SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gs8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQG_B_IBPB1701_1
(PROSTAGLANDIN H2
SYNTHASE-1)		 2gs8 MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Streptococcus
pyogenes) 		5 / 11 VAL A  90
SER A  49
ILE A   6
ALA A 117
LEU A 114
 None
 1.14A 1eqgB-2gs8A:
undetectable		 1eqgB-2gs8A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 2gs8 MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Streptococcus
pyogenes) 		4 / 8 ILE A  79
ILE A  75
THR A  46
THR A  94
 None
 0.71A 1sbrA-2gs8A:
undetectable		 1sbrA-2gs8A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TDR_A_MTXA170_1
(TELLUROMETHIONYL
DIHYDROFOLATE
REDUCTASE)		 2gs8 MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Streptococcus
pyogenes) 		5 / 12 ALA A 270
LEU A 167
THR A 229
ILE A  16
LEU A  37
 None
 1.18A 1tdrA-2gs8A:
undetectable		 1tdrA-2gs8A:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 2gs8 MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Streptococcus
pyogenes) 		3 / 3 ASP A 194
GLU A  23
TYR A  19
 None
None
EDO  A 509 (-4.6A)
 0.83A 1wsvA-2gs8A:
0.9		 1wsvA-2gs8A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_D_CGED501_1
(CYTOCHROME P450 2B4)		 2gs8 MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Streptococcus
pyogenes) 		5 / 9 VAL A 225
PHE A 222
ILE A  16
ALA A 170
VAL A 150
 None
 1.02A 3me6D-2gs8A:
undetectable		 3me6D-2gs8A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 2gs8 MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Streptococcus
pyogenes) 		4 / 4 ASN A  13
LEU A 217
PHE A 147
TYR A 161
 None
 1.34A 4u14A-2gs8A:
0.0		 4u14A-2gs8A:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2gs8 MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Streptococcus
pyogenes) 		5 / 9 SER A  33
ALA A 152
ALA A 151
GLY A 158
ALA A 159
 None
 1.08A 5d0xK-2gs8A:
undetectable
5d0xL-2gs8A:
undetectable		 5d0xK-2gs8A:
20.31
5d0xL-2gs8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 2gs8 MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Streptococcus
pyogenes) 		5 / 9 SER A  33
ALA A 152
ALA A 151
GLY A 158
ALA A 159
 None
 1.08A 5d0xY-2gs8A:
undetectable
5d0xZ-2gs8A:
undetectable		 5d0xY-2gs8A:
20.31
5d0xZ-2gs8A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 2gs8 MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE
(Streptococcus
pyogenes) 		4 / 8 SER A 142
THR A  94
THR A  44
SER A  10
 None
None
None
EDO  A 502 (-3.8A)
 0.96A 5l4eA-2gs8A:
1.6
5l4eB-2gs8A:
undetectable
5l4eC-2gs8A:
1.6
5l4eD-2gs8A:
1.6
5l4eE-2gs8A:
1.6		 5l4eA-2gs8A:
20.00
5l4eB-2gs8A:
20.00
5l4eC-2gs8A:
20.00
5l4eD-2gs8A:
20.00
5l4eE-2gs8A:
20.00