SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gsk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		3 / 3 GLU A 108
ILE A 130
ARG A 255
 None
 0.75A 1cd2A-2gskA:
undetectable		 1cd2A-2gskA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVX_B_DIFB125_1
(TRANSTHYRETIN)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 7 ALA A 252
LEU A 254
SER A 263
THR A 267
 HEX  A 807 ( 3.9A)
None
None
HEX  A 807 (-3.4A)
 0.52A 1dvxA-2gskA:
undetectable		 1dvxA-2gskA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTN_K_TRPK81_0
(TRP RNA-BINDING
ATTENUATION PROTEIN)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 7 THR A  40
SER A  60
GLY A 145
THR A 175
 None
None
LDA  A 803 (-4.2A)
None
 0.96A 1gtnJ-2gskA:
undetectable
1gtnK-2gskA:
undetectable		 1gtnJ-2gskA:
7.94
1gtnK-2gskA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IG3_A_VIBA502_1
(THIAMIN
PYROPHOSPHOKINASE)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 8 ASN A 194
GLN A  62
ASP A 230
THR A 242
 None
None
CA  A   1 (-2.1A)
None
 1.10A 1ig3A-2gskA:
undetectable
1ig3B-2gskA:
undetectable		 1ig3A-2gskA:
16.53
1ig3B-2gskA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_D_ADND1504_1
(CLASS B ACID
PHOSPHATASE)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 8 ASP A 278
TYR A 229
THR A 289
TYR A 277
 None
CNC  A 701 ( 3.5A)
CNC  A 701 (-3.4A)
None
 1.04A 1rmtD-2gskA:
undetectable		 1rmtD-2gskA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNI_A_MTKA501_1
(CYTOCHROME P450 2C8)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 12 SER A 415
SER A 392
THR A 370
ASN A 438
THR A 343
 None
 1.10A 2nniA-2gskA:
undetectable		 2nniA-2gskA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AG4_B_CHDB1085_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 12 GLY A 119
GLN A 372
THR A 391
ARG A  19
GLY A 125
 None
 1.36A 3ag4A-2gskA:
undetectable
3ag4B-2gskA:
0.0
3ag4T-2gskA:
0.0		 3ag4A-2gskA:
21.56
3ag4B-2gskA:
14.48
3ag4T-2gskA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_A_SALA257_1
(TRANSCRIPTIONAL
REGULATOR)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 8 ARG A  36
ALA A 550
THR A 519
ILE A 518
 None
 0.91A 3bpxA-2gskA:
undetectable
3bpxB-2gskA:
undetectable		 3bpxA-2gskA:
14.95
3bpxB-2gskA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CL9_A_MTXA602_2
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE (DHFR-TS))		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 4 VAL A 127
ARG A  47
ILE A 101
THR A  27
 None
 1.39A 3cl9A-2gskA:
undetectable		 3cl9A-2gskA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_A_CGEA501_1
(CYTOCHROME P450 2B4)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 10 VAL A  52
ILE A  66
ILE A 129
VAL A 107
VAL A 127
 None
 1.02A 3me6A-2gskA:
undetectable		 3me6A-2gskA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MG0_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 11 SER A 374
THR A 373
GLN A 372
THR A  21
ALA A  24
 None
 1.30A 3mg0H-2gskA:
undetectable
3mg0I-2gskA:
undetectable		 3mg0H-2gskA:
17.03
3mg0I-2gskA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5J_A_08HA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 7 PRO A 412
LEU A 401
LEU A 398
ASN A 362
 None
 0.81A 3u5jA-2gskA:
undetectable		 3u5jA-2gskA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_A_08JA1_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 8 PRO A 412
LEU A 401
LEU A 398
ASN A 362
 None
 0.79A 3u5kA-2gskA:
undetectable		 3u5kA-2gskA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_B_08JB2_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 7 PRO A 412
LEU A 401
LEU A 398
ASN A 362
 None
 0.82A 3u5kB-2gskA:
undetectable		 3u5kB-2gskA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_C_08JC3_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 8 PRO A 412
LEU A 401
LEU A 398
ASN A 362
 None
 0.87A 3u5kC-2gskA:
undetectable		 3u5kC-2gskA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U5K_D_08JD4_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 8 PRO A 412
LEU A 401
LEU A 398
ASN A 362
 None
 0.92A 3u5kD-2gskA:
undetectable		 3u5kD-2gskA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UM5_A_CP6A609_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 10 VAL A  29
ASP A  33
THR A 467
SER A 480
THR A  30
 None
 1.37A 3um5A-2gskA:
undetectable		 3um5A-2gskA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 2gsk VITAMIN B12
TRANSPORTER BTUB
PROTEIN TONB
(Escherichia
coli;
Escherichia
coli) 		3 / 3 THR A  11
VAL A   9
GLU B 173
 None
 0.64A 3v4tA-2gskA:
undetectable
3v4tD-2gskA:
undetectable		 3v4tA-2gskA:
21.84
3v4tD-2gskA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 11 GLY A 119
GLN A 372
THR A 391
ARG A  19
GLY A 125
 None
 1.26A 3x2qA-2gskA:
undetectable
3x2qB-2gskA:
0.0
3x2qT-2gskA:
0.0		 3x2qA-2gskA:
21.56
3x2qB-2gskA:
14.48
3x2qT-2gskA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZT_A_SAMA1472_1
(METHYLTRANSFERASE
WBDD)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		3 / 3 GLN A  62
ASP A 193
GLN A 191
 None
CA  A   2 ( 2.1A)
None
 0.84A 4aztA-2gskA:
undetectable		 4aztA-2gskA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FVQ_A_ACTA904_0
(TYROSINE-PROTEIN
KINASE JAK2)		 2gsk PROTEIN TONB
(Escherichia
coli) 		3 / 3 PHE B 230
VAL B 176
GLU B 203
 None
 0.55A 4fvqA-2gskB:
undetectable		 4fvqA-2gskB:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GC9_A_ACTA402_0
(DIMETHYLADENOSINE
TRANSFERASE 1,
MITOCHONDRIAL)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		3 / 3 LYS A 244
TYR A 275
ARG A 283
 None
 1.10A 4gc9A-2gskA:
undetectable		 4gc9A-2gskA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOU_A_C04A207_1
(UNCHARACTERIZED
PROTEIN)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		3 / 3 GLY A  58
GLU A 574
THR A 575
 None
 0.54A 4kouA-2gskA:
undetectable		 4kouA-2gskA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 8 HIS A 280
PRO A 279
ASP A 278
SER A 234
 None
 1.18A 4kttA-2gskA:
undetectable		 4kttA-2gskA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2gsk PROTEIN TONB
VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 8 ARG B 166
SER A 388
ALA A 421
SER A 434
 None
 1.06A 4lv9A-2gskB:
undetectable
4lv9B-2gskB:
undetectable		 4lv9A-2gskB:
11.11
4lv9B-2gskB:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MS4_A_2C0A501_1
(GAMMA-AMINOBUTYRIC
ACID TYPE B RECEPTOR
SUBUNIT 1)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 8 SER A 392
SER A 415
ILE A 461
GLU A 413
 None
 1.27A 4ms4A-2gskA:
undetectable		 4ms4A-2gskA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 11 GLY A 119
GLN A 372
THR A 391
ARG A  19
GLY A 125
 None
 1.35A 5b1aA-2gskA:
undetectable
5b1aB-2gskA:
0.0
5b1aT-2gskA:
0.0		 5b1aA-2gskA:
21.56
5b1aB-2gskA:
14.48
5b1aT-2gskA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 11 GLY A 119
GLN A 372
THR A 391
ARG A  19
GLY A 125
 None
 1.35A 5b1bA-2gskA:
undetectable
5b1bB-2gskA:
0.0
5b1bT-2gskA:
0.0		 5b1bA-2gskA:
21.56
5b1bB-2gskA:
14.48
5b1bT-2gskA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2S_A_ACTA107_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		3 / 3 VAL A  28
THR A  30
ARG A 106
 None
 0.68A 5b2sB-2gskA:
undetectable		 5b2sB-2gskA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2T_A_ACTA108_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9
GUIDE RNA)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		3 / 3 VAL A  28
THR A  30
ARG A 106
 None
 0.68A 5b2tB-2gskA:
undetectable		 5b2tB-2gskA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 12 SER A 374
THR A 373
GLN A 372
THR A  21
ALA A  24
 None
 1.27A 5d0xH-2gskA:
undetectable
5d0xI-2gskA:
undetectable		 5d0xH-2gskA:
17.38
5d0xI-2gskA:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EF3_L_TRPL101_0
(TRANSCRIPTION
ATTENUATION PROTEIN
MTRB)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 8 THR A  40
SER A  60
GLY A 145
THR A 175
 None
None
LDA  A 803 (-4.2A)
None
 0.98A 5ef3L-2gskA:
undetectable
5ef3V-2gskA:
undetectable		 5ef3L-2gskA:
7.94
5ef3V-2gskA:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_A_TLFA601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		3 / 3 LEU A  85
TYR A 223
SER A 249
 None
 0.89A 5iktA-2gskA:
undetectable		 5iktA-2gskA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		3 / 3 TYR A 296
TYR A 221
SER A 247
 None
 0.96A 5iktB-2gskA:
undetectable		 5iktB-2gskA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		3 / 3 THR A 370
SER A 120
ASP A 361
 None
 0.85A 5kvaA-2gskA:
undetectable		 5kvaA-2gskA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 6 ASP A 316
ARG A  84
ASN A 337
GLN A 295
 None
 1.22A 5l6eA-2gskA:
undetectable		 5l6eA-2gskA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WM2_A_ACTA605_0
(SALICYLATE-AMP
LIGASE)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		3 / 3 THR A  55
THR A 575
ARG A 526
 None
 1.05A 5wm2A-2gskA:
undetectable		 5wm2A-2gskA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_B_CHDB304_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 11 GLY A 119
GLN A 372
THR A 391
ARG A  19
GLY A 125
 None
 1.27A 5xdqA-2gskA:
undetectable
5xdqB-2gskA:
0.0
5xdqT-2gskA:
0.0		 5xdqA-2gskA:
21.56
5xdqB-2gskA:
14.48
5xdqT-2gskA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 11 GLY A 119
GLN A 372
THR A 391
ARG A  19
GLY A 125
 None
 1.31A 5xdxA-2gskA:
undetectable
5xdxB-2gskA:
0.0
5xdxT-2gskA:
0.0		 5xdxA-2gskA:
21.56
5xdxB-2gskA:
14.48
5xdxT-2gskA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y1Y_A_HNQA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 8 PRO A 412
LEU A 401
LEU A 398
ASN A 362
 None
 0.85A 5y1yA-2gskA:
undetectable		 5y1yA-2gskA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 11 GLY A 119
GLN A 372
THR A 391
ARG A  19
GLY A 125
 None
 1.31A 5z84A-2gskA:
undetectable
5z84B-2gskA:
0.0
5z84T-2gskA:
0.0		 5z84A-2gskA:
21.56
5z84B-2gskA:
14.48
5z84T-2gskA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 11 GLY A 119
GLN A 372
THR A 391
ARG A  19
GLY A 125
 None
 1.31A 5z86A-2gskA:
undetectable
5z86B-2gskA:
0.0
5z86T-2gskA:
0.0		 5z86A-2gskA:
21.56
5z86B-2gskA:
14.48
5z86T-2gskA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_B_CHDB302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 11 GLY A 119
GLN A 372
THR A 391
ARG A  19
GLY A 125
 None
 1.29A 5zcoA-2gskA:
undetectable
5zcoB-2gskA:
0.0
5zcoT-2gskA:
0.0		 5zcoA-2gskA:
21.56
5zcoB-2gskA:
14.48
5zcoT-2gskA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 11 GLY A 119
GLN A 372
THR A 391
ARG A  19
GLY A 125
 None
 1.33A 5zcpA-2gskA:
undetectable
5zcpB-2gskA:
0.0
5zcpT-2gskA:
0.0		 5zcpA-2gskA:
21.56
5zcpB-2gskA:
14.48
5zcpT-2gskA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_B_CHDB301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 11 GLY A 119
GLN A 372
THR A 391
ARG A  19
GLY A 125
 None
 1.34A 5zcqA-2gskA:
undetectable
5zcqB-2gskA:
0.0
5zcqT-2gskA:
0.0		 5zcqA-2gskA:
21.56
5zcqB-2gskA:
14.48
5zcqT-2gskA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA609_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		3 / 3 HIS A 176
HIS A 174
ARG A 226
 None
 1.03A 6b58A-2gskA:
undetectable		 6b58A-2gskA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HD6_B_STIB601_1
(TYROSINE-PROTEIN
KINASE ABL1)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		4 / 7 VAL A  22
ILE A 110
GLY A 369
ALA A 356
 None
 0.86A 6hd6B-2gskA:
undetectable		 6hd6B-2gskA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMP_B_CHDB303_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 2
CYTOCHROME C OXIDASE
SUBUNIT 6A2,
MITOCHONDRIAL)		 2gsk VITAMIN B12
TRANSPORTER BTUB
(Escherichia
coli) 		5 / 9 GLY A 119
GLN A 372
THR A 391
ARG A  19
GLY A 125
 None
 1.31A 6nmpA-2gskA:
undetectable
6nmpB-2gskA:
0.0
6nmpT-2gskA:
0.0		 6nmpA-2gskA:
21.56
6nmpB-2gskA:
14.48
6nmpT-2gskA:
10.11