SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gtp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_A_SAMA226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gtp REGULATOR OF
G-PROTEIN SIGNALING
1
(Homo
sapiens) 		5 / 12 GLY C  82
GLY C  87
ALA C  78
LEU C 103
ILE C  99
 None
 0.95A 3ku1A-2gtpC:
undetectable		 3ku1A-2gtpC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_C_SAMC226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gtp REGULATOR OF
G-PROTEIN SIGNALING
1
(Homo
sapiens) 		5 / 12 GLY C  82
GLY C  87
ALA C  78
LEU C 103
ILE C  99
 None
 0.93A 3ku1C-2gtpC:
undetectable		 3ku1C-2gtpC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_H_SAMH226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gtp REGULATOR OF
G-PROTEIN SIGNALING
1
(Homo
sapiens) 		5 / 12 GLY C  82
GLY C  87
ALA C  78
LEU C 103
ILE C  99
 None
 0.96A 3ku1H-2gtpC:
undetectable		 3ku1H-2gtpC:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2gtp REGULATOR OF
G-PROTEIN SIGNALING
1
(Homo
sapiens) 		4 / 7 PHE C 177
ILE C 182
GLY C  82
LEU C  61
 None
 0.86A 4zdzA-2gtpC:
undetectable		 4zdzA-2gtpC:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2gtp REGULATOR OF
G-PROTEIN SIGNALING
1
(Homo
sapiens) 		5 / 9 PHE C 177
ILE C 182
GLY C  82
LEU C  61
LEU C 190
 None
 1.18A 4ze0A-2gtpC:
undetectable		 4ze0A-2gtpC:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2gtp REGULATOR OF
G-PROTEIN SIGNALING
1
(Homo
sapiens) 		4 / 8 PHE C 177
ILE C 182
GLY C  82
LEU C  61
 None
 0.87A 5eseA-2gtpC:
1.3		 5eseA-2gtpC:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 2gtp REGULATOR OF
G-PROTEIN SIGNALING
1
(Homo
sapiens) 		4 / 8 PHE C 177
ILE C 182
GLY C  82
LEU C  61
 None
 0.82A 5esfA-2gtpC:
undetectable		 5esfA-2gtpC:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EQP_A_BUWA601_1
(CHOLINESTERASE)		 2gtp REGULATOR OF
G-PROTEIN SIGNALING
1
(Homo
sapiens) 		4 / 8 GLY C  82
GLN C  83
PHE C 177
TYR C 174
 None
 0.80A 6eqpA-2gtpC:
undetectable		 6eqpA-2gtpC:
19.40