SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gsz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A29_A_TFPA153_1
(CALMODULIN)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 8 ILE A 213
LEU A 206
GLU A 232
ALA A 231
VAL A 237
 None
 1.41A 1a29A-2gszA:
undetectable		 1a29A-2gszA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 ILE A 306
VAL A 237
LEU A 273
LEU A 241
ILE A 253
 None
 1.09A 1kqwA-2gszA:
undetectable		 1kqwA-2gszA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXF_A_DZPA2001_1
(SERUM ALBUMIN)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 ILE A 139
LEU A 122
LEU A 124
VAL A 128
CYH A 132
 None
 1.21A 2bxfA-2gszA:
undetectable		 2bxfA-2gszA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CD2_A_FOLA307_0
(DIHYDROFOLATE
REDUCTASE)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		6 / 12 ALA A 246
ILE A 277
THR A 333
PRO A 125
LEU A 291
THR A 249
 None
 1.36A 2cd2A-2gszA:
undetectable		 2cd2A-2gszA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		4 / 7 ALA A 108
PHE A  48
PRO A  37
THR A  56
 None
 1.06A 2q6oA-2gszA:
2.1		 2q6oA-2gszA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_2
(HIV-1 PROTEASE)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		3 / 3 ARG A 252
VAL A 215
THR A 223
 None
 0.72A 3cyxA-2gszA:
undetectable		 3cyxA-2gszA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 ALA A 227
ALA A 205
VAL A 141
ILE A 139
THR A 240
 None
 1.15A 3czhB-2gszA:
undetectable		 3czhB-2gszA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_H_TOPH200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 9 ALA A 246
LEU A 273
ILE A 297
LEU A 131
THR A 249
 None
 1.35A 3fl9H-2gszA:
undetectable		 3fl9H-2gszA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CD2_A_FOLA207_0
(DIHYDROFOLATE
REDUCTASE)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 ALA A 246
ILE A 277
THR A 333
LEU A 291
THR A 249
 None
 1.20A 4cd2A-2gszA:
undetectable		 4cd2A-2gszA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KSZ_A_CYSA620_0
(LACTOPEROXIDASE)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		3 / 3 ARG A 229
GLU A 225
PHE A 257
 None
 0.71A 4kszA-2gszA:
undetectable		 4kszA-2gszA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 ALA A 230
LEU A 269
GLY A 216
MET A 218
LEU A 241
 None
 1.21A 4kykA-2gszA:
undetectable
4kykB-2gszA:
undetectable		 4kykA-2gszA:
18.13
4kykB-2gszA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYK_B_IMNB300_1
(LACTOYLGLUTATHIONE
LYASE)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 12 ALA A 230
LEU A 273
GLY A 216
MET A 218
LEU A 241
 None
 1.15A 4kykA-2gszA:
undetectable
4kykB-2gszA:
undetectable		 4kykA-2gszA:
18.13
4kykB-2gszA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1X_A_STRA402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		4 / 8 LEU A 228
VAL A 268
LEU A 241
LEU A 140
 None
 0.96A 4l1xA-2gszA:
undetectable		 4l1xA-2gszA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		4 / 8 LEU A  32
LEU A  13
THR A  60
LEU A  63
 None
 0.75A 4z90F-2gszA:
undetectable
4z90G-2gszA:
undetectable
4z90H-2gszA:
undetectable
4z90I-2gszA:
undetectable
4z90J-2gszA:
undetectable		 4z90F-2gszA:
21.15
4z90G-2gszA:
21.15
4z90H-2gszA:
21.15
4z90I-2gszA:
21.15
4z90J-2gszA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA510_1
(PROTON-GATED ION
CHANNEL)		 2gsz TWITCHING MOTILITY
PROTEIN PILT
(Aquifex
aeolicus) 		5 / 9 ALA A 246
ILE A 247
ILE A 306
PRO A 298
LEU A 311
 None
 1.07A 5mvmA-2gszA:
undetectable
5mvmE-2gszA:
undetectable		 5mvmA-2gszA:
14.63
5mvmE-2gszA:
14.63