SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gsl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 2gsl HYPOTHETICAL PROTEIN
(Fusobacterium
nucleatum) 		3 / 3 ALA A  50
VAL A  52
TRP A  26
 None
 0.95A 1c4dA-2gslA:
undetectable
1c4dB-2gslA:
undetectable		 1c4dA-2gslA:
8.05
1c4dB-2gslA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_A_DVAA6_0
(GRAMICIDIN A)		 2gsl HYPOTHETICAL PROTEIN
(Fusobacterium
nucleatum) 		3 / 3 ALA A  54
VAL A  52
TRP A  26
 None
 0.99A 1c4dA-2gslA:
undetectable
1c4dB-2gslA:
undetectable		 1c4dA-2gslA:
8.05
1c4dB-2gslA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_B_DVAB6_0
(GRAMICIDIN A)		 2gsl HYPOTHETICAL PROTEIN
(Fusobacterium
nucleatum) 		3 / 3 TRP A  26
ALA A  54
VAL A  52
 None
 0.95A 1c4dA-2gslA:
undetectable
1c4dB-2gslA:
undetectable		 1c4dA-2gslA:
8.05
1c4dB-2gslA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2gsl HYPOTHETICAL PROTEIN
(Fusobacterium
nucleatum) 		3 / 3 ILE A  41
LEU A  44
VAL A  48
 None
 0.48A 1mz9B-2gslA:
undetectable		 1mz9B-2gslA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BU8_A_TF4A1379_1
(PYRUVATE
DEHYDROGENASE KINASE
ISOENZYME 2)		 2gsl HYPOTHETICAL PROTEIN
(Fusobacterium
nucleatum) 		4 / 8 LEU A  68
ILE A 121
ILE A 105
ILE A 106
 None
 0.76A 2bu8A-2gslA:
undetectable		 2bu8A-2gslA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 2gsl HYPOTHETICAL PROTEIN
(Fusobacterium
nucleatum) 		3 / 3 ASP A  23
PHE A  20
LEU A  16
 MG  A 201 (-3.3A)
None
None
 0.74A 2zi9A-2gslA:
undetectable		 2zi9A-2gslA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDI_A_SAMA601_0
(METHYLTRANSFERASE)		 2gsl HYPOTHETICAL PROTEIN
(Fusobacterium
nucleatum) 		5 / 12 PHE A  37
TYR A  39
ILE A  30
ALA A  50
ILE A 126
 None
 1.37A 3ndiA-2gslA:
undetectable		 3ndiA-2gslA:
14.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 2gsl HYPOTHETICAL PROTEIN
(Fusobacterium
nucleatum) 		4 / 7 ASN A 123
LYS A 120
LYS A 119
LEU A  28
 None
 1.21A 4yv5A-2gslA:
undetectable		 4yv5A-2gslA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VW4_A_NCAA403_0
(FERREDOXIN--NADP
REDUCTASE)		 2gsl HYPOTHETICAL PROTEIN
(Fusobacterium
nucleatum) 		5 / 9 GLY A  22
ALA A  24
GLY A 107
LEU A 111
GLU A 115
 None
 1.25A 5vw4A-2gslA:
undetectable		 5vw4A-2gslA:
17.72