SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gs9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		4 / 8 VAL A 115
VAL A  61
VAL A  63
LEU A  90
 None
 0.66A 1igxA-2gs9A:
undetectable		 1igxA-2gs9A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_C_SAMC2293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 GLY A  47
THR A  48
SER A  66
MET A  69
TYR A  15
 SAH  A 301 (-3.5A)
None
SAH  A 301 (-4.5A)
SAH  A 301 (-4.2A)
None
 1.28A 1nbiC-2gs9A:
13.6		 1nbiC-2gs9A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NBI_D_SAMD3293_0
(GLYCINE
N-METHYLTRANSFERASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 GLY A  47
THR A  48
SER A  66
MET A  69
TYR A  15
 SAH  A 301 (-3.5A)
None
SAH  A 301 (-4.5A)
SAH  A 301 (-4.2A)
None
 1.31A 1nbiD-2gs9A:
13.7		 1nbiD-2gs9A:
25.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		4 / 8 ARG A 203
GLU A 164
LEU A 134
VAL A 133
 None
 0.79A 2bxgA-2gs9A:
undetectable		 2bxgA-2gs9A:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QD4_B_CHDB927_0
(FERROCHELATASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		3 / 3 LEU A  55
PRO A  56
ARG A 210
 None
 0.60A 2qd4B-2gs9A:
undetectable		 2qd4B-2gs9A:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XYT_H_TC9H1206_1
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		4 / 7 TRP A 140
TYR A 190
GLU A 191
TYR A  22
 None
 1.49A 2xytH-2gs9A:
undetectable		 2xytH-2gs9A:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DH0_A_SAMA220_0
(SAM DEPENDENT
METHYLTRANSFERASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 VAL A  44
GLY A  45
GLY A  47
PHE A 103
THR A 105
 None
SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.5A)
SAH  A 301 (-3.5A)
 0.81A 3dh0A-2gs9A:
17.5		 3dh0A-2gs9A:
23.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_1
(DIHYDROFOLATE
REDUCTASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 LEU A 134
GLU A  26
SER A 138
PRO A 204
LEU A 182
 None
 1.19A 3eigA-2gs9A:
2.6		 3eigA-2gs9A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_A_TOPA200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 10 LEU A 206
GLU A 107
ALA A  30
LEU A 101
TYR A  15
 None
 1.22A 3fl9A-2gs9A:
undetectable		 3fl9A-2gs9A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 GLY A  45
GLY A  47
PRO A  65
GLU A  88
PHE A 103
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.2A)
SAH  A 301 (-2.9A)
SAH  A 301 (-4.5A)
 0.85A 3mteB-2gs9A:
9.1		 3mteB-2gs9A:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 TYR A  11
GLU A  43
TRP A  51
SER A  66
MET A  69
 None
SAH  A 301 (-3.8A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.5A)
SAH  A 301 (-4.2A)
 0.85A 3ou6D-2gs9A:
16.0		 3ou6D-2gs9A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 TYR A  11
GLY A  47
TRP A  51
SER A  66
MET A  69
 None
SAH  A 301 (-3.5A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.5A)
SAH  A 301 (-4.2A)
 0.72A 3ou7A-2gs9A:
15.9		 3ou7A-2gs9A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 TYR A  11
GLY A  47
TRP A  51
SER A  66
MET A  69
 None
SAH  A 301 (-3.5A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.5A)
SAH  A 301 (-4.2A)
 0.71A 3ou7B-2gs9A:
15.9		 3ou7B-2gs9A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 TYR A  11
GLY A  47
TRP A  51
SER A  66
MET A  69
 None
SAH  A 301 (-3.5A)
SAH  A 301 (-4.6A)
SAH  A 301 (-4.5A)
SAH  A 301 (-4.2A)
 0.69A 3ou7D-2gs9A:
16.0		 3ou7D-2gs9A:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TX2_A_BEZA251_0
(PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		4 / 7 ARG A 145
ALA A 141
TRP A 155
ALA A 136
 None
 1.46A 3tx2A-2gs9A:
undetectable		 3tx2A-2gs9A:
25.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		4 / 8 VAL A 131
LEU A 166
LEU A 170
ASP A 111
 None
 0.87A 4lzrA-2gs9A:
undetectable		 4lzrA-2gs9A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_0
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 PHE A   4
GLY A  45
GLY A  47
SER A  66
MET A  69
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.5A)
SAH  A 301 (-4.2A)
 0.35A 4qdjA-2gs9A:
16.4		 4qdjA-2gs9A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QTU_D_SAMD301_0
(PUTATIVE
METHYLTRANSFERASE
BUD23)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 TYR A  11
GLY A  45
GLY A  47
SER A  66
MET A  69
 None
SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.5A)
SAH  A 301 (-4.2A)
 0.41A 4qtuD-2gs9A:
15.0		 4qtuD-2gs9A:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_C_SAMC301_0
(UNCHARACTERIZED
PROTEIN)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 ARG A  76
ALA A  77
GLY A  62
ALA A  68
GLU A  12
 None
 1.11A 4r29C-2gs9A:
undetectable		 4r29C-2gs9A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TWD_F_377F402_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		4 / 8 ALA A 193
ALA A 183
ALA A 200
ALA A 196
 None
 0.80A 4twdF-2gs9A:
undetectable
4twdG-2gs9A:
undetectable
4twdH-2gs9A:
undetectable
4twdI-2gs9A:
undetectable
4twdJ-2gs9A:
undetectable		 4twdF-2gs9A:
21.97
4twdG-2gs9A:
21.97
4twdH-2gs9A:
21.97
4twdI-2gs9A:
21.97
4twdJ-2gs9A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_F_CHDF103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 11 ARG A  29
LEU A 208
GLU A 135
ALA A 205
LEU A 206
 None
 1.01A 4wg0F-2gs9A:
undetectable
4wg0G-2gs9A:
undetectable
4wg0H-2gs9A:
undetectable		 4wg0F-2gs9A:
3.32
4wg0G-2gs9A:
3.32
4wg0H-2gs9A:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WG0_M_CHDM103_0
(NUCLEAR RECEPTOR
COACTIVATOR 2)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 11 GLU A 135
ALA A 205
LEU A 206
LEU A 208
ARG A  29
 None
 1.06A 4wg0K-2gs9A:
undetectable
4wg0L-2gs9A:
undetectable
4wg0M-2gs9A:
undetectable		 4wg0K-2gs9A:
3.32
4wg0L-2gs9A:
3.32
4wg0M-2gs9A:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		3 / 3 LEU A 182
LEU A  19
ARG A 146
 None
 0.60A 5hnzB-2gs9A:
2.7		 5hnzB-2gs9A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 VAL A 109
GLY A  45
ALA A  46
LEU A  55
LEU A  41
 SAH  A 301 (-3.8A)
SAH  A 301 (-3.7A)
None
None
None
 1.29A 5x23A-2gs9A:
undetectable		 5x23A-2gs9A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 12 GLY A  45
GLY A  47
SER A  66
MET A  69
PHE A 103
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.5A)
SAH  A 301 (-4.5A)
SAH  A 301 (-4.2A)
SAH  A 301 (-4.5A)
 1.19A 5yf0A-2gs9A:
13.0		 5yf0A-2gs9A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_A_FJQA501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 10 LEU A 182
VAL A 180
ILE A  24
ALA A  21
THR A  17
 None
 1.22A 6h1lA-2gs9A:
undetectable		 6h1lA-2gs9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H1L_B_FJQB501_0
(BIFUNCTIONAL
CYTOCHROME
P450/NADPH--P450
REDUCTASE)		 2gs9 HYPOTHETICAL PROTEIN
TT1324
(Thermus
thermophilus) 		5 / 11 LEU A 182
VAL A 180
ILE A  24
ALA A  21
THR A  17
 None
 1.18A 6h1lB-2gs9A:
undetectable		 6h1lB-2gs9A:
21.30