SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gry'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MT1_A_AG2A7005_1
(PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE BETA
CHAIN
PYRUVOYL-DEPENDENT
ARGININE
DECARBOXYLASE ALPHA
CHAIN)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		4 / 6 LEU A 314
ASP A 318
LEU A 321
GLU A 260
 None
 1.10A 1mt1A-2gryA:
undetectable
1mt1F-2gryA:
undetectable		 1mt1A-2gryA:
8.29
1mt1F-2gryA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_A_RBFA191_1
(LUMAZINE PROTEIN)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		5 / 12 VAL A 411
SER A 427
LEU A 428
THR A 273
ILE A 274
 None
 1.06A 3a35A-2gryA:
undetectable		 3a35A-2gryA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A35_B_RBFB191_1
(LUMAZINE PROTEIN)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		5 / 12 VAL A 411
SER A 427
LEU A 428
THR A 273
ILE A 274
 None
 1.10A 3a35B-2gryA:
undetectable		 3a35B-2gryA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3B_A_RBFA191_1
(LUMAZINE PROTEIN)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		5 / 12 VAL A 411
SER A 427
LEU A 428
THR A 273
ILE A 274
 None
 1.01A 3a3bA-2gryA:
undetectable		 3a3bA-2gryA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E9R_C_ACTC700_0
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		4 / 6 GLY A 286
TYR A 519
MET A 499
ASN A 434
 UNX  A2002 (-3.6A)
None
None
UNX  A2002 ( 4.5A)
 0.98A 3e9rC-2gryA:
undetectable		 3e9rC-2gryA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HUO_A_PNNA302_0
(CTX-M-9
EXTENDED-SPECTRUM
BETA-LACTAMASE)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		5 / 6 THR A 220
ARG A 178
LEU A 181
GLY A 179
PRO A 222
 None
 1.49A 3huoA-2gryA:
undetectable		 3huoA-2gryA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JUS_B_ECNB602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		5 / 9 LEU A 314
TYR A 312
PHE A 339
ALA A 284
THR A 502
 None
 1.45A 3jusB-2gryA:
undetectable		 3jusB-2gryA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OYA_A_RLTA398_1
(PFV INTEGRASE)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		4 / 8 ASP A 254
PRO A 222
TYR A 183
PRO A 185
 None
 1.11A 3oyaA-2gryA:
undetectable		 3oyaA-2gryA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_B_ACTB4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		3 / 3 GLY A 289
GLY A 291
THR A 293
 ADP  A 601 (-3.5A)
ADP  A 601 (-3.1A)
MG  A 701 ( 3.2A)
 0.42A 3si7B-2gryA:
undetectable		 3si7B-2gryA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JEC_B_478B401_3
(HIV-1 PROTEASE)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		3 / 3 ASP A 430
LEU A 350
VAL A 383
 MG  A 701 ( 4.0A)
None
None
 0.70A 4jecB-2gryA:
undetectable		 4jecB-2gryA:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		4 / 5 ILE A 274
VAL A 271
PHE A 265
CYH A 282
 None
 1.36A 4rzvA-2gryA:
undetectable		 4rzvA-2gryA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_A_SAMA1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		5 / 12 TYR A 285
SER A 427
ALA A 315
ALA A 267
TYR A 263
 None
 1.39A 4ymgA-2gryA:
undetectable		 4ymgA-2gryA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YMG_B_SAMB1001_0
(PUTATIVE
SAM-DEPENDENT
O-METHYLTRANFERASE)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		5 / 12 TYR A 285
SER A 427
ALA A 315
ALA A 267
TYR A 263
 None
 1.38A 4ymgB-2gryA:
undetectable		 4ymgB-2gryA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA411_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2gry KINESIN-LIKE PROTEIN
KIF2
(Homo
sapiens) 		3 / 3 LYS A 425
LEU A 422
ARG A 417
 None
 0.86A 5yw0A-2gryA:
undetectable		 5yw0A-2gryA:
21.77