SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '2gtt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1O86_A_LPRA702_2
(ANGIOTENSIN
CONVERTING ENZYME)		 2gtt NUCLEOPROTEIN
(Rabies
lyssavirus) 		4 / 4 SER A 146
VAL A 230
PHE A 203
VAL A  70
 None
A  W  48 ( 4.3A)
None
None
 1.10A 1o86A-2gttA:
undetectable		 1o86A-2gttA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6H_A_CXXA802_1
(TRANSPORTER)		 2gtt NUCLEOPROTEIN
(Rabies
lyssavirus) 		4 / 7 ARG A 270
PHE A 273
ILE A 269
PHE A 242
 None
 1.06A 2q6hA-2gttA:
undetectable		 2q6hA-2gttA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_A_ML1A233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2gtt NUCLEOPROTEIN
(Rabies
lyssavirus) 		4 / 8 ILE A 312
PHE A 260
GLY A 306
MET A 272
 None
 0.98A 2qwxA-2gttA:
undetectable
2qwxB-2gttA:
undetectable		 2qwxA-2gttA:
21.64
2qwxB-2gttA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7H_B_SAMB530_1
(TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN)		 2gtt NUCLEOPROTEIN
(Rabies
lyssavirus) 		3 / 3 TYR A 259
GLU A 255
THR A 354
 None
 1.03A 2y7hB-2gttA:
undetectable		 2y7hB-2gttA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 2gtt NUCLEOPROTEIN
(Rabies
lyssavirus) 		4 / 7 ILE A 249
PHE A 309
PHE A 438
GLY A 346
 None
 1.05A 3em0B-2gttA:
undetectable		 3em0B-2gttA:
15.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_B_SAMB300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 2gtt NUCLEOPROTEIN
(Rabies
lyssavirus) 		3 / 3 TYR A  73
ASP A  69
ASP A  48
 None
 0.76A 3ou7B-2gttA:
undetectable		 3ou7B-2gttA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 2gtt NUCLEOPROTEIN
(Rabies
lyssavirus) 		4 / 8 ILE A 312
PHE A 260
GLY A 306
MET A 272
 None
 0.97A 4qogA-2gttA:
undetectable
4qogB-2gttA:
undetectable		 4qogA-2gttA:
21.64
4qogB-2gttA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2gtt NUCLEOPROTEIN
(Rabies
lyssavirus) 		3 / 3 THR A 252
HIS A 262
LEU A 311
 None
 0.81A 5axdA-2gttA:
undetectable		 5axdA-2gttA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_C_RBVC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 2gtt NUCLEOPROTEIN
(Rabies
lyssavirus) 		3 / 3 THR A 252
HIS A 262
LEU A 311
 None
 0.80A 5axdC-2gttA:
undetectable		 5axdC-2gttA:
24.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHD_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 2gtt NUCLEOPROTEIN
(Rabies
lyssavirus) 		4 / 4 ARG A  98
PHE A 213
ASP A 211
LEU A 143
 None
 1.42A 5uhdC-2gttA:
0.0		 5uhdC-2gttA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 2gtt NUCLEOPROTEIN
(Rabies
lyssavirus) 		3 / 3 TYR A  53
ASN A 119
LEU A  65
 None
 0.76A 6b58A-2gttA:
0.0		 6b58A-2gttA:
23.01