SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2grk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_B_BEZB504_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 2grk EVM001
(Ectromelia
virus) 		4 / 7 LEU A 221
ILE A  27
PHE A 184
ILE A 168
 None
 0.90A 1oniB-2grkA:
undetectable
1oniC-2grkA:
undetectable		 1oniB-2grkA:
21.49
1oniC-2grkA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 2grk EVM001
(Ectromelia
virus) 		3 / 3 ARG A 164
VAL A 186
GLY A 170
 None
 0.52A 2avvE-2grkA:
undetectable		 2avvE-2grkA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IK6_B_HCZB800_1
(GLUTAMATE RECEPTOR 2)		 2grk EVM001
(Ectromelia
virus) 		5 / 10 SER A 116
ILE A  24
PRO A  87
SER A 109
GLY A  23
 None
 1.28A 3ik6B-2grkA:
undetectable
3ik6E-2grkA:
undetectable		 3ik6B-2grkA:
22.01
3ik6E-2grkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_B_HFZB800_1
(GLUTAMATE RECEPTOR 2)		 2grk EVM001
(Ectromelia
virus) 		5 / 10 SER A 116
ILE A  24
PRO A  87
SER A 109
GLY A  23
 None
 1.38A 3iluB-2grkA:
undetectable
3iluE-2grkA:
undetectable		 3iluB-2grkA:
22.01
3iluE-2grkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ILU_E_HFZE800_1
(GLUTAMATE RECEPTOR 2)		 2grk EVM001
(Ectromelia
virus) 		5 / 11 ILE A  24
PRO A  87
SER A 109
GLY A  23
SER A 116
 None
 1.39A 3iluB-2grkA:
undetectable
3iluE-2grkA:
undetectable		 3iluB-2grkA:
22.01
3iluE-2grkA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 2grk EVM001
(Ectromelia
virus) 		4 / 8 ASP A  25
SER A  91
SER A  93
TYR A 112
 None
 1.03A 3rodA-2grkA:
undetectable		 3rodA-2grkA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 2grk EVM001
(Ectromelia
virus) 		3 / 3 ILE A  28
ILE A 169
MET A  79
 None
 0.60A 5i9yA-2grkA:
undetectable		 5i9yA-2grkA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_A_CYZA1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 2grk EVM001
(Ectromelia
virus) 		5 / 10 SER A 116
ILE A  24
PRO A  87
SER A 109
GLY A  23
 None
 1.42A 5weoA-2grkA:
undetectable
5weoD-2grkA:
0.0		 5weoA-2grkA:
13.00
5weoD-2grkA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_B_CYZB1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 2grk EVM001
(Ectromelia
virus) 		5 / 9 SER A 116
ILE A  24
PRO A  87
SER A 109
GLY A  23
 None
 1.41A 5weoB-2grkA:
undetectable
5weoC-2grkA:
0.0		 5weoB-2grkA:
13.00
5weoC-2grkA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEO_D_CYZD1302_1
(GLUTAMATE RECEPTOR
2,VOLTAGE-DEPENDENT
CALCIUM CHANNEL
GAMMA-2 SUBUNIT
CHIMERA)		 2grk EVM001
(Ectromelia
virus) 		5 / 9 ILE A  24
PRO A  87
SER A 109
GLY A  23
SER A 116
 None
 1.42A 5weoA-2grkA:
0.0
5weoD-2grkA:
0.0		 5weoA-2grkA:
13.00
5weoD-2grkA:
13.00