SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gsn'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 5 THR A  90
ASP A 210
HIS A 214
HIS A 258
HIS A 363
 ZN  A1000 (-2.4A)
ZN  A1001 (-2.0A)
ZN  A1001 (-3.2A)
ZN  A1000 (-3.2A)
ZN  A1001 (-3.3A)
 0.62A 1ei6A-2gsnA:
28.1		 1ei6A-2gsnA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_C_PPFC413_1
(PHOSPHONOACETATE
HYDROLASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		6 / 8 ASP A  54
THR A  90
ASP A 210
HIS A 214
HIS A 258
HIS A 363
 ZN  A1000 (-2.2A)
ZN  A1000 (-2.4A)
ZN  A1001 (-2.0A)
ZN  A1001 (-3.2A)
ZN  A1000 (-3.2A)
ZN  A1001 (-3.3A)
 0.52A 1ei6C-2gsnA:
28.0		 1ei6C-2gsnA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_D_PPFD412_1
(PHOSPHONOACETATE
HYDROLASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 8 THR A  90
ASP A 210
HIS A 214
HIS A 363
 ZN  A1000 (-2.4A)
ZN  A1001 (-2.0A)
ZN  A1001 (-3.2A)
ZN  A1001 (-3.3A)
 0.54A 1ei6D-2gsnA:
28.0		 1ei6D-2gsnA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N4F_A_ASRA141_0
(LYSOZYME C)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 6 GLY A  64
THR A  66
PRO A  67
SER A  70
 None
 0.47A 1n4fA-2gsnA:
undetectable		 1n4fA-2gsnA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RUK_H_BEZH601_0
(IMMUNOGLOBULIN
IGG2A, HEAVY CHAIN
IMMUNOGLOBULIN
IGG2A, LIGHT CHAIN)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 8 ASN A 111
LEU A  89
GLY A 364
GLY A 286
 None
 0.87A 1rukH-2gsnA:
undetectable
1rukL-2gsnA:
undetectable		 1rukH-2gsnA:
22.56
1rukL-2gsnA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TZ8_B_DESB128_1
(TRANSTHYRETIN)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 11 LEU A  49
LEU A 405
ALA A  47
LEU A 404
THR A 250
 None
 1.27A 1tz8A-2gsnA:
undetectable
1tz8B-2gsnA:
undetectable		 1tz8A-2gsnA:
14.91
1tz8B-2gsnA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXC_B_P1ZB2001_1
(SERUM ALBUMIN)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 9 LEU A 237
LEU A 204
ARG A 172
ALA A 152
ALA A 186
 None
 1.11A 2bxcB-2gsnA:
undetectable		 2bxcB-2gsnA:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH8_A_VIBA1_1
(MAJOR PRION PROTEIN)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 6 PRO A 218
HIS A 216
ASP A 225
TYR A 223
 None
 1.42A 2lh8A-2gsnA:
undetectable		 2lh8A-2gsnA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 8 LEU A  89
LEU A 346
VAL A 263
GLY A 361
 None
 0.97A 2po5B-2gsnA:
undetectable		 2po5B-2gsnA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0G_A_LEUA1887_0
(AMINOACYL-TRNA
SYNTHETASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 8 MET A 260
ASP A 257
TYR A 223
HIS A 214
 None
ZN  A1000 (-2.2A)
None
ZN  A1001 (-3.2A)
 1.21A 2v0gA-2gsnA:
undetectable		 2v0gA-2gsnA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 12 LEU A 204
LEU A  49
VAL A 254
ALA A 186
GLY A 235
 None
 1.20A 2vmyB-2gsnA:
undetectable		 2vmyB-2gsnA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 10 GLY A 361
ALA A 261
HIS A 214
HIS A 363
HIS A 258
 None
None
ZN  A1001 (-3.2A)
ZN  A1001 (-3.3A)
ZN  A1000 (-3.2A)
 1.47A 3boyA-2gsnA:
0.0
3boyC-2gsnA:
0.0		 3boyA-2gsnA:
15.17
3boyC-2gsnA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 10 HIS A 363
HIS A 258
GLY A 361
ALA A 261
HIS A 214
 ZN  A1001 (-3.3A)
ZN  A1000 (-3.2A)
None
None
ZN  A1001 (-3.2A)
 1.46A 3boyA-2gsnA:
0.0
3boyB-2gsnA:
0.0		 3boyA-2gsnA:
15.17
3boyB-2gsnA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOY_A_HISA3001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 10 HIS A 363
HIS A 258
GLY A 361
ALA A 261
HIS A 214
 ZN  A1001 (-3.3A)
ZN  A1000 (-3.2A)
None
None
ZN  A1001 (-3.2A)
 1.45A 3boyB-2gsnA:
0.0
3boyC-2gsnA:
0.0		 3boyB-2gsnA:
15.17
3boyC-2gsnA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_1
(UNCHARACTERIZED
PROTEIN RPA2492)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		3 / 3 TYR A 223
ASP A  59
HIS A 258
 None
None
ZN  A1000 (-3.2A)
 0.86A 3e23A-2gsnA:
undetectable		 3e23A-2gsnA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JB1_A_SAMA1101_0
(STRUCTURAL PROTEIN
VP3)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		6 / 12 GLY A 259
ARG A 373
PRO A  84
ALA A  83
ALA A 261
PRO A 367
 None
 1.27A 3jb1A-2gsnA:
undetectable		 3jb1A-2gsnA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_A_CELA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 6 HIS A  94
SER A 256
LEU A 180
ILE A  51
 None
 0.99A 3kk6A-2gsnA:
undetectable		 3kk6A-2gsnA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 12 ARG A 243
ALA A 239
GLY A 240
MET A 241
ILE A 252
 None
 0.93A 3ku1A-2gsnA:
undetectable		 3ku1A-2gsnA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 12 ARG A 243
ALA A 239
GLY A 240
MET A 241
ILE A 252
 None
 0.81A 3ku1C-2gsnA:
undetectable		 3ku1C-2gsnA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M7R_A_VDXA425_1
(VITAMIN D3 RECEPTOR)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 12 LEU A 180
VAL A 184
SER A 155
VAL A 230
LEU A  69
 None
 1.29A 3m7rA-2gsnA:
undetectable		 3m7rA-2gsnA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1C_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 10 ILE A 269
ASP A 285
ILE A 289
LEU A 346
SER A 362
 None
 1.25A 3o1cA-2gsnA:
undetectable		 3o1cA-2gsnA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O1X_A_ADNA1450_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 10 ILE A 269
ASP A 285
ILE A 289
LEU A 346
SER A 362
 None
 1.25A 3o1xA-2gsnA:
undetectable		 3o1xA-2gsnA:
14.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QGZ_A_ADNA127_1
(HISTIDINE TRIAD
NUCLEOTIDE-BINDING
PROTEIN 1)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 10 ILE A 269
ASP A 285
ILE A 289
LEU A 346
SER A 362
 None
 1.22A 3qgzA-2gsnA:
undetectable		 3qgzA-2gsnA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 7 THR A  90
ASP A 210
HIS A 214
HIS A 363
 ZN  A1000 (-2.4A)
ZN  A1001 (-2.0A)
ZN  A1001 (-3.2A)
ZN  A1001 (-3.3A)
 0.53A 3t01A-2gsnA:
28.2		 3t01A-2gsnA:
25.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_A_RTZA2_1
(CYTOCHROME P450 2D6)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 11 LEU A  49
THR A 250
LEU A 377
VAL A  77
PHE A 376
 None
 1.41A 3tbgA-2gsnA:
undetectable		 3tbgA-2gsnA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_A_ACTA1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 6 ASP A 393
GLY A 414
VAL A 395
THR A 418
 None
 1.23A 3vqrA-2gsnA:
undetectable		 3vqrA-2gsnA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VQR_B_ACTB1002_0
(PUTATIVE
OXIDOREDUCTASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 5 ASP A 393
GLY A 414
VAL A 395
THR A 418
 None
 1.22A 3vqrB-2gsnA:
undetectable		 3vqrB-2gsnA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_D_ADND301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 10 ALA A 233
ARG A 236
GLY A 235
LEU A 238
ILE A  51
 None
 1.13A 3wdmD-2gsnA:
undetectable		 3wdmD-2gsnA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BLV_A_SAMA1281_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 6 HIS A 258
HIS A  94
SER A  52
ASP A  62
 ZN  A1000 (-3.2A)
None
None
None
 1.33A 4blvA-2gsnA:
2.7		 4blvA-2gsnA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_1
(METHYLTRANSFERASE
NSUN4)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		3 / 3 ASP A 244
ARG A 188
ASP A 194
 None
 0.83A 4fp9A-2gsnA:
undetectable		 4fp9A-2gsnA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L4C_B_CAMB502_0
(CAMPHOR
5-MONOOXYGENASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 8 THR A 250
LEU A 191
VAL A 187
ILE A  51
 None
 0.92A 4l4cB-2gsnA:
undetectable		 4l4cB-2gsnA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NQA_A_9CRA501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 11 ALA A 378
LEU A  72
ALA A  73
HIS A  46
LEU A 404
 None
 1.08A 4nqaA-2gsnA:
undetectable		 4nqaA-2gsnA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OR0_B_NPSB603_1
(SERUM ALBUMIN)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 11 LEU A 404
VAL A 397
LEU A 419
LEU A 405
LEU A 423
 None
 1.22A 4or0B-2gsnA:
undetectable		 4or0B-2gsnA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U3E_A_ACTA705_0
(RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 4 HIS A 329
ASP A 104
TYR A 326
VAL A 109
 None
 1.45A 4u3eA-2gsnA:
0.0		 4u3eA-2gsnA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_A_ACTA1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 5 GLY A 213
ALA A 212
GLY A 217
PRO A 218
 None
 0.91A 4u9uA-2gsnA:
undetectable		 4u9uA-2gsnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U9U_B_ACTB1502_0
(NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT F)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 5 GLY A 213
ALA A 212
GLY A 217
PRO A 218
 None
 0.93A 4u9uB-2gsnA:
undetectable		 4u9uB-2gsnA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 4 VAL A 184
ILE A  51
ASN A  68
VAL A 230
 None
 1.08A 5ajqA-2gsnA:
undetectable		 5ajqA-2gsnA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_A_5D5A930_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 12 THR A  90
PHE A  91
PRO A 139
TRP A 154
ARG A 183
 ZN  A1000 (-2.4A)
None
None
None
None
 1.12A 5dlvA-2gsnA:
43.4		 5dlvA-2gsnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 12 ASP A  54
THR A  90
PHE A  91
PRO A 139
TRP A 141
 ZN  A1000 (-2.2A)
ZN  A1000 (-2.4A)
None
None
None
 0.43A 5dlvB-2gsnA:
43.4		 5dlvB-2gsnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DLV_B_5D5B927_0
(ECTONUCLEOTIDE
PYROPHOSPHATASE/PHOS
PHODIESTERASE FAMILY
MEMBER 2)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		6 / 12 THR A  90
PHE A  91
PRO A 139
TRP A 141
TRP A 154
ARG A 183
 ZN  A1000 (-2.4A)
None
None
None
None
None
 1.13A 5dlvB-2gsnA:
43.4		 5dlvB-2gsnA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 12 TYR A 365
PRO A  92
ASP A 210
LEU A 123
HIS A 214
 None
None
ZN  A1001 (-2.0A)
None
ZN  A1001 (-3.2A)
 1.27A 5dv4A-2gsnA:
undetectable		 5dv4A-2gsnA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWZ_D_010D6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
PEDV MAIN PROTEASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		3 / 3 MET A 260
HIS A 214
GLY A 364
 None
ZN  A1001 (-3.2A)
None
 0.85A 5gwzB-2gsnA:
undetectable		 5gwzB-2gsnA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_C_6ZPC902_1
(GLUTAMATE RECEPTOR 2)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 7 SER A 371
PRO A 218
TYR A 223
SER A  88
 None
 1.17A 5l1fC-2gsnA:
undetectable		 5l1fC-2gsnA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4I_B_6J3B201_0
(TRANSTHYRETIN)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 6 LEU A 405
ALA A  47
LEU A 404
THR A 250
 None
 1.18A 5l4iB-2gsnA:
undetectable		 5l4iB-2gsnA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 12 VAL A 209
ASP A 210
LEU A 377
LEU A  69
ARG A 183
 None
ZN  A1001 (-2.0A)
None
None
None
 1.07A 5nd7B-2gsnA:
undetectable		 5nd7B-2gsnA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_SAMA505_0
(CARNOSINE
N-METHYLTRANSFERASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 12 GLY A  55
GLY A 259
SER A  88
MET A 372
TYR A 205
 ZN  A1000 ( 4.9A)
None
None
None
None
 1.46A 5yf0A-2gsnA:
undetectable		 5yf0A-2gsnA:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AF6_A_GLYA507_0
(L-PROLYL-[PEPTIDYL-C
ARRIER PROTEIN]
DEHYDROGENASE)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		3 / 3 TYR A 326
HIS A 110
MET A 113
 None
 1.08A 6af6A-2gsnA:
undetectable		 6af6A-2gsnA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_2
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 5 VAL A 288
THR A 284
LEU A 320
LEU A 306
 None
 0.99A 6bqgA-2gsnA:
undetectable		 6bqgA-2gsnA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_A_QPSA601_2
(-)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		5 / 12 GLU A 160
GLY A 158
TRP A 154
TYR A 205
VAL A  98
 None
 1.34A 6gngA-2gsnA:
undetectable		 6gngA-2gsnA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE
(Xanthomonas
citri) 		4 / 7 GLN A 287
GLY A 364
HIS A 258
SER A 371
 None
None
ZN  A1000 (-3.2A)
None
 0.80A 6hu9S-2gsnA:
undetectable
6hu9q-2gsnA:
undetectable		 6hu9S-2gsnA:
11.24
6hu9q-2gsnA:
14.97