SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gre'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_A_BEZA881_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 11 LEU A  88
GLY A  74
ILE A 118
HIS A 184
VAL A  99
 None
 1.15A 1tmxA-2greA:
undetectable		 1tmxA-2greA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 12 LEU A  88
GLY A  74
ILE A 118
HIS A 184
VAL A  99
 None
 1.36A 1tmxB-2greA:
undetectable		 1tmxB-2greA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		4 / 8 VAL A 191
VAL A  70
LEU A 194
ASP A  71
 None
 0.94A 2ddwA-2greA:
undetectable		 2ddwA-2greA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		4 / 7 LEU A 337
PRO A 209
GLU A 236
ARG A  64
 None
 1.07A 2jn3A-2greA:
undetectable		 2jn3A-2greA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_B_DSFB319_1
(GLR4197 PROTEIN)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 9 TYR A 114
ILE A 145
ILE A 106
VAL A 155
ILE A  80
 None
 1.26A 3p4wB-2greA:
undetectable		 3p4wB-2greA:
23.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_C_SUEC1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		4 / 5 TYR A 103
ILE A  12
LEU A  15
LYS A  13
 None
 1.21A 3sueC-2greA:
1.9		 3sueC-2greA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WXO_A_NIZA802_1
(CATALASE-PEROXIDASE)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		4 / 8 LEU A 197
ILE A 193
GLY A 314
ILE A 313
 None
 0.84A 3wxoA-2greA:
undetectable		 3wxoA-2greA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_B_SAMB1281_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 12 ASP A 289
GLY A 243
GLY A 314
SER A 257
GLY A 246
 None
 1.02A 4blvB-2greA:
undetectable		 4blvB-2greA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OJB_A_198A1001_2
(ANDROGEN RECEPTOR)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		4 / 7 LEU A  15
ILE A 174
ILE A 180
VAL A 172
 None
 0.78A 4ojbA-2greA:
undetectable		 4ojbA-2greA:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 11 THR A 334
SER A 190
GLY A 316
THR A 326
ASP A 186
 None
 1.31A 4qvnH-2greA:
undetectable
4qvnI-2greA:
undetectable		 4qvnH-2greA:
20.22
4qvnI-2greA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 10 THR A 334
SER A 190
GLY A 316
THR A 326
ASP A 186
 None
 1.31A 4qvnV-2greA:
undetectable
4qvnW-2greA:
undetectable		 4qvnV-2greA:
20.22
4qvnW-2greA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 11 THR A 334
SER A 190
GLY A 316
THR A 326
ASP A 186
 None
 1.31A 4qvqH-2greA:
undetectable
4qvqI-2greA:
undetectable		 4qvqH-2greA:
20.22
4qvqI-2greA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 11 THR A 334
SER A 190
GLY A 316
THR A 326
ASP A 186
 None
 1.31A 4qvqV-2greA:
undetectable
4qvqW-2greA:
undetectable		 4qvqV-2greA:
20.22
4qvqW-2greA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 11 THR A 334
SER A 190
GLY A 316
THR A 326
ASP A 186
 None
 1.33A 4qwuH-2greA:
undetectable
4qwuI-2greA:
undetectable		 4qwuH-2greA:
20.22
4qwuI-2greA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 11 THR A 334
SER A 190
GLY A 316
THR A 326
ASP A 186
 None
 1.32A 4qwuV-2greA:
undetectable
4qwuW-2greA:
undetectable		 4qwuV-2greA:
20.22
4qwuW-2greA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_A_HISA302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 10 GLY A 163
VAL A 162
GLU A 161
THR A 108
VAL A  77
 None
 1.27A 4yb6A-2greA:
undetectable
4yb6E-2greA:
undetectable		 4yb6A-2greA:
22.41
4yb6E-2greA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_B_HISB302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 10 GLY A 163
VAL A 162
GLU A 161
THR A 108
VAL A  77
 None
 1.28A 4yb6B-2greA:
undetectable
4yb6C-2greA:
undetectable		 4yb6B-2greA:
22.41
4yb6C-2greA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YB6_F_HISF302_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 10 GLY A 163
VAL A 162
GLU A 161
THR A 108
VAL A  77
 None
 1.26A 4yb6B-2greA:
undetectable
4yb6F-2greA:
undetectable		 4yb6B-2greA:
22.41
4yb6F-2greA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 11 LEU A 201
LEU A 278
LEU A 238
LEU A  66
LEU A 275
 None
 1.00A 4zowA-2greA:
undetectable		 4zowA-2greA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		4 / 5 SER A 329
ALA A 332
HIS A 327
MET A   9
 None
 1.19A 5dzkb-2greA:
undetectable
5dzkp-2greA:
undetectable		 5dzkb-2greA:
20.80
5dzkp-2greA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		4 / 6 SER A 329
ALA A 332
HIS A 327
MET A   9
 None
 1.20A 5dzkB-2greA:
undetectable
5dzkP-2greA:
undetectable		 5dzkB-2greA:
20.80
5dzkP-2greA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_Q_BEZQ801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		4 / 5 SER A 329
ALA A 332
HIS A 327
MET A   9
 None
 1.20A 5dzkc-2greA:
undetectable
5dzkq-2greA:
undetectable		 5dzkc-2greA:
20.80
5dzkq-2greA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		4 / 5 SER A 329
ALA A 332
HIS A 327
MET A   9
 None
 1.19A 5dzkf-2greA:
undetectable
5dzkt-2greA:
undetectable		 5dzkf-2greA:
20.80
5dzkt-2greA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_U_BEZU801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		4 / 6 SER A 329
ALA A 332
HIS A 327
MET A   9
 None
 1.20A 5dzkg-2greA:
undetectable
5dzku-2greA:
undetectable		 5dzkg-2greA:
20.80
5dzku-2greA:
3.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA303_1
(CHITOSANASE)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		4 / 5 HIS A 327
VAL A 189
GLY A 316
ALA A 315
 None
 0.94A 5hwaA-2greA:
undetectable		 5hwaA-2greA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 12 THR A 334
SER A 190
GLY A 316
THR A 326
ASP A 186
 None
 1.33A 5l5zH-2greA:
undetectable
5l5zI-2greA:
undetectable		 5l5zH-2greA:
20.22
5l5zI-2greA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 12 THR A 334
SER A 190
GLY A 316
THR A 326
ASP A 186
 None
 1.33A 5l5zV-2greA:
undetectable
5l5zW-2greA:
undetectable		 5l5zV-2greA:
20.22
5l5zW-2greA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 10 ASP A 169
GLU A 102
LEU A  15
SER A 182
GLY A  74
 None
 1.17A 5m5cE-2greA:
undetectable		 5m5cE-2greA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIO_A_HFGA801_0
(PROLINE-TRNA
SYNTHETASE CLASS II
AARS (YBAK RNA
BINDING DOMAIN PLUS
TRNA SYNTHETASE))		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 12 GLU A 236
VAL A 308
THR A 334
SER A 190
GLY A 314
 None
 1.35A 5xioA-2greA:
undetectable		 5xioA-2greA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_A_ZOTA3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 2gre DEBLOCKING
AMINOPEPTIDASE
(Bacillus
cereus) 		5 / 12 SER A  98
LEU A  88
VAL A 143
PHE A 323
PHE A 168
 None
 1.43A 6a94A-2greA:
undetectable		 6a94A-2greA:
22.58