SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2grm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_A_RTLA401_0
(RETINOL DEHYDRATASE)		 2grm PRGX
(Enterococcus
faecalis) 		5 / 12 TYR A 176
LEU A 239
LEU A 160
TYR A 165
ILE A 200
 None
 1.34A 1fmlA-2grmA:
undetectable		 1fmlA-2grmA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MRQ_A_STRA501_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C1)		 2grm PRGX
(Enterococcus
faecalis) 		5 / 11 LEU A 159
VAL A 168
ILE A 171
LEU A 107
LEU A 141
 None
 1.34A 1mrqA-2grmA:
undetectable		 1mrqA-2grmA:
23.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_1
(BILE ACID RECEPTOR)		 2grm PRGX
(Enterococcus
faecalis) 		5 / 12 LEU A 163
ILE A 155
PHE A 110
ILE A 134
TYR A 113
 None
 1.43A 1osvB-2grmA:
undetectable		 1osvB-2grmA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OT7_B_IU5B1002_1
(BILE ACID RECEPTOR)		 2grm PRGX
(Enterococcus
faecalis) 		5 / 12 LEU A 163
ILE A 155
PHE A 110
ILE A 134
TYR A 113
 None
 1.39A 1ot7B-2grmA:
undetectable		 1ot7B-2grmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SV5_A_65BA600_0
(REVERSE
TRANSCRIPTASE)		 2grm PRGX
(Enterococcus
faecalis) 		5 / 10 LEU A 194
LYS A 195
VAL A 156
TYR A 153
TYR A 213
 None
 1.44A 1sv5A-2grmA:
undetectable		 1sv5A-2grmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z9H_D_IMND476_1
(MEMBRANE-ASSOCIATED
PROSTAGLANDIN E
SYNTHASE-2)		 2grm PRGX
(Enterococcus
faecalis) 		5 / 12 ILE A 172
VAL A 193
TYR A 153
ILE A 178
LEU A 194
 None
 1.23A 1z9hD-2grmA:
3.0		 1z9hD-2grmA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_F_TACF3888_1
(ELONGATION FACTOR
EF-TU)		 2grm PRGX
(Enterococcus
faecalis) 		4 / 7 THR A 247
ASP A 248
SER A 253
LEU A 198
 None
 1.05A 2hdnE-2grmA:
undetectable
2hdnF-2grmA:
undetectable
2hdnH-2grmA:
undetectable		 2hdnE-2grmA:
12.02
2hdnF-2grmA:
19.61
2hdnH-2grmA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_H_TACH4888_1
(ELONGATION FACTOR
EF-TU)		 2grm PRGX
(Enterococcus
faecalis) 		4 / 7 SER A 253
LEU A 198
THR A 247
ASP A 248
 None
 1.04A 2hdnF-2grmA:
undetectable
2hdnG-2grmA:
undetectable
2hdnH-2grmA:
undetectable		 2hdnF-2grmA:
19.61
2hdnG-2grmA:
12.02
2hdnH-2grmA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QBM_A_CAMA517_0
(CYTOCHROME P450-CAM)		 2grm PRGX
(Enterococcus
faecalis) 		4 / 8 TYR A 254
VAL A 295
THR A 296
ILE A 283
 None
 0.89A 2qbmA-2grmA:
undetectable		 2qbmA-2grmA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZD1_A_T27A557_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2grm PRGX
(Enterococcus
faecalis) 		5 / 12 LEU A 276
VAL A 295
TYR A 299
PRO A 291
TYR A 238
 None
 1.49A 2zd1A-2grmA:
0.0		 2zd1A-2grmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_E_VD3E2001_1
(VITAMIN D
HYDROXYLASE)		 2grm PRGX
(Enterococcus
faecalis) 		5 / 12 ILE A 261
LEU A 239
ASN A 196
LEU A 280
ILE A 242
 None
 1.25A 3a50E-2grmA:
3.0		 3a50E-2grmA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BRF_A_SORA1_0
(LIN-12 AND GLP-1
PHENOTYPE PROTEIN 1,
ISOFORM A)		 2grm PRGX
(Enterococcus
faecalis) 		3 / 3 GLY A 183
ASP A 187
SER A 227
 None
 0.68A 3brfA-2grmA:
undetectable		 3brfA-2grmA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS202_1
(PROTEIN S100-A4)		 2grm PRGX
(Enterococcus
faecalis) 		4 / 6 LEU A   8
SER A  51
PHE A  50
ILE A  42
 None
 0.94A 3ko0S-2grmA:
0.0		 3ko0S-2grmA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 2grm PRGX
(Enterococcus
faecalis) 		3 / 3 TYR A 109
LEU A 163
ARG A 103
 None
 0.74A 3sufB-2grmA:
undetectable		 3sufB-2grmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 2grm PRGX
(Enterococcus
faecalis) 		4 / 5 GLY A 115
TYR A 109
TYR A 116
GLU A  78
 None
 1.19A 4ae1B-2grmA:
undetectable		 4ae1B-2grmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B3Q_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2grm PRGX
(Enterococcus
faecalis) 		4 / 7 LEU A 194
VAL A 156
TYR A 153
TYR A 213
 None
 1.14A 4b3qA-2grmA:
undetectable		 4b3qA-2grmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 2grm PRGX
(Enterococcus
faecalis) 		3 / 3 ASN A  88
PHE A  86
TYR A 116
 None
 0.84A 4u15A-2grmA:
undetectable		 4u15A-2grmA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1R_A_STRA600_1
(CYTOCHROME P450 3A4)		 2grm PRGX
(Enterococcus
faecalis) 		4 / 5 PHE A  96
ASP A  93
PHE A  92
VAL A 127
 None
 0.88A 5a1rA-2grmA:
undetectable		 5a1rA-2grmA:
23.24