SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gti'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		3 / 3 LEU A   2
VAL A   5
LEU A   9
 None
 0.37A 1mz9B-2gtiA:
undetectable		 1mz9B-2gtiA:
8.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		5 / 9 PHE A 260
VAL A 264
LEU A 278
MET A 237
SER A 235
 None
None
None
None
SO4  A 506 (-4.5A)
 1.00A 1wrkA-2gtiA:
undetectable
1wrkB-2gtiA:
undetectable		 1wrkA-2gtiA:
13.76
1wrkB-2gtiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRK_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		5 / 9 PHE A 260
VAL A 264
PHE A 249
MET A 237
SER A 235
 None
None
None
None
SO4  A 506 (-4.5A)
 1.09A 1wrkA-2gtiA:
undetectable
1wrkB-2gtiA:
undetectable		 1wrkA-2gtiA:
13.76
1wrkB-2gtiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 7 PHE A 260
LEU A 278
MET A 237
SER A 235
 None
None
None
SO4  A 506 (-4.5A)
 1.03A 1wrlA-2gtiA:
undetectable
1wrlB-2gtiA:
undetectable		 1wrlA-2gtiA:
13.76
1wrlB-2gtiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_A_TFPA204_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 7 PHE A 260
PHE A 249
MET A 237
SER A 235
 None
None
None
SO4  A 506 (-4.5A)
 0.78A 1wrlA-2gtiA:
undetectable
1wrlB-2gtiA:
undetectable		 1wrlA-2gtiA:
13.76
1wrlB-2gtiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		5 / 6 PHE A 260
VAL A 264
LEU A 278
MET A 237
SER A 235
 None
None
None
None
SO4  A 506 (-4.5A)
 0.91A 1wrlB-2gtiA:
undetectable		 1wrlB-2gtiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_B_TFPB203_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		5 / 6 PHE A 260
VAL A 264
PHE A 249
MET A 237
SER A 235
 None
None
None
None
SO4  A 506 (-4.5A)
 0.99A 1wrlB-2gtiA:
undetectable		 1wrlB-2gtiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 7 PHE A 260
PHE A 249
MET A 237
SER A 235
 None
None
None
SO4  A 506 (-4.5A)
 0.86A 1wrlE-2gtiA:
undetectable		 1wrlE-2gtiA:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OPX_A_DXCA1002_0
(ALDEHYDE
DEHYDROGENASE A)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		3 / 3 GLY A 119
ARG A 120
TYR A 136
 None
 0.81A 2opxA-2gtiA:
undetectable		 2opxA-2gtiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_C_VIBC223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 8 LEU A  85
LEU A 116
CYH A  80
SER A  82
 None
 0.89A 3lm8A-2gtiA:
undetectable
3lm8C-2gtiA:
undetectable		 3lm8A-2gtiA:
19.95
3lm8C-2gtiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LM8_D_VIBD223_1
(THIAMINE
PYROPHOSPHOKINASE)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 8 LEU A  85
LEU A 116
CYH A  80
SER A  82
 None
 0.94A 3lm8B-2gtiA:
undetectable
3lm8D-2gtiA:
undetectable		 3lm8B-2gtiA:
19.95
3lm8D-2gtiA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		5 / 9 ILE A 142
LEU A 125
ILE A 137
PHE A 128
LYS A 177
 None
SO4  A 503 (-4.0A)
None
None
None
 1.46A 3sj4X-2gtiA:
undetectable		 3sj4X-2gtiA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DAJ_B_0HKB2000_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR M3,
LYSOZYME)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		3 / 3 ASN A  45
LEU A   2
PHE A  58
 None
None
GOL  A 601 ( 4.3A)
 0.76A 4dajB-2gtiA:
undetectable		 4dajB-2gtiA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 7 ASP A 351
SER A 302
SER A 225
ARG A 153
 None
None
None
SO4  A 502 (-2.7A)
 1.21A 4lv9A-2gtiA:
undetectable
4lv9B-2gtiA:
undetectable		 4lv9A-2gtiA:
22.32
4lv9B-2gtiA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_A_ADNA2414_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 6 GLU A 261
PHE A 260
ARG A 284
PHE A 249
 None
 1.49A 4uciA-2gtiA:
undetectable		 4uciA-2gtiA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UCI_B_ADNB2415_1
(RNA-DIRECTED RNA
POLYMERASE L)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 7 GLU A 261
PHE A 260
ARG A 284
PHE A 249
 None
 1.48A 4uciB-2gtiA:
undetectable		 4uciB-2gtiA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 9 GLU A 295
LEU A 282
LEU A 279
ILE A 323
 None
 0.94A 4xtaA-2gtiA:
undetectable		 4xtaA-2gtiA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DSG_A_0HKA1201_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M4,ENDOLYSIN,ENDOLYS
IN,MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		3 / 3 ASN A  45
LEU A   2
PHE A  58
 None
None
GOL  A 601 ( 4.3A)
 0.79A 5dsgA-2gtiA:
undetectable		 5dsgA-2gtiA:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		3 / 3 LYS A 353
ASN A  74
SER A 302
 None
 1.24A 5yw0A-2gtiA:
undetectable		 5yw0A-2gtiA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_A_RFPA502_2
(RIFAMPIN
MONOOXYGENASE)		 2gti REPLICASE
POLYPROTEIN 1AB
(Murine
coronavirus) 		4 / 4 GLN A 224
VAL A 350
ARG A 284
ARG A 226
 SO4  A 502 ( 4.2A)
None
None
None
 1.45A 6brdA-2gtiA:
undetectable		 6brdA-2gtiA:
14.38