001_2
(ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		3 / 3 LEU A 185
THR A 124
ASN A 123
 None
 0.63A 6baaH-2gr9A:
undetectable		 6baaH-2gr9A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NJ9_K_SAMK500_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2gr9 PYRROLINE-5-CARBOXYL
ATE REDUCTASE 1
(Homo
sapiens) 		5 / 12 GLY A  18
VAL A   3
ALA A  44
ASP A  38
PHE A  67
 None
 1.07A 6nj9K-2gr9A:
3.2		 6nj9K-2gr9A:
21.45