SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gt1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DMA_B_NCAB700_0
(EXOTOXIN A)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		4 / 6 HIS A 266
GLY A  12
TYR A 290
ALA A 270
 None
 0.99A 1dmaB-2gt1A:
undetectable		 1dmaB-2gt1A:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DVT_A_FLPA125_1
(TRANSTHYRETIN)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		5 / 8 LEU A 264
ALA A 186
LEU A 184
LEU A 205
LEU A 202
 None
 1.34A 1dvtA-2gt1A:
undetectable
1dvtB-2gt1A:
undetectable		 1dvtA-2gt1A:
17.08
1dvtB-2gt1A:
17.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA8_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		3 / 3 ASP A 176
LYS A 255
ARG A 273
 None
 0.95A 1ra8A-2gt1A:
1.9		 1ra8A-2gt1A:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XIU_B_9CRB202_1
(RXR-LIKE PROTEIN)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		5 / 12 ILE A   5
ALA A  93
LEU A 147
VAL A  51
HIS A  48
 None
 1.06A 1xiuB-2gt1A:
undetectable		 1xiuB-2gt1A:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DQY_B_CHDB2_0
(LIVER
CARBOXYLESTERASE 1)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		3 / 3 TRP A 116
LYS A 136
PRO A 122
 None
 1.45A 2dqyB-2gt1A:
1.7		 2dqyB-2gt1A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_A_GBNA2414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		4 / 8 GLY A  12
THR A 268
ALA A 269
ALA A 270
 None
 0.53A 2ej3A-2gt1A:
undetectable		 2ej3A-2gt1A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_C_GBNC1414_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		4 / 8 GLY A  12
THR A 268
ALA A 269
ALA A 270
 None
 0.56A 2ej3C-2gt1A:
undetectable		 2ej3C-2gt1A:
25.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		5 / 11 HIS A 198
PRO A 195
TRP A 194
VAL A 278
GLY A 288
 None
 1.00A 2h9tH-2gt1A:
undetectable		 2h9tH-2gt1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H9T_H_SVRH301_1
(THROMBIN)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		5 / 11 HIS A 198
PRO A 195
TRP A 194
VAL A 278
GLY A 289
 None
 0.83A 2h9tH-2gt1A:
undetectable		 2h9tH-2gt1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2M9Q_B_BEZB251_0
(SERINE PROTEASE
INHIBITOR
SERINE PROTEASE
SUBUNIT NS2B, SERINE
PROTEASE NS3)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		5 / 9 ILE A   5
ILE A  91
THR A 144
ALA A  24
LEU A  21
 None
 1.18A 2m9qA-2gt1A:
undetectable		 2m9qA-2gt1A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		5 / 11 HIS A 198
PRO A 195
TRP A 194
VAL A 278
GLY A 288
 None
 1.03A 3bf6H-2gt1A:
undetectable		 3bf6H-2gt1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BF6_H_SVRH301_1
(THROMBIN, HEAVY
CHAIN)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		5 / 11 HIS A 198
PRO A 195
TRP A 194
VAL A 278
GLY A 289
 None
 0.91A 3bf6H-2gt1A:
undetectable		 3bf6H-2gt1A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_D_ROCD201_2
(HIV-1 PROTEASE)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		4 / 4 GLY A 288
ASP A 283
GLY A 280
THR A 188
 None
 0.93A 3k4vC-2gt1A:
undetectable		 3k4vC-2gt1A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		5 / 12 ILE A  31
ALA A  27
VAL A 141
ASP A  23
PHE A 148
 None
 1.28A 3vw1D-2gt1A:
undetectable		 3vw1D-2gt1A:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		4 / 8 ILE A 165
LEU A 271
VAL A 247
GLY A 246
 None
 0.90A 3w1wA-2gt1A:
3.5		 3w1wA-2gt1A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		5 / 11 SER A 265
LEU A 267
THR A 268
HIS A  16
VAL A  14
 None
 1.07A 4e0fA-2gt1A:
undetectable		 4e0fA-2gt1A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_B_LOCB502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		5 / 12 LEU A 264
LEU A 271
ALA A 248
LEU A 244
ALA A 270
 None
 1.23A 4x1kA-2gt1A:
undetectable
4x1kB-2gt1A:
3.8		 4x1kA-2gt1A:
21.85
4x1kB-2gt1A:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BTX_A_EDTA503_0
(SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER))		 2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1
(Escherichia
coli) 		4 / 7 SER A 259
SER A 265
HIS A 266
GLY A 263
 None
 1.05A 6btxA-2gt1A:
undetectable		 6btxA-2gt1A:
23.19