SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gtl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OE2_A_CUA502_0
(DISSIMILATORY
COPPER-CONTAINING
NITRITE REDUCTASE)		 2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L3
SUBUNIT
(Lumbricus
terrestris) 		3 / 3 GLU O 130
HIS O 145
HIS O 147
 None
 0.32A 1oe2A-2gtlO:
undetectable		 1oe2A-2gtlO:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_D_MIXD3539_2
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L2
SUBUNIT
(Lumbricus
terrestris) 		3 / 3 VAL N 223
VAL N 110
ASP N 101
 None
 0.78A 2fumD-2gtlN:
undetectable		 2fumD-2gtlN:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLJ_A_SPMA1303_1
(POTASSIUM CHANNEL)		 2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L2
SUBUNIT
EXTRACELLULAR
HEMOGLOBIN LINKER L3
SUBUNIT
(Lumbricus
terrestris) 		3 / 3 ARG O  38
ARG O  43
PRO N  43
 None
 0.85A 2wljA-2gtlO:
undetectable		 2wljA-2gtlO:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_B_CHDB924_0
(FERROCHELATASE,
MITOCHONDRIAL)		 2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L3
SUBUNIT
(Lumbricus
terrestris) 		4 / 7 LEU O 176
ARG O 199
GLY O 110
MET O 125
 None
 1.09A 3hcrB-2gtlO:
undetectable		 3hcrB-2gtlO:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NY4_A_SMXA309_1
(BETA-LACTAMASE)		 2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L3
SUBUNIT
HEMOGLOBIN LINKER
CHAIN L1
(Lumbricus
terrestris) 		4 / 5 ILE O 217
ARG O  53
GLU M  68
GLU M  58
 None
 1.31A 3ny4A-2gtlO:
undetectable		 3ny4A-2gtlO:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 2gtl HEMOGLOBIN LINKER
CHAIN L1
(Lumbricus
terrestris) 		4 / 7 ASP M 205
GLY M 113
THR M 112
PHE M 196
 None
 0.94A 4acaC-2gtlM:
undetectable		 4acaC-2gtlM:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L2
SUBUNIT
(Lumbricus
terrestris) 		3 / 3 PHE N 174
ASP N  79
ARG N 144
 None
 0.82A 4eahF-2gtlN:
undetectable		 4eahF-2gtlN:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L2
SUBUNIT
(Lumbricus
terrestris) 		3 / 3 PHE N 174
ASP N  79
ARG N 144
 None
 0.82A 4eahG-2gtlN:
undetectable		 4eahG-2gtlN:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IKL_A_SUZA201_1
(TRANSTHYRETIN)		 2gtl HEMOGLOBIN LINKER
CHAIN L1
(Lumbricus
terrestris) 		4 / 7 ALA M 149
LEU M 151
THR M 131
SER M 110
 None
 1.12A 4iklA-2gtlM:
undetectable
4iklB-2gtlM:
undetectable		 4iklA-2gtlM:
16.67
4iklB-2gtlM:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_2_BEZ2801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2gtl HEMOGLOBIN LINKER
CHAIN L1
EXTRACELLULAR
HEMOGLOBIN LINKER L3
SUBUNIT
(Lumbricus
terrestris;
Lumbricus
terrestris) 		4 / 4 LEU M  28
ARG O  20
ILE O  24
ILE M  21
 None
 1.17A 5dzk2-2gtlM:
undetectable
5dzkM-2gtlM:
undetectable
5dzkN-2gtlM:
undetectable		 5dzk2-2gtlM:
2.74
5dzkM-2gtlM:
21.61
5dzkN-2gtlM:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 2gtl HEMOGLOBIN LINKER
CHAIN L1
EXTRACELLULAR
HEMOGLOBIN LINKER L3
SUBUNIT
(Lumbricus
terrestris;
Lumbricus
terrestris) 		4 / 4 ILE O  24
ILE M  21
ARG O  20
LEU M  28
 None
 1.12A 5dzkh-2gtlO:
undetectable
5dzkn-2gtlO:
undetectable
5dzkv-2gtlO:
undetectable		 5dzkh-2gtlO:
22.88
5dzkn-2gtlO:
22.88
5dzkv-2gtlO:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 2gtl HEMOGLOBIN LINKER
CHAIN L1
(Lumbricus
terrestris) 		3 / 3 GLY M 113
LEU M 114
HIS M 127
 None
 0.67A 5u63A-2gtlM:
undetectable		 5u63A-2gtlM:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA406_0
(THIOREDOXIN
REDUCTASE)		 2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L2
SUBUNIT
(Lumbricus
terrestris) 		3 / 3 HIS N  45
SER N  48
ARG N 199
 None
 0.99A 5u63A-2gtlN:
undetectable		 5u63A-2gtlN:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_B_ACTB405_0
(THIOREDOXIN
REDUCTASE)		 2gtl HEMOGLOBIN LINKER
CHAIN L1
(Lumbricus
terrestris) 		3 / 3 GLY M 113
LEU M 114
HIS M 127
 None
 0.65A 5u63B-2gtlM:
undetectable		 5u63B-2gtlM:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2gtl HEMOGLOBIN LINKER
CHAIN L1
(Lumbricus
terrestris) 		3 / 3 PHE M 196
ASP M 205
LEU M  50
 None
 0.79A 5uhbC-2gtlM:
2.3		 5uhbC-2gtlM:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2gtl HEMOGLOBIN LINKER
CHAIN L1
(Lumbricus
terrestris) 		4 / 4 ARG M 176
PHE M 196
ASP M 205
LEU M  50
 None
 0.90A 5uhdC-2gtlM:
2.2		 5uhdC-2gtlM:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0V_A_8QSA615_1
(SERUM ALBUMIN)		 2gtl EXTRACELLULAR
HEMOGLOBIN LINKER L2
SUBUNIT
(Lumbricus
terrestris) 		4 / 8 LEU N 182
VAL N 193
LEU N 147
ILE N 130
 None
 0.76A 5v0vA-2gtlN:
undetectable		 5v0vA-2gtlN:
17.13