SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gtr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHF_B_FOLB187_0
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
GLN A  39
ILE A 104
LEU A  42
THR A  22
 None
 1.01A 1dhfB-2gtrA:
undetectable		 1dhfB-2gtrA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 11 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 1.02A 1dhiB-2gtrA:
undetectable		 1dhiB-2gtrA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 1.03A 1draB-2gtrA:
undetectable		 1draB-2gtrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 0.99A 1ra2A-2gtrA:
undetectable		 1ra2A-2gtrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 1.06A 1ra3A-2gtrA:
undetectable		 1ra3A-2gtrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 0.96A 1rb2A-2gtrA:
undetectable		 1rb2A-2gtrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 1.01A 1rb3B-2gtrA:
undetectable		 1rb3B-2gtrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 1.01A 1rd7A-2gtrA:
undetectable		 1rd7A-2gtrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 0.99A 1rd7B-2gtrA:
undetectable		 1rd7B-2gtrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_2
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		3 / 3 ILE A   7
ILE A  18
THR A  22
 None
 0.61A 1rg7A-2gtrA:
undetectable		 1rg7A-2gtrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX2_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 0.96A 1rx2A-2gtrA:
undetectable		 1rx2A-2gtrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X7P_A_SAMA301_0
(RRNA
METHYLTRANSFERASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 11 GLY A 110
MET A 165
LEU A 172
ALA A 174
ALA A 177
 None
 0.86A 1x7pA-2gtrA:
undetectable
1x7pB-2gtrA:
undetectable		 1x7pA-2gtrA:
20.95
1x7pB-2gtrA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 1.06A 2drcB-2gtrA:
undetectable		 2drcB-2gtrA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HNY_A_NVPA999_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A  20
VAL A 108
VAL A  61
GLY A 110
LEU A  55
 None
 1.36A 2hnyA-2gtrA:
undetectable		 2hnyA-2gtrA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 1.02A 3drcB-2gtrA:
undetectable		 3drcB-2gtrA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 10 LEU A  20
VAL A 108
VAL A  61
GLY A 110
LEU A  55
 None
 1.38A 3lp1A-2gtrA:
undetectable		 3lp1A-2gtrA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AN2_A_EUIA1382_2
(DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 1)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		4 / 4 ASN A  31
SER A 118
LEU A 115
THR A  22
 None
 1.46A 4an2A-2gtrA:
undetectable		 4an2A-2gtrA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 1.06A 4dfrB-2gtrA:
undetectable		 4dfrB-2gtrA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTH_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 1.05A 4pthA-2gtrA:
undetectable		 4pthA-2gtrA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 1.01A 4x5gB-2gtrA:
undetectable		 4x5gB-2gtrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ILE A   7
ILE A 104
LEU A  42
ILE A  18
THR A  22
 None
 0.94A 4x5iA-2gtrA:
undetectable		 4x5iA-2gtrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_C_CHDC304_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ARG A 219
LEU A 226
GLN A 228
LEU A 122
 None
 0.96A 5b1aC-2gtrA:
undetectable
5b1aJ-2gtrA:
undetectable		 5b1aC-2gtrA:
20.20
5b1aJ-2gtrA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1A_P_CHDP305_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ARG A 219
LEU A 226
GLN A 228
LEU A 122
 None
 0.93A 5b1aP-2gtrA:
undetectable
5b1aW-2gtrA:
undetectable		 5b1aP-2gtrA:
20.20
5b1aW-2gtrA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ARG A 219
LEU A 226
GLN A 228
LEU A 122
 None
 0.95A 5b3sC-2gtrA:
undetectable
5b3sJ-2gtrA:
undetectable		 5b3sC-2gtrA:
20.20
5b3sJ-2gtrA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B3S_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ARG A 219
LEU A 226
GLN A 228
LEU A 122
 None
 0.97A 5b3sP-2gtrA:
undetectable		 5b3sP-2gtrA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M54_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 12 ALA A 132
THR A 136
ARG A 170
GLY A 181
LEU A 182
 None
 1.23A 5m54E-2gtrA:
undetectable		 5m54E-2gtrA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_B_ADNB401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		4 / 8 LYS A 215
ALA A 216
ASP A 124
ASN A 207
 None
 0.84A 5mvsB-2gtrA:
undetectable		 5mvsB-2gtrA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ARG A 219
LEU A 226
GLN A 228
LEU A 122
 None
 0.92A 5z84C-2gtrA:
undetectable
5z84J-2gtrA:
undetectable		 5z84C-2gtrA:
20.20
5z84J-2gtrA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCQ_P_CHDP306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		4 / 7 ARG A 219
LEU A 226
GLN A 228
LEU A 122
 None
 0.92A 5zcqP-2gtrA:
undetectable
5zcqW-2gtrA:
undetectable		 5zcqP-2gtrA:
20.20
5zcqW-2gtrA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGC_A_D95A816_0
(GEPHYRIN)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		5 / 11 PHE A  71
ILE A  72
LEU A  75
ILE A  90
MET A  35
 None
 1.48A 6fgcA-2gtrA:
2.0		 6fgcA-2gtrA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FOS_A_PQNA2001_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 2gtr CHROMODOMAIN Y-LIKE
PROTEIN
(Homo
sapiens) 		4 / 6 MET A 247
GLY A 242
ALA A  87
LEU A 237
 None
 0.93A 6fosA-2gtrA:
0.0		 6fosA-2gtrA:
14.62